Authors' reply

Bhagat, L; Saluja, A.K.
March 2003
Gut;Mar2003, Vol. 52 Issue 3, p453
Academic Journal
Replies to comments made by D.J. van Esterloo et al on the article 'Both thermal and non-thermal stress protect against caerulein induced pancreatitis and prevent trypsinogen activation in the pancreas,' published in the 2002 issue of the periodical 'Gut.' Suggestion that both heat shock stress and non-thermal stress can stimulate several other anti-inflammatory pathways.


Related Articles

  • Caerulein induced pancreatitis. van Westerloo, D.J.; Maris, N.A.; Bruno, M.J.; van der Poll, T. // Gut;Mar2003, Vol. 52 Issue 3, p452 

    Comments on the article 'Both thermal and non-thermal stress protect against caerulein induced pancreatitis and prevent trypsinogen activation in the pancreas,' by Frossard et al, published in the 2002 issue of the periodical 'Gut.' Suggestion that both heat shock stress and non-thermal stress...

  • Caerulein or taurocholate induced enzymatic and histologic alterations in the isolated perfused rat pancreas. Mantke, R.; Schubert, D.; Röcken, C.; Paege, I.; Halangk, W.; Peters, B.; Lippert, H.; Schulz, H-U. // Langenbeck's Archives of Surgery;Apr2009, Vol. 394 Issue 2, p363 

    Early events in the pathogenesis of experimental acute pancreatitis are intensively studied using isolated cells or animal models. However, the results and their interpretations are dependent on the complexity of biological structures. Therefore, we proposed that studies on isolated perfused...

  • Down-regulation of HSP60 expression by RNAi increases lipopolysaccharide- and cerulein-induced damages on isolated rat pancreatic tissues. Li, Yong-Yu; Lu, Shuai; Li, Kun; Feng, Jia-Yan; Li, Yan-Na; Gao, Zhi-Rong; Chen, Chang-Jie // Cell Stress & Chaperones;Winter2010, Vol. 15 Issue 6, p965 

    The objective of this study was to investigate the function of heat shock protein 60 (HSP60) on pancreatic tissues by applying HSP60 small interfering RNA (siRNA) to reduce HSP60 expression. Rat pancreas was isolated and pancreatic tissue snips were prepared, cultured, and stimulated with low...

  • Acute pancreatitis in Soweto, South Africa: relationship between trypsinogen load, trypsinogen activation, and fibrinolysis. Segal, Isidor; Chaloner, Christopher; Douglas, Jessica; John, Klaus-Dieter; Zaidi, Amir; Cotter, Lawrence; Appelros, Stefan; Borgström, Anders; Braganza, Joan M. // American Journal of Gastroenterology;Apr2002, Vol. 97 Issue 4, p883 

    OBJECTIVE:It is not known why acute pancreatitis in Soweto, South Africa, pursues an aggressive course. We sought clues from circulating trypsinogen load at admission as marker of initial acinar injury, trypsinogen activation using the carboxypeptidase B activation peptide as surrogate,...

  • The role of store operated calcium entry in endocytic vacuole formation in pancreatic acinar cells. Collier, D.; Sutton, R.; Tepikin, A.; Voronina, S. // Proceedings of the Physiological Society;2013, p331P 

    The intracellular activation of trypsinogen in pancreatic acinar cells is an early and probably initiating event in the development of acute pancreatitis (a frequent and life-threatening inflammatory disease). Endocytic vacuoles are the site of trypsinogen activation in pancreatic acinar cells...

  • Chemopreventive effects of resveratrol in a rat model of cerulein-induced acute pancreatitis. Carrasco, Cristina; Holguín-Arévalo, María; Martín-Partido, Gervasio; Rodríguez, Ana; Pariente, José // Molecular & Cellular Biochemistry;Feb2014, Vol. 387 Issue 1/2, p217 

    In the past decades, a greater understanding of acute pancreatitis has led to improvement in mortality rates. Nevertheless, this disease continues to be a health care system problem due to its economical costs. Future strategies such as antioxidant supplementation could be very promising,...

  • Autocrine Sonic Hedgehog Attenuates Inflammation in Cerulein-Induced Acute Pancreatitis in Mice via Upregulation of IL-10. Xiangyu Zhou; Zhiqiang Liu; Feng Jang; Chuannan Xiang; Yuan Li; Yanzheng He; Castresana, Javier S. // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    Hedgehog signaling plays critical roles in pancreatic oncogenesis and chronic pancreatitis, but its roles in acute pancreatitis (AP) are largely ambiguous. In this study, we provide evidence that Sonic hedgehog (Shh), but neither Desert hedgehog (Dhh) nor Indian hedgehog (Ihh), is the main...

  • Origin and implication of the hereditary pancreatitis-associated N21I mutation in the cationic trypsinogen gene. Jian-Min Chen; Ferec, Claude // Human Genetics;Jan2000, Vol. 106 Issue 1, p125 

    The N21I missense mutation in the cationic trypsinogen gene is the second most frequent mutation in hereditary pancreatitis (HP). In this article, we suggest that the N21I mutation most likely arose as a gene conversion event in which the functional anionic trypsinogen gene acted as the donor...

  • Evocative Test of Serum Pancreatic Enzymes to Bombesin in Chronic Pancreatitis. Andriulli, A.; Masoero, G.; Fico, D.; Zago, P.; Marchetto, M. // American Journal of Gastroenterology;Jul1986, Vol. 81 Issue 7, p562 

    The levels of serum immunoreactive trypsinogen and P-isoamylase in response to Bombesin intravenous infusion were evaluated in 25 controls, 18 patients with documented chronic pancreatitis, and nine subjects with nonpancreatic gastroenterological diseases. Mean immunoreactive trypsinogen peak...


Read the Article


Sign out of this library

Other Topics