Fernandes, E.; Li, A.G.K.; Rashid, H.; Park, K.G.M.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA35
Academic Journal
Background: The early detection and treatment of oesophageal and gastric cancer offers the only chance of an improved outcome. However, the relatively Iow incidence of these tumours renders screening programmes uneconomical and unpractical. Aim: To target groups of patient who are at increased risk of developing gastric and oesophageal cancer and identify risks factor for this disease. Methods: Data from the Scottish Audit of Gastric and Oesophageal Cancer (SAGOC) were prospectively collected form 3293 patients with oesophageal and gastric cancer from 1997 to 1999. Χ² analysis was performed between the risk factors for each tumour type. Results: The population study included cancers of the oesophagus (45%), gastro-oesophageal junction (16%), and stomach (39%). Of the oesophageal tumours, 51% were oesophageal andenocarcinomas (OAC) and 39% squameous cell carcinomas (SCC). Significantly high rates of tobacco and alcohol consumption were seen in patients with SCCs. 14% of patients with OAC had pre-existing Barrett's oesophagus, which was present in 4.3% of the tumours of the OG junction, 0.9% of SCCs and 0.9% of gastric tumours. A history of GOR was present in 16% of the total study group. Conversely, 27% of patients with OAC had history of GOR compared with 20% of junctional tumours, 13% of SCCs, and 12% of gastric cancers. Conclusion: These data indicate the relative importance of known risk factors in the development of upper gastrointestinal cancers in Scotland. While each of these may be proportionally common within the general population, a targeted screening algorithm based upon a combination of such factors could be developed to direct investigation of patients.


Related Articles

  • Massive Endoscopic Screening for Esophageal and Gastric Cancers in a High-Risk Area of China. Zheng, Xianzhi; Mao, Xuhua; Xu, Kun; Lü, Lingshuang; Peng, Xianzhen; Wang, Min; Xu, Guisheng; Hua, Zhaolai; Wang, Jianping; Xue, Hengchuan; Wang, Jianming; Lu, Cheng // PLoS ONE;12/23/2015, Vol. 10 Issue 12, p1 

    Objective: This study aims to describe the findings from a massive endoscopic screening program in a high-risk area of China and to evaluate the prognosis of patients diagnosed through endoscopic screening compared with those diagnosed at usual hospital visits because of illness. Methods: In...

  • Should Patients with GERD Be Screened Once at Least for Barrett's Epithelium? PRO: The Need to Screen GERD Patients for Barrett's Esophagus—A Greater Yield than Surveillance. Sampliner, Richard E. // American Journal of Gastroenterology;Dec2004, Vol. 99 Issue 12, p2291 

    Focuses on the debate concerning the need for Barrett's epithelium in patients with gastroesophageal reflux disease. Role of the screening on the identification of the premalignant lesion; Significance of the disease epidemiology in providing information for its risk factors; Importance of...

  • Socioeconomic status and risk of adenocarcinoma of the oesophagus and cancer of the gastric cardia in Scotland. Brewster, D H; Fraser, L A; McKinney, P A; Black, R J // British Journal of Cancer;8/1/2000, Vol. 83 Issue 3, p387 

    The incidence of oesophageal adenocarcinoma and gastric cardia cancer increased strikingly in Scotland between 1977 and 1996. In contrast to other cancers of the oesophagus and stomach, which showed a clear relationship with socioeconomic status, no trend was evident for oesophageal...

  • RISK OF OESOPHAGEAL CANCER IN BARRETT'S OESOPHAGUS AND IN GASTRO-OESOPHAGEAL REFLUX. Solaymani-Dodaran, M.; Coupland, C.; Logan, R.F.A. // Gut;Apr2003 Supplement 1, Vol. 52, pA20 

    Introduction: Barrett's oesophagus is recognised to be a pre-malignant condition and the incidence of oesophogeal adenocarcinoma (OAC) in people with Barrett's is much higher than general population. Nevertheless, it has been suggested that gastro-oesophageal reflux per se is a more important...

  • When can a risk factor be used as a worthwhile screening test? Wald, NJ; Hackshaw, A. K. // BMJ: British Medical Journal (International Edition);12/11/99, Vol. 319 Issue 7224, p1562 

    Presents a study which specified the quantitative relation between risk factors and screening tests. Association of a strong risk factor with a disease before it is likely to be a useful screening test; Methodology of the study; Results and discussion; Conclusions.

  • SURVEY OF CURRENT CLINICAL PRACTICE IN THE DIAGNOSIS, MANAGEMENT AND SURVEILLANCE OF BARRETT'S METAPLASIA: A UK NATIONAL SURVEY. Ishaq, S.; Harper, E.; Brown, J.; Moayyedi, P.; Wicks, T.; Watson, P.; Barr, H.; Attwood, S.; Harrison, R.; Jankowski, J. // Gut;Apr2003 Supplement 1, Vol. 52, pA32 

    Introduction: Barrett's metaplasia (BM) is the precursor lesion for oesophageal adenocarcinoma, a tumour with a rising incidence and a uniformly poor prognosis. In spite of the recognition of this fact and the almost exponential increase in clinical and basic science research, much uncertainty...

  • Delays in the diagnosis of oesophagogastric cancer: A consecutive case series. Martin, Iain G.; Young, Sheila // BMJ: British Medical Journal (International Edition);2/15/97, Vol. 314 Issue 7079, p467 

    Examines the time taken to diagnose esophageal or gastric cancer. Identification of the source of delay; Assessment of the clinical importance of gastric and esophageal cancer; Absence of a relationship between the nature of the first symptoms and delay in diagnosis; Reduction or elimination of...

  • Commentary: Japanese point of view. Sano, Takeshi; Maruyama, Keiichi // BMJ: British Medical Journal (International Edition);2/15/97, Vol. 314 Issue 7079, p470 

    Opinion. Comments on the diagnostic procedures for esophageal or gastric cancer in Japan. Examination of the upper gastrointestinal tract; Referral of patients to hospitals along with endoscopic films and a copy of the pathology results; Problems with the delay from the onset of symptoms to...

  • Commentary: Britain does better than Germany before patients reach hospital. Siewert, J.R.; Fink, U. // BMJ: British Medical Journal (International Edition);2/15/97, Vol. 314 Issue 7079, p471 

    Opinion. Compares the delay in diagnosis of gastric and esophageal cancer in Great Britain and Germany. Problems with the absence of typical symptom; Importance of open access to endoscopy; Need to improve the diagnostic process in Great Britain's hospital.


Read the Article


Sign out of this library

Other Topics