TITLE

FATTY ACID COMPOSITION AND FUNCTION OF MONONUCLEAR CELLS IN CROHN'S DISEASE

AUTHOR(S)
Trebble, T.; Stroud, M.A.; Arden, N.K.; Ballinger, A.; Fine, D.R.; Mullee, M.A.; Wootton, S.A.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA11
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Inflammation in Crohn's disease (CD) is mediated by mononuclear cells and is associated with increased production of TNF α and prostaglandin E2 (PGE[sub 2]). In active CD, dietary supplementation with fish oil results in anti-inflammatory effects associated with increases in eicosapentaenoic acid (EPA) and reductions in arachidonic acid (AA) concentrations in plasma. However, in the unsupplemented state the relationship between habitual dietary fat intake, EPA, and AA incorporation into mononuclear cells and TNF α/PGE2 production is uncertain. The fatty acid composition and synthetic function of peripheral blood mononuclear cells (PBMC) were determined in 53 CD patients, stratified into active and inactive disease groups by Crohn's Disease Activity Index, and age and sex-matched healthy controls. There were no differences between CD and controls in dietary fat or total energy intake. Lower concentrations of AA were noted in active CD (20.2%) v controls (24.0%) (p < 0.001) and inactive CD (20.2%) v controls (23.8%) (p < 0.001). Higher concentrations of EPA were noted in active CD (0.7%) and inactive CD (0.8%) vcontrols (0.3% for each control group; p = 0.001). α linolenic acid, the precursor of EPA, was increased in active CD v controls (p = 0.003) but no differences were noted in concentrations of the AA precursor, linoleic acid. Trends towards a reduction in PGE[sub 2] production were noted in inactive CD v controls, but no differences in production of TNF α were seen. CD is associated with alterations in the availability of AA and EPA in both active and inactive states. This cannot be simply explained by altered dietary intake but may be an adaptive or pathological response to the disease process. The anti-inflammatory response to dietary fish oil may reflect a pharmacological effect, and not the correction of a deficiency of EPA. The response of mononuclear cell composition and function to dietary fish oil warrants further investigation.
ACCESSION #
9747326

 

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