TITLE

PLASMA INTERLEUKIN-18 (IL-18) LEVELS IN CHRONIC ALCOHOLIC LIVER DISEASE (ALD) AND ALCOHOLIC HEPATITIS (AH) ARE RELATED TO DISEASE SEVERITY

AUTHOR(S)
Evans, C.D.J.; Robertson, S.E.; Gracie, J.A.; McInnes, I.B.; Morris, A.J.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim and Background: IL-18 is a novel pro-inflammatory cytokine of the IL-1 family and is critical in the development of Th-1 responses. Th-1 responses have been implicated in the pathogenesis of ALD. We investigated IL-18 expression in patients with ALD and AH. Patients and Methods: We studied inpatients with ALD (n = 48, I/P ALD), outpatients with compensated ALD (n = 13, O/P ALD), and healthy volunteers (n = 15, HVs). The mean age of the I/P ALD (40 males) was 47.7 years and that of the O/P ALD group 55.2 years. Other forms of chronic liver disease were excluded by standard serological tests. IL-18 levels were measured by ELISA (Diaclone). Whole blood cell culture (WBC) +/-lipopolysacchoride (LPS) was performed to assess lL-18 production. A Childs-Pugh score and a Maddrey's Discriminant Function were calculated for all patients. The results were analysed by Mann-Whitney U test. Results: Inpatients consisted of five with Childs grade A, 17 B, and 26 C. Eighteen had a MDF < 24, 9 a MDF of 24-32, and 21 a MDF > 32. Plasma IL-18 levels were significantly elevated in the I/P ALD group when compared with O/P ALD and HVs (all units pg/ml), (174 +/- 170, 45 +/- 52, and 32 +/- 83; p < 0.01 and p < 0.001). IL-18 levels in Child's C inpatients (226 +/- 214) were significantly elevated compared to Child's A inpatients (27 +/- 38; p < 0.01). Higher plasma IL-18 levels were found in inpatients with moderate/ severe AH (MDF > 24) when compared with inpatients with MDF < 24, O/P ALDs, and HVs (224 +/- 203, 93 +/- 89, 45 +/- 83, and 32 +/- 52; p < 0.02, p < 0.002, and p < 0.0001, respectively). Patients with Childs grades B/C showed no incremental rise in lL-18 production following LPS stimulation. A similar result was obtained on analysis of patients with moderate/severe AH (206 +/- 190 to 217 +/- 214). Conclusions: Plasma IL-18 is elevated in patients with ALD. IL-18 levels are higher in patients with increasing severity of ALD (Childs grade B/C) and AH (MDF > 24). In...
ACCESSION #
9747243

 

Related Articles

  • They won't let their son die. Adler, J.; Hager, M. // Newsweek;11/16/1987, Vol. 110 Issue 20, p98 

    Augusto and Michaela Odone's son, Lorenzo, is suffering from a crippling and usually fatal genetic disorder known as ALD, a disease which strikes young boys and is characterized by an unusual accumulation of very long chain saturated fatty-acid molecules, which in an unknown manner destroy the...

  • Peroxisomal Dysfunction in Inflammatory Childhood White Matter Disorders: An Unexpected Contributor to Neuropathology. Singh, Inderjit; Singh, Avtar K.; Contreras, Miguel A. // Journal of Child Neurology;Sep2009, Vol. 24 Issue 9, p1147 

    The peroxisome, an ubiquitous subcellular organelle, plays an important function in cellular metabolism, and its importance for human health is underscored by the identification of fatal disorders caused by genetic abnormalities. Recent findings indicate that peroxisomal dysfunction is not only...

  • Protecting against the lethal effects of chronic inflamation.  // Life Extension;May2003, Vol. 9 Issue 5, p18 

    Discusses the protection against the lethal effects of chronic inflammation. Characteristics of people suffering from chronic disease; Cytokine panel and optimal anti-inflammatory ranges; Importance of cytokine testing for those suffering from chronic illness; Methods of lowering elevated...

  • Cytokines in Dementias. Tarkowski, Elisabeth // Current Drug Targets - Inflammation & Allergy;Jun2002, Vol. 1 Issue 2, p193 

    Knowledge regarding putative inflammatory component(s) participating in Alzheimer's disease (AD) and in vascular dementia (VAD) remains scarce. Recently, we have demonstrated the presence of inflammatory components, such as cytokines, in the CSF of demented patients. Although the initial events...

  • Macrophage Migration Inhibitory Factor and the Discovery of Tautomerase Inhibitors. Orita, Masaya; Yamamoto, Satoshi; Katayama, Naoko; Fujita, Shigeo // Current Pharmaceutical Design;Jun2002, Vol. 8 Issue 14, p1297 

    Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine released from T-cells and macrophages, and is a key molecule in inflammation. Although a detailed understanding of the biological functions of MIF has not yet been found, it is known that MIF catalyzes the...

  • late-phase reaction.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1304 

    An encyclopedia entry for "late-phase reaction" which refers to inflammation of any part of the body brought by the release of cytokines is presented.

  • Effect of cyclosporin A on inflammatory cytokine production by U937 monocyte-like cells. Losa Garcia, Juan E.; Martín de Cabo, María Rosa; Rodríguez, Fernando Mateos; Losada, Jesús Pérez; López, Antonio Jiménez; Arellano, José Luis Pérez // Mediators of Inflammation;Aug2000, Vol. 9 Issue 3/4, p169 

    Cyclosporin A (CsA) is an immunosuppresor drug that has been used in the treatment of several types of inflammatory diseases. In some of them the inhibition of T-lymphocyte activation does not suitably account for the observed beneficial effect, suggesting that CsA could act on other types of...

  • Cytokines and Chemokines in Meningeal Inflammation: Biology and Clinical Implications. Tauber, Martin G.; Moser, Bernhard // Clinical Infectious Diseases;1/1/1999, Vol. 28 Issue 1, p1 

    Studies the biological and clinical implications of cytokines and chemokines in meningeal inflammation. Structure and biology of cytokines and chemokines; Central nervous system infections; Effects of cytokines on the brain; Prognostic impact of cytokines and chemokines.

  • An Immunohistochemical Analysis of Cytokine Expression in Allergic and Irritant Contact Dermatitis: Investigative Report. Ulfgren, Ann-Kristin; Klareskog, Lars; Lindberg, Magnus // Acta Dermato-Venereologica;May2000, Vol. 80 Issue 3, p167 

    The purpose of this study was to investigate whether the specific and non-specific inflammatory responses to allergens and irritants give rise to immuno-histochemical detectable differences in the cytokine profile in the skin. Skin biopsies taken at 0, 6, 24 and 72 h from contact allergic...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics