Dolwani, S.; Hawthorne, A.B.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA12
Academic Journal
Background and Aims: Previous studies in the United Kingdom have either been regional if population based or entirely based on statistics from the Registrar General's office. We aimed to ascertain the non-cancer mortality in persons < 75 years of age ascribed to inflammatory bowel disease via a notification system throughout the UK conducted through all members of the BSG from Jan 2000 to Dec 2001. We then compared this data with that from the Office for National Statistics (ONS). Methods: All deaths in patients with IBD were notified to the BSG central audit office. Further details and death certificate diagnosis were then requested from the notifying clinician. Subgroup analysis was done according to diagnosis, age, sex, cause of death, duration, site, extent, and operative mortality. These data were then compared with that from the ONS in England and Wales, Scotland, and Northern Ireland. Results: One hundred and thirty two patients were recorded as having died due to IBD during this period, of which 108 were < 75 years. Of these, 61 had Crohn's disease, 44 had ulcerative colitis (UC), and 3 had indeterminate colitis. Twenty six patients (24%) died within a year after a diagnosis was made; 36 (33.3% died within 2 years of diagnosis; 7 (6.5%) had death attributed to medical therapy; and 51 (47.2%) had surgery prior to death. The median time to death after surgery was 7 days When analysed according to immediate cause (IA on death cert), 23 patients (21.3%) had septicaemia, 18 patients (16.7%) colonic perforation, 9 patients (8.3%) multi-organ failure, 8 (7.4%) thromboembolic events (PE), and a similar percentage had pneumonia. There were more female deaths (35 v 20) in Crohn's compared to UC. Patients aged < 35 years accounted for 25% of all deaths. During the same period the ONS reported 128 deaths due to UC and 240 to Crohn's disease (which would include cancer related IBD mortality). Conclusions: Younger patients and those within the first year from...


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