TITLE

THE PREVENTION OF COLORECTAL CANCER BY COLONOSCOPIC SURVEILLANCE IN INDIVIDUALS WITH A FAMILY HISTORY OF COLORECTAL CANCER

AUTHOR(S)
Dove-Edwin, I.; Sasieni, P.; Adams, J.; Thomas, H.J.W.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA30
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Surveillance by colonoscopy has been recommended for individuals with a significant family history of colorectal cancer. We report results of 2983 surveillance colonoscopies in 1519 individuals. Methods: Families were classified into four groups: hereditary nonpolyposis colorectal cancer (HNPCC = Amsterdam Criteria positive), and those with 1,2, or 3 affected first-degree relatives. Colonoscopy was offered 5 yearly or 3 yearly if an adenoma was detected. The frequencies of advanced neoplasia high risk adenoma or cancer) were ana ysed by age, extent of family history, and findings on previous colonoscopies. Colorectal cancer incidence and mortality during over 11 000 person-years of follow up were compared to those expected in the absence of surveillance. Results: Advanced neoplasia was most frequent in HNPCC (6.5% on initial colonoscopy). In non-HNPCC it was infrequent (1.2%) under age 45 (even when a relative had developed cancer under age 45 years) and on follow up if advanced neoplasia was absent initially (1.3%). After adjusting for the relative risk based on family history and age, there was a highly significant reduction in colorecta/cancer incidence (92% in non-HNPCC, 58% in HNPCC) and mortality (91% in non-HNPCC, 80% in HNPCC). Conclusions: HNPCC family members require surveillance with short intervals. Those with a lesser family history do not require surveillance under age 45 years, and if advanced neoplasia is absent on initial colonoscopy, surveillance intervals may be lengthened. Colonoscopic surveillance reduces the risk of colorectal cancer in those with a strong family history.
ACCESSION #
9747464

 

Related Articles

  • CT colonography accurate in those at high risk for colorectal cancers.  // Hem/Onc Today;7/10/2009, Vol. 10 Issue 13, p27 

    This article discusses a study which examined the use of computed tomographic (CT) colonography as an alternative to colonoscopy in patients with a history of adenoma and those with a family history of colorectal neoplasm.

  • Closely Screen Relatives of Sporadic Colorectal Cancer Patients.  // Modern Medicine;Oct98, Vol. 66 Issue 10, p12 

    Discusses the abstract of the article `Colonoscopic screening in first-degree relatives of patients with `sporadic' colorectal cancer: A case control study,' by A. Pariente, C. Milan et al, published in the July 1998 issue of the `Gastroenterology' periodical.

  • Study Shows Colonoscopies Can Cut Colon Cancer Deaths. Parker, Cheylin // Washington Informer;3/1/2012, Vol. 47 Issue 20, p18 

    The article focuses on a study which shows that getting a colonoscopy can reduce the risk of dying from colon cancer.

  • Continuing Medical Education Questions: July 2011. DeVault, Kenneth R.; Carey, Emily; Hanouneh, Ibrahim; Kane, Saul; Navaneethan, Udayakumar // American Journal of Gastroenterology;Jul2011, Vol. 106 Issue 7, p1207 

    A quiz concerning colonoscopy of elderly patients with colorectal cancer is presented.

  • Continuing Medical Education Questions: March 2010. DeVault, Kenneth R.; Crespo, Sergio; Panossian, Abraham // American Journal of Gastroenterology;Mar2010, Vol. 105 Issue 3, p674 

    A quiz concerning the article "Predictors of Colorectal Cancer after Negative Colonoscopy: A Population-Based Study" is presented.

  • Case-control study of screening colonoscopy in relatives of patients with colorectal cancer Niv, Yaron; Dickman, Ram; Figer, Arie; Abuksis, Galia; Fraser, Gerald // American Journal of Gastroenterology;Feb2003, Vol. 98 Issue 2, p486 

    : ObjectivesThe efficacy of colonoscopic screening and polypectomy for the prevention of colorectal cancer (CRC) is well accepted but has never been documented in a prospective, controlled study. Screening by sigmoidoscopy has been found to reduce mortality from cancer of the rectum and distal...

  • Video Technology Detects Polyps.  // USA Today Magazine;Oct99, Vol. 128 Issue 2653, p15 

    Focuses on virtual computerized tomography (CT) colonography procedure nicknamed `virtual colonoscopy,' a video technology used to detect colon cancer.

  • Prospective evaluation of fecal calprotectin as a screening biomarker for colorectal neoplasia Limburg, Paul J.; Devens, Mary E.; Harrington, Jonathan J.; Diehl, Nancy N.; Mahoney, Douglas W.; Ahlquist, David A. // American Journal of Gastroenterology;Oct2003, Vol. 98 Issue 10, p2299 

    : ObjectivesStool testing is a well established method of screening for colorectal neoplasia. Emerging data suggest that novel biomarkers may offer performance advantages over fecal occult blood. In this large, prospective study, we assessed fecal calprotectin (a leukocyte-derived protein) as a...

  • A prospective, controlled assessment of factors influencing acceptance of screening colonoscopy Harewood, Gavin C.; Wiersema, Maurits J.; Melton III, L. Joseph // American Journal of Gastroenterology;Dec2002, Vol. 97 Issue 12, p3186 

    OBJECTIVES:Medicare beneficiaries now have access to screening colonoscopy (SC). For colon cancer screening to be fruitful, SC must become more acceptable to a broad segment of this population. However, we currently lack knowledge of which aspects of SC have an impact on patient acceptance. The...

  • Colorectal cancer screening linked to reduced late-stage disease.  // Hem/Onc Today;6/10/2013, Vol. 14 Issue 11, p23 

    The article reports that a nested case-control study done by Dr. Chyke A. Doubeni of the University of Pennsylvania's Perelman School of Medicine that revealed the association of screening colonoscopy or sigmoidoscopy with reduced incidence of certain late-stage colorectal cancers.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics