UP-REGULATION OF TOLL-LIKE RECEPTOR EXPRESSION IN CHRONIC HEPATITIS C: CORRELATION WITH CIRCULATING PRO-INFLAMMATORY CYTOKINE LEVELS AND HEPATIC NECRO-INFLAMMATORY ACTIVITY
- Tumor Necrosis Factor-a at the Intersection of Mycobacterial Immunity and Pathogenesis: An Important New Address in Medicine. Iseman, Michael D.; Fischer, Aryeh // Clinical Infectious Diseases;6/1/2008, Vol. 46 Issue 11, p1741
The authors reflect on the significance of tumor necrosis factor (TNF)-Î± on the intersection between nycobacterial immunity and pathogenesis. They consider it as a vital component in host defense against intracellular pathogens. The authors note that its inhibition operates three therapeutic...
- TLR4: the receptor bridging Acanthamoeba challenge and intracellular inflammatory responses in human corneal cell lines. Meiyu Ren; Li Gao; Xinyi Wu // Immunology & Cell Biology;Jul2010, Vol. 88 Issue 5, p529
Acanthamoeba keratitis (AK) is a painful, vision-threatening infection caused by pathogenic strains of the protozoan, Acanthamoeba. Toll-like receptors (TLRs), which are important components of innate immunity, have an important role in the detection of foreign pathogens and the signaling...
- TNF, Cell Death and Inflammation. Bixby, Jacqueline; Ray, Tathagat Dutta; Chan, Francis Ka-Ming // Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy A;Dec2005, Vol. 4 Issue 6, p557
Tumor necrosis factor (TNFa) is a pleiotropic cytokine that mediates diverse biological responses. In the immune system, TNFa facilitates many aspects of immune responses against pathogenic challenges. While TNFa plays a critical role in the immune defense against pathogens, hyper-activation of...
- Fc Gamma Receptor CD64 Modulates the Inhibitory Activity of Infliximab. Wojtal, Kacper A.; Rogler, Gerhard; Scharl, Michael; Biedermann, Luc; Frei, Pascal; Fried, Michael; Weber, Achim; Eloranta, Jyrki J.; Kullak.-Ublick, Gerd A.; Vavricka, Stephan R.; Proost, Paul // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1
Background: Tumor necrosis factor (TNF) is an important cytokine in the pathogenesis of inflammatory bowel disease (IBD). Anti-TNF antibodies have been successfully implemented in IBD therapy, however their efficacies differ among IBD patients. Here we investigate the influence of CD64 Fc...
- TNF. // Encyclopedic Reference of Molecular Pharmacology;2004, p911
An encyclopedia entry for "TNS" is presented, which refers to tumor necrosis factor.
- Cytokine anniversary: TNF trailblazers five centuries apart. Libert, Claude // Nature;7/9/2015, Vol. 523 Issue 7559, p158
A letter to the editor is presented concerning the 40th anniversary of a scientific paper that described the discovery of the cell-signalling protein known as tumour necrosis factor (TNF) in the inflammatory disease a cytokine.
- Inhibitors of MyD88-Dependent Proinflammatory Cytokine Production Identified Utilizing a Novel RNA Interference Screening Approach. Cho, John S.; Kim, Yun C.; Morrison, Sherie L. // PLoS ONE;2009, Vol. 4 Issue 9, p1
Background: The events required to initiate host defenses against invading pathogens involve complex signaling cascades comprised of numerous adaptor molecules, kinases, and transcriptional elements, ultimately leading to the production of proinflammatory cytokines, such as tumor necrosis factor...
- cytokine storm. // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p571
A definition of the term "cytokine storm" is presented, which refers to the massive release of interleukins, tumor necrosis factor alpha and other mediators of inflammation that also trigger bleeding, clotting or shock.
- Suppressed Alloantigen Presentation, Increased TNF-Î±, IL-1, IL-1Ra, IL-10, and Modulation of TNF-R in UV-Irradiated Human Skin. Barr, Robert M.; Walker, Susan L.; Tsang, Wailin; Harrison, Graham I.; Ettehadi, Parisa; Greaves, Malcolm W.; Young, Antony R. // Journal of Investigative Dermatology;May99, Vol. 112 Issue 5, p692
Cytokines induced in skin by ultraviolet radiation cause local and systemic immunosuppression. Tumor necrosis factor Î±, interleukin-1, and interleukin-10 are key mediators in the mouse, but less is known about cytokine synthesis and function in ultraviolet-irradiated human skin. We exposed...