Association of Interleukin-1 RN polymorphism and gastric cancer in Taiwan

Hsu, P.; Chen, A.; Yamaoka, Y.; Hwang, I.; Lo, G.; Lai, K.
September 2002
Gut;Sep2002 Supplement 2, Vol. 51, pA10
Academic Journal
Aim: To evaluate the genetic associations of IL-IB and IL-1RN polymorphisms with gastric cancer in Taiwan. Methods: Genomic DNA from 98 unrelated Taiwanese patients with gastric adenocarcinoma and 100 ethically matched healthy controls was typed for polymorphisms at positions -31, -511, and +3954 in the IL-IB gene, and the variable number of tandem repeats polymorphisms in intron 2 of the IL-1RN gene. Results: The allele frequencies of IL-1RN*2 in gastric cancer cases were significantly higher than those in healthy controls (9% vs. 4%, p = 0.024). The allele frequencies of IL-IB -31, IL-1B -511 and IL-1B +3954 did not differ. A significant association was found between IL-1RN*2 carriers and the risk of developing intestinal type gastric carcinoma, with an odds ratio (OR) of 2.8 (95%CI: 1.0-7.6; p = 0.014). A trend towards an increased risk for the development of diffuse type gastric carcinoma in IL-1 RN*2 carriers was also observed (OR= 2.4; 95% CI: 0.8-7.1; p = 0.130). No significant relationship was noted in patients with atypical carcinoma. Additionally, a synergistic interaction between blood type A and IL-1 RN*2 carriers existed (OR= 4.8; 95% CI: 1.0-23.5). Conclusions: Genetic polymorphism of IL-1RN*2 and blood type A is associated with the development of gastric cancer, especially intestinal type gastric cancer in Taiwan.


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