TITLE

Overexpression of MAGE-D4 in colorectal cancer is a potentially prognostic biomarker and immunotherapy target

AUTHOR(S)
Qing-Mei Zhang; Shu-Jia He; Ning Shen; Bin Luo; Rong Fan; Jun Fu; Guo-Rong Luo; Su-Fang Zhou; Shao-Wen Xiao; Xiao-Xun Xie
PUB. DATE
July 2014
SOURCE
International Journal of Clinical & Experimental Pathology;2014, Vol. 7 Issue 7, p3918
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
97436136

 

Related Articles

  • ANGIOGENESIS-BASED PROGNOSTIC MARKERS IN IMMUNOHISTOCHEMISTRY FOR COLORECTAL CANCER PATIENTS. Ciocâlteu, Adriana; Săftoiu, Adrian; Pirici, Daniel; Cristea, Cosmin; Georgescu, Claudia-Valentina // Internal Medicine / Medicina Interna;2015, Vol. 12 Issue 4, p19 

    Angiogenesis plays a key role in the development and dissemination of colorectal cancer. In advanced stages this malignancy has a poor prognosis due to the inefficacy of the existent treatment and at this point the outcome cannot be completely predicted by common prognostic factors such as lymph...

  • Therapeutic Cancer Vaccines in Prostate Cancer: The Quest for Intermediate Markers of Response. Kim, Joseph W.; Bilusic, Marijo; Heery, Christopher J.; Madan, Ravi A. // Cancers;Dec2012, Vol. 4 Issue 4, p1229 

    Despite recent advances in cancer immunotherapy, no prospectively validated intermediate biomarkers exist to predict response. These biomarkers are highly desirable given modern immunotherapy's paradoxical pattern of clinical benefit; that is, improvement in overall survival without short-term...

  • Overexpression of MAGE-A9 Is Predictive of Poor Prognosis in Epithelial Ovarian Cancer. Xu, Yunzhao; Wang, Chenyi; Zhang, Yuquan; Jia, Lizhou; Huang, Jianfei // Scientific Reports;7/17/2015, p12104 

    The cancer testis antigen, melanoma-associated antigen A9 (MAGE-A9), is expressed in many kinds of different human cancers, and is an important target for immunotherapy. However, the clinicopathologic significance of MAGE-A9 in epithelial ovarian cancer (EOC) is unknown. In this study, real-time...

  • MAGE-C2/CT10 Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer. Von Boehmer, Lotta; Keller, Lukas; Mortezavi, Ashkan; Provenzano, Maurizio; Sais, Giovanni; Hermanns, Thomas; Sulser, Tullio; Jungbluth, Achim A.; Old, Lloyd J.; Kristiansen, Glen; Broek, Maries Van Den; Moch, Holger; Knuth, Alexander; Wild, Peter J. // PLoS ONE;2011, Vol. 6 Issue 7, p1 

    The cancer-testis (CT) family of antigens is expressed in a variety of malignant neoplasms. In most cases, no CT antigen is found in normal tissues, except in testis, making them ideal targets for cancer immunotherapy. A comprehensive analysis of CT antigen expression has not yet been reported...

  • Overexpression of melanoma-associated antigen D4 is an independent prognostic factor in squamous cell carcinoma of the esophagus. Oya, H.; Kanda, M.; Takami, H.; Hibino, S.; Shimizu, D.; Niwa, Y.; Koike, M.; Nomoto, S.; Yamada, S.; Nishikawa, Y.; Asai, M.; Fujii, T.; Nakayama, G.; Sugimoto, H.; Fujiwara, M.; Kodera, Y. // Diseases of the Esophagus;Feb2015, Vol. 28 Issue 2, p188 

    To pursue an urgently needed treatment target for esophageal cancer ( EC), we investigated the function of the recently discovered melanoma-associated antigen ( MAGE)- D4 in squamous cell EC. MAGE- D4 messenger RNA ( mRNA) expression was analyzed in nine EC cell lines using quantitative reverse...

  • Biomarkers in Advanced Colorectal Cancer: Challenges in Translating Clinical Research into Practice. Lemech, Charlotte; Arkenau, Hendrik-Tobias // Cancers;2011, Vol. 3 Issue 2, p1844 

    The growing number of therapeutic agents and known molecular targets in oncology makes the study and clinical use of biomarkers imperative for improving response and survival, reducing toxicity and ensuring economic sustainability. Colorectal cancer, among others, is at the forefront of...

  • Combined analysis of KRAS and PIK3CA mutations, MET and PTEN expression in primary tumors and corresponding metastases in colorectal cancer. Voutsina, Alexandra; Tzardi, Maria; Kalikaki, Aristea; Zafeiriou, Zafeiris; Papadimitraki, Elsa; Papadakis, Michael; Mavroudis, Dimitris; Georgoulias, Vassilis // Modern Pathology;Feb2013, Vol. 26 Issue 2, p302 

    No abstract available.

  • Established and Potential Predictive Biomarkers in Gastrointestinal Cancer - c-Kit, Her2, Ras and Beyond. Koch, Christine; Trojan, Joerg // Digestion;Jun2015, Vol. 91 Issue 4, p294 

    Background: Gastrointestinal cancers are among the leading causes of cancer-related deaths worldwide. In different tumor types, personalized systemic treatment strategies based upon biomarker-selection were established over the last years. Although there is a flood of targeted agents in clinical...

  • Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma. Zhao-lei Zeng; Wen-jing Wu; Jing Yang; Zhen-jie Tang; Dong-liang Chen; Miao-zhen Qiu; Hui-yan Luo; Zhi-qiang Wang; Ying Jin; De-shen Wang; Rui-hua Xu // Journal of Translational Medicine;2012, Vol. 10 Issue 1, p181 

    Background: Melanoma antigen D1 (MAGED1) is a member of the type II melanoma antigen (MAGE) family. The down-regulation of MAGED1 expression has been shown in breast carcinoma cell lines and in glioma stem cells and may play an important role in apoptosis and anti-tumorigenesis. However, there...

  • Expression and prognostic significance of cancer-testis antigens (CTA) in intrahepatic cholagiocarcinoma. Jin-xue Zhou; Yin Li; Sun-xiao Chen; An-mei Deng // Journal of Experimental & Clinical Cancer Research (17569966);2011, Vol. 30 Issue 1, p1 

    Background: Cancer-testis antigens (CTAs) are suitable targets for cancer-specific immunotherapy. The aim of the study is to investigate the expression of CTAs in intrahepatic cholagiocarcinoma (IHCC) and evaluate their potential therapeutic values. Methods: Eighty-nine IHCC patients were...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics