TITLE

IDENTIFICATION OF RISK FACTORS FOR THE DEVELOPMENT OF OESOPHAGO-GASTRIC CANCERS IN SCOTLAND

AUTHOR(S)
Fernandes, E.; Li, A.G.K.; Rashid, H.; Park, K.G.M.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA35
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The early detection and treatment of oesophageal and gastric cancer offers the only chance of an improved outcome. However, the relatively Iow incidence of these tumours renders screening programmes uneconomical and unpractical. Aim: To target groups of patient who are at increased risk of developing gastric and oesophageal cancer and identify risks factor for this disease. Methods: Data from the Scottish Audit of Gastric and Oesophageal Cancer (SAGOC) were prospectively collected form 3293 patients with oesophageal and gastric cancer from 1997 to 1999. Χ² analysis was performed between the risk factors for each tumour type. Results: The population study included cancers of the oesophagus (45%), gastro-oesophageal junction (16%), and stomach (39%). Of the oesophageal tumours, 51% were oesophageal andenocarcinomas (OAC) and 39% squameous cell carcinomas (SCC). Significantly high rates of tobacco and alcohol consumption were seen in patients with SCCs. 14% of patients with OAC had pre-existing Barrett's oesophagus, which was present in 4.3% of the tumours of the OG junction, 0.9% of SCCs and 0.9% of gastric tumours. A history of GOR was present in 16% of the total study group. Conversely, 27% of patients with OAC had history of GOR compared with 20% of junctional tumours, 13% of SCCs, and 12% of gastric cancers. Conclusion: These data indicate the relative importance of known risk factors in the development of upper gastrointestinal cancers in Scotland. While each of these may be proportionally common within the general population, a targeted screening algorithm based upon a combination of such factors could be developed to direct investigation of patients.
ACCESSION #
9747493

 

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