Sanders, D.S.; Patel, D.; Khan, F.B.; Westbrook, R.H.; Webber, C.V.; Ward, A. Milford; Lobo, A.J.; McCloskey, E.V.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA38
Academic Journal
Introduction: Patients with coeliac disease (CD) may have reduced bone mineral density (BMD). The value of case finding for CD in patients presenting with reduced BMD has not been fully assessed. Aim: The aim of this study was to determine the prevalence of CD in patients with reduced BMD, verified by Dual energy x ray absorptiometry (DXA). Methods: All patients attending for a DXA scan (at the Metabolic Bone Unit of the Royal Hallamshire Hospital) were investigated for CD using immunoglobulins, IgG/IgA anti-gliadin antibodies (AGA), and endomys a ant body EMA) Patients were questioned about any possible coeliac associated diseases or gastrointest nal (GI) symptoms (for example anaemia). Any patient with a positive IgA AGA or a positive EMA or only IgG AGA in the presence of IgA deficiency was offered a small bowel biopsy to confirm the diagnosis of CD. Results: 978 patients were recruited from January 01 to December 02. Direct questioning revealed that all patients with unrecognised CD had subtle (Gl) symptoms or a previous history of anaemia. Excluding patients without these symptoms would give a prevalence of 3.9% for osteoporosis (5/127) and 2.6% for osteopaenia (5/191). Conclusion: A case finding approach will allow recognition of undiagnosed adult CD in patients with DXA proven reduced BMD. This may avoid delays n diagnosis of CD a potentially treatable cause of reduced BMD. Initial selection of patients who should be investigated for CD could be based on questioning about Gl symptoms or anaemia.


Related Articles

  • Analysis of the structure and strength of bones in celiac disease patients Ferretti, José; Mazure, Roberto; Tanoue, Patricio; Marino, Alicia; Cointry, Gustavo; Vazquez, Horacio; Niveloni, Sonia; Pedreira, Silvia; Mauriño, Eduardo; Zanchetta, José; Bai, Julio C. // American Journal of Gastroenterology;Feb2003, Vol. 98 Issue 2, p382 

    : ObjectiveThe aim of this study was to gain insight into the pathogenesis of bone mass loss and weakening affecting patients with celiac disease, according to the new concepts of bone structure/strength and muscle/bone interrelationships.: MethodsWe studied serum variables and tomographic...

  • Bone Mineralization in Young Patients with Type 1 Diabetes Mellitus and Screening-identified Evidence of Celiac Disease. Daniel Diniz-Santos; Flávia Brandão; Agnaluce Moreira; Eliézer Vicente // Digestive Diseases & Sciences;May2008, Vol. 53 Issue 5, p1240 

    Abstract  The aims of this study were to evaluate bone mineral density (BMD) and bone turnover markers in patients with type 1 diabetes and screening-identified evidence of celiac disease, i.e., celiac autoimmunity. We screened 50 consecutive type 1 diabetic patients for IgA...

  • Celiac disease transmitted by allogeneic non-T cell-depleted bone marrow transplantation. Bargetzi, M J; Schönenberger, A; Tichelli, A; Fried, R; Cathomas, G; Signer, E; Speck, B; Gratwohl, A // Bone Marrow Transplantation;10/1/97, Vol. 20 Issue 7, p607 

    We observed the occurrence of celiac disease following allogeneic bone marrow transplantation in a patient transplanted for acute leukemia. The marrow donor was his HLA-identical sister, who had suffered from celiac disease since birth. The post-transplant period was characterized by recurrent...

  • Bone mineralisation in ex-preterm infants aged 8 years. Bowden, L. S.; Jones, C. J.; Ryan, S. W. // European Journal of Pediatrics;1999, Vol. 158 Issue 8, p658 

    Abstract In preterm infants, in whom perinatal mineralisation deficits are common, there is little information on long-term bone mineralisation. Using a Hologic QDR 1000 dual energy X-ray absorptiometer, bone mineral content and density (BMC and BMD) were measured in lumbar, spine, forearm and...

  • DECREASED BONE MINERAL DENSITY AT DIAGNOSIS IN PAEDIATRIC INFLAMMATORY BOWEL DISEASE. Croft, N.M.; Ho, J.; Akanle, O.A.; Savage, M.O.; Sanderson, I.R. // Gut;Apr2003 Supplement 1, Vol. 52, pA21 

    Introduction: Significantly reduced bone mineral density (BMD) has been reported in cross sectional studies of children with established inflammatory bowel disease (IBD). In this study we have examined the bone mineral density within 3 months of diagnosis in children with IBD. Methods: Children...

  • Bone Mineral Density, Type 1 Diabetes, and Celiac Disease. Lunt, Helen; Florkowski, Christopher M.; Cook, H. Bramwell; Whitehead, Martin R. // Diabetes Care;Apr2001, Vol. 24 Issue 4, p791 

    Focuses on a study which determined whether celiac disease causes reduced bone mineral density among diabetics. Subject selection; Results; Conclusion.

  • Pre- and Post-Treatment Serum Levels of Cytokines IL-1β, IL-6, and IL-1 Receptor Antagonist in Celiac Disease. Are They Related to the Associated Osteopenia? Fornari, M. Cecilia; Pedreira, Silvia; Niveloni, Sonia; González, Diana; Diez, Roberto A.; Vázquez, Horacio; Mazure, Roberto; Sugai, Emilia; Smecuol, Edgardo; Boerr, Luis; Mauriño, Eduardo; Bai, Julio C. // American Journal of Gastroenterology;Mar1998, Vol. 93 Issue 3, p413 

    Objective: Decreased bone mineral density is a common finding in untreated celiac disease patients. However, the precise pathophysiology of osteopenia remains incompletely understood. Pathological features of gluten sensitivity are associated with local release of proinflammatory and...

  • Bone mineral density in patients undergoing bone marrow transplantation for myeloid malignancies. Bhatia, S.; Ramsay, N.K.C.; Weisdorf, D.; Griffiths, H.; Robison, L.L. // Bone Marrow Transplantation;7/1/98, Vol. 22 Issue 1, p87 

    Bone mineral density (BMD) was measured in 23 patients who had undergone bone marrow transplantation (BMT) at the University of Minnesota for myeloid leukemia. The median age at BMT was 22 years (range 3-53) and the median age at assessment of BMD was 27 years (range 4-56). Total body BMD was...

  • The clinical impact of metabolic bone disease in coeliac disease. Fickling, W. E.; McFarlane, X. A.; Bhalla, A. K.; Robertson, D. A. F. // Postgraduate Medical Journal;Jan2001, Vol. 77 Issue 903, p33 

    Bone mineral density was measured by dual energy x ray absorptiometry (DEXA) at the lumbar spine and femoral neck in 15 adults who had metabolic bone disease in association with coeliac disease (mean age at diagnosis 53.5 years, range 37 to 66). Results were expressed as a T score (the number of...


Read the Article


Sign out of this library

Other Topics