Davies, A.H.G.; Stangou, A.J.; Jervis, N.; Aylwin, S.J.B.; Buxton-Thomas, M.; Ramage, J.K.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA38
Academic Journal
Introduction Neuroendocrine tumours constitute a heterogeneous group of neoplasms, which originate from neuroendocrine cells in the gut, pancreatic s et ce s respiratory epithelium, thyroid, and pituitary glands They are rare tumours, hence series tend to be small from individual centres. These are slow growing turnouts for which many expensive therapies exist. It is important to assess background survival rates to compare to treated groups. Aim: To determine the 3, 5, and 10 year survival in all the patients followed up in the carcinoid clinics at King's College and North Hampshire Hospitals. Method: We carried out a retrospective analysis of the notes and computer database of the carcinoid and neuroendocrine turnout clinics at both hospitals. Results: There were 212 patients on the database. 49 were excluded due to incomplete data. 163 were analysed with an average age of 54.61 years. There were 79 (48.5%) male and 84 (51.5%) female. There were 19 (11.7%) pancreatic islet cell neuroendocrine tumours, 7 (4.3%) fore gut, 66 (40.5%) midgut, 3 (1.8%) hindgut, 9 (5.5%) lung, 52 (31.9%) unknown primary, and 7 (4.35) from various other sites. The peak age of diagnosis was 50-59 years. The 1, 3, 5, and 10 year survival were 97.97%, 82.5%, 64.5%, and 33.72%, respectively. The mean survival was 5.46 years. The 5 year survival for lung tumours was 100% and for midgut 84%. The worst prognosis was for tumours of unknown origin with 45%, 5 year survival. Conclusion: Neuroendocrine tumours have a good overall prognosis compared to other gastrointestinal malignancies. Those with lung and midgut primaries showed the best prognosis, whereas those with an undiagnosed primary the worst. Trials of new therapies are rarely randomised but survival data need to be compared with these figures to demonstrate efficacy.


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