Morris, C.R.; Harvey, I.M.; Stebbing, W.S.L.; Speakman, C.T.M.; Kennedy, H.J.; Hart, A.R.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA27
Academic Journal
Background: Perforated colonic diverticular disease (PCDD) may result from a combination of high intracolonic pressures, secondary to excessive colonic segmentation, and impairment of the mucosal barrier. Calcium channel blockers and antimuscarinic drugs, which reduce colonic contractility and tone, could potentially protect against perforation. The aim of this study was to test this hypothesis using a case-control design. Methods: All cases of acute PCDD were identified over a 5 year period in two hospitals in Norfolk, UK. Each case was matched for age, sex, and date of admission to two controls groups: (a) patients undergoing cataract surgery and (b) patients with basal cell carcinoma. Data on drug use prior to hospital admission were obtained from medical and nursing records and compared between cases and controls. Results: 120 cases of PCDD were identified and matched to 240 controls in each group. A statistically significant protective association was seen between calcium channel blocker use and PCDD using both control groups (see table). No association was found with antimuscrainic drugs. Conclusions: This study has shown for the first time that a protective association exists between calcium channel blockers and PCDD. Further studies are required to confirm this association but calcium channel blockers may represent a potential preventive therapy in PCDD.


Related Articles

  • Perforated colonic diverticular disease: the importance of NSAIDs, opioids, corticosteroids, and calcium channel blockers. Piekarek, Kristoffer; Israelsson, Leif // International Journal of Colorectal Disease;Dec2008, Vol. 23 Issue 12, p1193 

    Perforated colonic diverticular disease is associated with a high rate of late sequel and mortality. The risk of colonic perforation may relate to intracolonic pressure and mucosal barrier function in the wall of diverticula. The use of substances affecting these parameters may therefore be...

  • Fish oil revisited: Ulcerative colitis.  // HealthFacts;May92, Vol. 17 Issue 156, p1 

    Highlights a study of fish oil that shows a benefit to people with ulcerative colitis. Study conducted by William F. Stenson, MD, of Jewish Hospital, St. Louis, Missouri; Report in the April 15, 1992 issue of `Annals of Internal Medicine'; More.

  • An inexpensive and painless alternative to colonoscopy? E.B. // Medical Update;Aug95, Vol. 19 Issue 2, p1 

    Reports on a painless, noninvasive and less costly procedure for the detection of colon disease being developed by scientists at the United States Department of Agriculture and Johns Hopkins University. Mechanics of conventional colonoscopy; Features of the developed process; Potential...

  • Colitis is not psychosomatic.  // USA Today Magazine;Feb92, Vol. 120 Issue 2561, p14 

    Studies the ulcerative colitis, a chronic and sometimes life-threatening disorder. How the disease was once believed to be psychosomatic; Symptoms; Negative effect of the widespread misconception that colitis has a psychiatric origin.

  • Colonic neoplasia: Men over age 60 are at increased risk. Rex, D.K.; Lehman, G.A. // Geriatrics;Nov93, Vol. 48 Issue 11, p92 

    Reports on a clinical study from Indiana University School of Medicine on the risk factors for colonic tumors in patients without symptoms. Association between increased age and increased risk of neoplasia; Prevalence of adenomas among men; Study published at a 1993 issue of the `American...

  • Right-Sided Diverticulitis---Surgical and Nonsurgical Treatment: Two Case Reports and Review of the Literature. Dunicello, Alex; Fares, Louis G.; Oza, Kulin; Valaulikar, Ganapat; Ernits, Martin // American Surgeon;Aug2002, Vol. 68 Issue 8, p740 

    Right-sided diverticulitis is difficult to distinguish from other sources of right-sided abdominal pain. Diverticula localized to the right colon occur at a rate of 6.6 to 14 per cent. Two types of diverticula have been described in the right colon on the basis of etiologic and pathologic...

  • Colon perforation, bilateral pneumothoraces, pneumopericardium, pneumomediastinum, and... Ho, Hao Chih; Burchell, Sherry // American Surgeon;Sep1996, Vol. 62 Issue 9, p770 

    Presents a case of colonoscopic polypectomy complicated by perforation, pneumoperitoneum, bilateral pneumothoraces, pneumopericardium, pneumomediastinum, and subcutaneous emphysema. Anatomic basis for the various clinical presentations of extraluminal air following colonoscopy; Option of...

  • Intermittent subacute intestinal obstruction due to a... Alponat, A.; Kok, K.Y.Y. // American Surgeon;Nov1996, Vol. 62 Issue 11, p918 

    Discusses a case study conducted on a 57-year-old woman with intermittent subacute intestinal obstruction due to a large lipoma of the colon. Information on lipoma of the colon; Treatment used in this disease.

  • Dietary Risk Factors for the Incidence and Recurrence of Colorectal Adenomatous Polyps. Neugut, Alfred I.; Garbowski, Gail C.; Won Chul Lee; Murray, Todd; Nieves, Jeri W.; Forde, Kenneth A.; Treat, Micahel R.; Waye, Jerome D.; Fenoglio-Preiser, Cecilia // Annals of Internal Medicine;1/15/93, Vol. 118 Issue 2, p91 

    Presents a study that investigated the correlation between dietary factors and the incidence and recurrence of colorectal adenomatous polyps. Background on colorectal adenomatous polyps; Examination of polyp characteristics for recurring cases; Comparison of incidence and recurrence in men and...


Read the Article


Sign out of this library

Other Topics