TITLE

DO CALIUM ANTAGONISTS PROTECT AGAINST PERFORATED COLONIC DIVERTICULAR DISEASE? A CASE-CONTROL STUDY

AUTHOR(S)
Morris, C.R.; Harvey, I.M.; Stebbing, W.S.L.; Speakman, C.T.M.; Kennedy, H.J.; Hart, A.R.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA27
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Perforated colonic diverticular disease (PCDD) may result from a combination of high intracolonic pressures, secondary to excessive colonic segmentation, and impairment of the mucosal barrier. Calcium channel blockers and antimuscarinic drugs, which reduce colonic contractility and tone, could potentially protect against perforation. The aim of this study was to test this hypothesis using a case-control design. Methods: All cases of acute PCDD were identified over a 5 year period in two hospitals in Norfolk, UK. Each case was matched for age, sex, and date of admission to two controls groups: (a) patients undergoing cataract surgery and (b) patients with basal cell carcinoma. Data on drug use prior to hospital admission were obtained from medical and nursing records and compared between cases and controls. Results: 120 cases of PCDD were identified and matched to 240 controls in each group. A statistically significant protective association was seen between calcium channel blocker use and PCDD using both control groups (see table). No association was found with antimuscrainic drugs. Conclusions: This study has shown for the first time that a protective association exists between calcium channel blockers and PCDD. Further studies are required to confirm this association but calcium channel blockers may represent a potential preventive therapy in PCDD.
ACCESSION #
9747440

 

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