TITLE

SEVERITY OF DYSPLASIA IN COLONIC POLYPS AND NOT LESION SIZE IS DIFFERENTIALLY ASSOCIATED WITH ELEVATED FAECAL CALPROTECTIN—A COMPARATIVE STUDY WITH FAECAL [sub α]1ANTITRYPSIN

AUTHOR(S)
Watts, D.; Campbell, S.; Anderson, N.; Brydon, W.G.; Satsangi, J.; Ghosh, S.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA31
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: Levels of both calprotectin(Cal) and α1 antitrypsin(α1 at) have been shown previously to be elevated in colonic neoplastic disease. There are, however, little data on either their comparative performance as markers of neoplasia or their discriminatory function as markers of dysplastic change within polyps. Aim: To assess the sensitivity of faecal Cai and 0clat levels in patients with severely dysplastic colonic polyps. Method and Results: A prospective study of 137 patients (male:female 69:73,median age 68 years, range 24-86) undergoing colonoscopy was made. 44 patients underwent a normal colonoscopy with a median faecal calprotectin of 4 µg/g (range: 1-367) and α1 at 44 µg/g (2-168). 28 patients had one or more large (> 1 cm) polyps (2 right colon, 21 left colon and 5 multiple polyps) but neither Cal (13 µg/g, 1-397, p = 0.1) nor α1 at (51 µg/g, 9-296, p = 0.6) was significantly raised. 8 patients had one or more estimated small (< 1 cm) polyps at colonoscopy (2 right colon, 5 left colon and 1 both sides of colon); again neither faecal Cai (median 2 µg/g, 1-15 µg/g, p = 0.5) nor eclat levels (44 µg/g, p = 0.39) were significantly higher than the normals. 11 adenocarcinomas (10 left colon, 1 right colon) and 31 adenomas (24 left colon, 5 right colon and 1 both sides) were reported. Significant differences in Cai values were found between adenocarcinoma (44 µg/g, 12-397)and adenoma (3.5 µg/g (1-94 µg/g) p = 0.0002) and metaplasia (n = 16, median 5.5 µg/g (1-45 µg/g) p = 0.0009). α1 at was not significantly higher in carcinomas compared to either severely dysplastic adenomas (71 v 46 µg/g, p = 0.53), or the normal group (71 v45 µg/g, p = 0.38). In the severely dysplastic adenomas [n = 15), significantly higher Cal (8 µg/g, 1-48) was found than in those with only little dysplasia (n = 17, 1 µg/g, 1-94, p < 0.05). α1at...
ACCESSION #
9747468

 

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