Rutter, M.D.; Wilkinson, K.H.; Schofield, G.; Rumbles, S.; Saunders, B.P.; Forbes, A.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA14
Academic Journal
Background and Aim: The cancer risk in patients with longstanding extensive ulcerative colitis (UC is highly variable. We aimed to study potent al factors that might predict cancer risk in UC. Methods: Case control study of 204 patients on biennial colonoscopic surveillance of extensive UC. 68 cases with dysplasia or CRC and 136 controls without dysplasia/CRC were matched for sex, age at UC onset, disease duration, and extent. Data were obtained from colonoscopy and pathology reports, case notes, and prospective patient survey. Segmental colonoscopic and microscopic inflammation was recorded using a simple score (0, normal; 1, quiescent/ chronic inflammation; 2,3, and 4, mild, moderate, and severe active inflammation). Each surveillance colonoscopy for every patient was scored. The mean value was used for analysis. Results: Univariate analysis is shown in the table. On multivariate analysis, only the microscopy score remained significant (p < 0.001). Conclusion: These data suggest that colonic inflammation is an important risk factor for dysplasia/CRC development. Endoscopic and histological grading at surveillance colonoscopy could allow better risk stratification for surveillance programmes.


Related Articles

  • COLONOSCOPIC APPEARANCES HELP PREDICT DYSPLASIA RISK IN ULCERATIVE COLITIS. Rutter, M.D; Schofield, G.; Wilkinson, K.H.; Forbes, A.; Saunders, B.P. // Gut;Apr2003 Supplement 1, Vol. 52, pA4 

    Background and aim: Colonoscopic surveillance attempts to reduce the excess cancer risk in ulcerative colitis (UC). We aimed to assess whether colonoscopic appearances help to predict cancer risk. Methods: A case control study of patients on UC surveillance; 68 patients with dysplasia/colorectal...

  • COMPLICATION RATES AND PATIENTS' EXPERIENCE OF COLONOSCOPY IN ULCERATIVE COLITIS SURVEILLANCE. Rutter, M.D.; Wilkinson, K.H.; Forbes, A.; Saunders, B.P. // Gut;Apr2003 Supplement 1, Vol. 52, pA110 

    Background and Aim: Colonoscopic surveillance for cancer in ulcerative colitis (UC) may reduce cancer mortality. However, colonoscopy itself is not without risks. We aimed to quantify these risks. Method: Patients with UC on colonoscopic surveillance were sent a questionnaire gathering...

  • PAN-COLONIC INDIGO CARMINE DYE SPRAYING FOR THE DETECTION OF DYSPLASIA IN ULCERATIVE COLITIS. Rutter, M.D.; Schofield, G.; Price, A.B.; Talbot, I.C.; Saunders, B.P. // Gut;Apr2003 Supplement 1, Vol. 52, pA6 

    Background and Aim: Patients with longstanding extensive ulcerative colitis (UC) are at increased risk of colorectal cancer. Colonoscopic surveillance is often performed, and relies heavily on multiple non-targeted mucosal biopsies detecting occult dysplasia. Chromoendoscopy can aid detection of...

  • HOW EFFECTIVE IS CANCER SURVEILLANCE IN ULCERATIVE COLITIS? Rutter, M.D.; Wilkinson, K.H.; Rumbles, S.; Forbes, A.; Saunders, B.P. // Gut;Apr2003 Supplement 1, Vol. 52, pA66 

    Background & Aim: Patients with longstanding extensive ulcerative colitis (UC) are at increased risk of colorectal cancer (CRC). We assessed the value of a long-running colonoscopic surveillance programme. Methods: Patients on biennial colonoscopic surveillance (from 1975 onwards) with...

  • Bowel cancer.  // Good Health (Australia Edition);Dec2010, p96 

    The article offers information on bowel cancer or colon cancer. It states that the chances of bowel cancer starts after the age of 40 years. It mentions that it grows very slowly and its symptoms include rectal bleeding, constipation and anemia. It highlights that people whose close relatives...

  • The Risk for Cancer or Dysplasia in Ulcerative Colitis Patients With Primary Sclerosing Cholangitis. Shetty, Kirti; Rybicki, Lisa; Brzezinski, Aaron; Carey, William D.; Lashner, Bret A. // American Journal of Gastroenterology;Jun1999, Vol. 94 Issue 6, p1643 

    OBJECTIVES: Recent studies have implicated primary sclerosing cholangitis (PSC) as a risk factor for colorectal cancer (CRC) in ulcerative colitis (UC). Our study was designed to define both the risk and the risk factors for CRC or dysplasia in a large UC cohort with PSC. METHODS: Patients with...

  • PREDICTING OUTCOME AND RISK ASSESSMENT IN SEVERE ULCERATIVE COLITIS. Ho, G.T.; Mowat, C.; Goddard, C.J.R.; Fennell, J.M.; Shah, N.B.; Prescott, R.P.; Satsangi, J. // Gut;Apr2003 Supplement 1, Vol. 52, pA69 

    Backgrounds/Aims: The rate of failure of medical therapy in severe ulcerative colitis (UC) remains high (30-40%). We have identified predictor factors associated with poor outcome in patients presenting with severe attacks of UC and devised a numerical scoring system that categorises patients by...

  • A patient with rectal cancer associated with ulcerative colitis in whom endoscopic ultrasonography was useful for diagnosis. Shimizu, Seiji; Myojo, Satoshi; Nagashima, Masako; Okuyama, Yusuke; Sugeta, Nobuyuki; Sakamoto, Shin'ichi; Kutsumi, Hiromu; Otsuka, Hirotomo; Suyama, Yoshikazu; Fujimoto, Sotaro // Journal of Gastroenterology;1999, Vol. 34 Issue 4, p516 

    Abstract: Endoscopic ultrasonography (EUS) was helpful for the diagnosis of rectal cancer associated with ulcerative colitis. The patient was a 38-year-old Japanese man with a 19-year history of relapsing-remitting type ulcerative colitis involving the entire colon. Routine colonoscopy revealed...

  • Delayed Perforation of the Cecum after Diagnostic Biopsy. Loggan, Michael; Moeller, Donald D. // American Journal of Gastroenterology;Dec1984, Vol. 79 Issue 12, p933 

    Colonoscopy is an important diagnostic study in monitoring patients with chronic ulcerative colitis for carcinoma and dysplasia (precancer). A 76-year-old woman with chronic ulcerative colitis of 13 years' duration underwent colonoscopy. Biopsies were obtained at 10-cm intervals throughout the...


Read the Article


Sign out of this library

Other Topics