TITLE

DECREASED BONE MINERAL DENSITY AT DIAGNOSIS IN PAEDIATRIC INFLAMMATORY BOWEL DISEASE

AUTHOR(S)
Croft, N.M.; Ho, J.; Akanle, O.A.; Savage, M.O.; Sanderson, I.R.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA21
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: Significantly reduced bone mineral density (BMD) has been reported in cross sectional studies of children with established inflammatory bowel disease (IBD). In this study we have examined the bone mineral density within 3 months of diagnosis in children with IBD. Methods: Children with IBD underwent dual-energy x ray absorptiometry (DEXA) of the whole body (BMD WB) and lumbar spine (BMD LS) within 3 months from diagnosis. The data were matched for age, sex, and race and expressed as standard deviation scores (SDS). Bone age was recorded (Tanner-Whitehouse) and the BMD adjusted accordingly. CD and UC/IC group data were compared using the Mann-Whitney U test. Osteopenia is defined as BMD SDS between -1.0 and -2.5, osteoporosis < 2.5. Results: 21 children (8 male and 13 female), median age 12.8 years, have been studied. 14 had Crohn's disease (CD), 6 ulcerative colitis (UC), and 1 indeterminate colitis (lC). Bone age was delayed (> 2 years) in 1 and advanced (> 2 years) in 2 children. Median body mass index Z score was -1.08, significantly lower in CD v UC (-0.97 v 1.0). Height for age Z score was -0.06. BMD was reduced both in the whole body (median SDS -1.08) and lumbar spine (-1.38). There was a trend to these being worse in the CD group (BMD WB: CD -1.35 v UC/IC -0.46, p = 0.2; BMD LS, -1.95 v -1.0, p = 0.5). BMD WB SDS was < -1 in 52% of the 21 subjects (osteopenia in 39% and osteoporosis in 13%), and for BMD LS was 66% (osteopenia 42%, osteoporosis 24%). Using BMD not corrected for bone age for the whole body 25% had a BMD score < -1 (osteopenia 25%, osteoporosis 0%) and lumbar spine 38% (osteopenia 28% and osteoporosis in 10%). There was no significantly increased frequency in these abnormalities in the CD group over the UC group. Conclusions: These data demonstrate reduced bone mineral density at diagnosis in a high proportion of children with IBD. As peak BMD is not reached until early adulthood evidence based strategies to manage Iow BMD...
ACCESSION #
9747397

 

Related Articles

  • OSTEOPOROZA WTÓRNA O CIĘŻKIM PRZEBIEGU U DWOJGA DZIECI Z CHOROBÄ„ LEÅšNIOWSKIEGO-CROHNA. Chlebna-Sokół, Danuta; Jakubowska-Pietkiewicz, Elżbieta; Kiliańska, Agnieszka; Golec, Joanna // Przeglad Pediatryczny;2007, Vol. 37 Issue 4, p408 

    The aim of this study was to present the diagnostic process and treatment of secondary osteoporosis in 2 children with Crohn's disease treated with glycocortycosteroides. The article reviews clinical course of the disease and dual energy X-ray absorptiometry (DXA) results in these cases. It also...

  • Inflammatory bowel disease related osteonecrosis. Klingenstein, Gregory G; Shah, Asit K; Levy, Roger N; Present, Daniel H // American Journal of Gastroenterology;Sep2003 Supplement, Vol. 98, pS254 

    An abstract of the article "Inflammatory Bowel Disease Related Osteonecrosis," by Gregory G. Klingenstein, Asit K. Shah, and Roger N. Levy is presented.

  • Frequency of Bone Marrow Toxicity by Using Pattern of Azathioprine in Inflammatory Bowel Disease Patients. Kyung Hee Hyun; Suck-Ho Lee; Jae Min Shin; Dong Il Park; Chang Kyun Lee; Jeong Eun Shin; Chang Soo Eun; Kyu Chan Huh; Young Hwangbo // Intestinal Research;2012, Vol. 10 Issue 3, p244 

    Background/Aims: The most important adverse effect of azathioprine (AZA) is bone marrow toxicity (BMT). Many physicians have preferred a gradual dose increment (GDI) policy for the prevention of BMT. The aim of this study was to evaluate the efficacy of GDI for the prevention of AZA-induced BMT...

  • Reduced incidence of acute graft versus host disease (GVHD) of the gut in Chinese carriers of Helicobacter Pylori during allogeneic bone marrow transplantation. Au, W. Y.; Wong, R. W. M.; Wong, B. C. Y.; Lie, A. K. W.; Liang, R.; Leung, A. Y. H.; Kwong, Y.-L. // Annals of Hematology;Jan2004, Vol. 83 Issue 1, p34 

    Helicobacter pylori (H. Pylori) infection is associated with gastritis and peptic ulcer, but its relationship with gut graft versus host disease (GVHD) is unknown. We investigated the association between H. Pylori carriage and incidence and severity of mucosal toxicity and GVHD in 128...

  • Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. Koller, Felicitas L; Dozier, E Ashley; Nam, Ki Taek; Swee, Mei; Birkland, Timothy P; Parks, William C; Fingleton, Barbara // Laboratory Investigation (00236837);Dec2012, Vol. 92 Issue 12, p1749 

    Inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) represent serious health burdens because of both the tissue-damaging disease itself and an elevated risk of colon cancer. The increased expression of many members of the matrix metalloproteinase (MMP) family of enzymes that occurs...

  • Use of risedronate to prevent bone loss following a single course of glucocorticoids: findings from a proof-of-concept study in inflammatory bowel disease. Kriel, M. H.; Tobias, J. H.; Creed, T. J.; Lockett, M.; Linehan, J.; Bell, A.; Przemioslo, R.; Smithson, J. E.; Brooklyn, T. N.; Fraser, W. D.; Probert, C. S. J. // Osteoporosis International;Mar2010, Vol. 21 Issue 3, p507 

    We performed a randomised controlled trial (RCT) to determine whether risedronate 35 mg once weekly prevents bone loss following an 8-week reducing course of prednisolone given for an exacerbation of inflammatory bowel disease (IBD). The greatest change in bone mineral density (BMD) was at...

  • Long-Term Development of Bone Geometry and Muscle in Pediatric Inflammatory Bowel Disease. Werkstetter, Katharina J.; Pozza, Susanne Bechtold-Dalla; Filipiak-Pittroff, Birgit; Schatz, Stephanie B.; Prell, Christine; Bufler, Philip; Koletzko, Berthold; Koletzko, Sibylle // American Journal of Gastroenterology;May2011, Vol. 106 Issue 5, p988 

    OBJECTIVES:The muscle-bone unit is crucial for normal bone development. As muscle mass is frequently reduced in pediatric patients with inflammatory bowel disease (pIBD), we investigated the impact of muscles on the bone development over time.METHODS:Bone and muscle parameters were measured...

  • Vitamin D Status and Bone Density in Recently Diagnosed Inflammatory Bowel Disease: The Manitoba IBD Cohort Study. Leslie, William D.; Miller, Norine; Rogala, Linda; Bernstein, Charles N. // American Journal of Gastroenterology;Jun2008, Vol. 103 Issue 6, p1451 

    OBJECTIVES: Bone mineral density (BMD) is usually normal at the time of inflammatory bowel disease (IBD) diagnosis. The purpose of this study was to evaluate the role of vitamin D metabolism in recently diagnosed IBD. METHODS: Adult subjects with recently diagnosed IBD (median 4 yr) were...

  • Altered Bone Metabolism in Inflammatory Bowel Disease. Bischoff, Stephan C.; Herrmann, Annette; Göke, Michael; Manns, Michael P.; Von zur Mühlen, Alexander; Brabant, Georg // American Journal of Gastroenterology;Jul1997, Vol. 92 Issue 7, p1157 

    A reduced bone mineral density has been reported in inflammatory bowel disease (IBD). Objective: To assess the mechanisms of bone disease in IBD. Methods: We studied in 90 patients (61 with Crohn's disease, 22 with ulcerative colitis, 7 with indeterminate colitis) biochemical markers of bone...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics