Solaymani-Dodaran, M.; Coupland, C.; Logan, R.F.A.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA20
Academic Journal
Introduction: Barrett's oesophagus is recognised to be a pre-malignant condition and the incidence of oesophogeal adenocarcinoma (OAC) in people with Barrett's is much higher than general population. Nevertheless, it has been suggested that gastro-oesophageal reflux per se is a more important determinant of risk. The current study was set up to explore the risk of oesophageal cancer (OC) and specifically OAC in Borrett's using a total of 166 228 person-years follow-up experience from General Practice Research Database (GPRD). Methods: The 27 813 study subjects constitute four groups: Barrett's oesophagus group (1677), oesophagitis group (6392), simple reflux group (6328), and normal group (13 416). The last three groups were 4/1, 4/1, and 8/1 matched to the Barrett group according to their GP practice, date of birth, and sex, respectively. All prevalent cases of OC, including those diagnosed before or in the first year after the diagnosis of their condition, were excluded from the analysis. Hazard ratios were calculated using Cox-proportional hazard regression analysis. Using the England and Wales cancer registry data, the incidence of non-AC cancer of oesophagus and subsequently the estimated number of observed AC were worked out in study groups and the relative rate were calculated by standardised incidence ratio method. Results: A total of 137 oesophageal cancer cases were identified in study subjects of which 80 cases were excluded as being prevalent. 57 were entered into the analysis. The results have been presented in the table. Conclusion: Barrett's oesophagus increases oesophageal cancer risk about 20 times and oesophageal adenocarcinoma about 50 times in comparison to general population. There is only a modest increase in risk of oesophageal cancer in patients with reflux but no record of Barrett's. Given that the person-years follow-up in Barrett's group is about twice the largest previous study lower relative risk estimates further emphasises the...


Related Articles

  • BARRETT'S OESOPHAGUS: OESOPHAGEAL ADENOCARCINOMA INCIDENCE AND RISK FACTORS. Campbell, E.; Cooper, B. T.; Riley, S. A.; Trudgill, N. J. // Gut;Apr2004 Supplement 3, Vol. 53, pA27 

    Barrett's oesophagus (BO) is associated with the development of oesophageal adenocarcinoma (OA). However, recent evidence suggests many existing studies have been too small and overestimate the risk of OA. This article presents the largest follow up series of BO in England and examines the...

  • Oesophageal and gastric cancer awareness.  // Gastrointestinal Nursing;May2010, Vol. 8 Issue 4, p6 

    In this article the author discusses the aspects of oesophageal and gastric cancer awareness. She mentions about the awareness campaigns which were aimed to educate and make people aware of signs and symptoms of oesophageal and gastric cancer. She informs that medical personnel also provide...

  • Temozolomide associated with oesophagitis.  // Reactions Weekly;Nov2015, Vol. 1576 Issue 1, p9 

    The article reports on the association of the alkylating agent temozolomide with oesophagitis.

  • Breast implants and offspring health.  // Pediatrics for Parents;1999, Vol. 18 Issue 9, p11 

    Reports on a study conducted by doctors in Denmark, on the risk of esophageal diseases in infants whose mothers had silicone breast implant, published in the November 1998 issue of the `Pediatrics' periodical. Comparison of risk to the infant population as a whole.

  • Symptom severity and oesophageal chemosensitivity to acid in order and young patients with gastro-oesophageal reflux. Fass, Ronnie; Pulliam, Gloria // Age & Ageing;Mar2000, Vol. 29 Issue 2, p125 

    Presents information on a study which compared the extent of esophageal mucosal injury, acid exposure, symptom severity and perception thresholds for acid infusion in older and younger patients with gastro-esophageal reflux. Methods used in the study; Results; Factors contributing to a...

  • Response to Lenglinger. Cooper, Gregory S; Chak, Amitabh // American Journal of Gastroenterology;Oct2009, Vol. 104 Issue 10, p2633 

    A response by Gregory S. Cooper and Amitabh Chak to a letter to the editor about their article "Receipt of previous dangers diagnoses and endoscopy outcome from esophageal adenocarcinoma: a population-based study with temporal trends" in the 2009 issue is presented.

  • Alendronic acid.  // Reactions Weekly;3/5/2011, Issue 1341, p5 

    The article presents the case of an 84-year-old woman who developed Boerhaave's syndrome following treatment with alendronic acid for osteoporosis.

  • Sodium polystyrene sulfonate.  // Reactions Weekly;7/7/2012, Issue 1409, p41 

    The article describes the case of a 53-year-old man with gastroparesis who developed a drug- induced oesophageal ulcer while receiving sodium polystyrene sulfonate for hyperkalaemia.

  • Acenocoumarol/enoxaparin sodium.  // Reactions Weekly;Nov2015, Vol. 1576 Issue 1, p15 

    The article presents a case study of a 31-year-old male patient suffering from downhill oesophageal variceal bleeding after administration of enoxaparin sodium and acenocoumarol.


Read the Article


Sign out of this library

Other Topics