Clinical value of CD133 and nestin in patients with glioma: a population-based study

Dahlrot, Rikke H.; Hansen, Steinbjørn; Jensen, Stine S.; Schrøder, Henrik D.; Hjelmborg, Jacob; Kristensen, Bjarne W.
July 2014
International Journal of Clinical & Experimental Pathology;2014, Vol. 7 Issue 7, p3739
Academic Journal
No abstract available.


Related Articles

  • P04.09 THE PROGNOSTIC POTENTIAL OF CD133 AND NESTIN IN A POPULATION-BASED COHORT OF GLIOMA PATIENTS. Dahlrot, R.H.; Hansen, S.; Schroeder, H.D.; Jensen, S.S.; Hjelmborg, J.; Kristensen, B.W. // Neuro-Oncology;Sep2014 Supplement, Vol. 16 Issue suppl_2, pii38 

    INTRODUCTION: Cancer stem cell-related (CSC) markers like CD133 and nestin have been suggested as a novel type of prognostic markers in gliomas. However no single CSC-related marker is currently used in clinical decisions. The aim of this study was to investigate the prognostic potential of...

  • Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients. Byung Ho Kong; Ju HyungMoon; Yong-Min Huh; Jin-Kyoung Shim; Ji-Hyun Lee; Eui-Hyun Kim; Jong Hee Chang; Dong-Seok Kim; Yong-Kil Hong; Sun Ho Kim; Su-Jae Lee; Seok-Gu Kang // Stem Cells International;2014, p1 

    Cancer stem cells (CSCs) have been reported to be critical in the initiation, maintenance, and progression of cancers. The expression of stem cell markers, such as podoplanin (PDPN), CD133, and nestin, may have been correlated with malignant progression. However, the effects of CSCs and stem...

  • The prognostic value of nestin expression in newly diagnosed glioblastoma: Report from the Radiation Therapy Oncology Group. Chinnaiyan, Prakash; Meihua Wang; Rojiani, Amyn M.; Tofilon, Philip J.; Chakravarti, Arnab; Kian Ang, K.; Hua-Zhong Zhang; Hammond, Elizabeth; Curran Jr., Walter; Mehta, Minesh P. // Radiation Oncology;2008, Vol. 3, Special section p1 

    Background: Nestin is an intermediate filament protein that has been implicated in early stages of neuronal lineage commitment. Based on the heterogeneous expression of nestin in GBM and its potential to serve as a marker for a dedifferentiated, and perhaps more aggressive phenotype, the...

  • Malignant clinical features of anaplastic gliomas without IDH mutation. Shibahara, Ichiyo; Sonoda, Yukihiko; Shoji, Takuhiro; Kanamori, Masayuki; Saito, Ryuta; Inoue, Tomoo; Kawaguchi, Tomohiro; Yamashita, Yoji; Watanabe, Takashi; Kumabe, Toshihiro; Watanabe, Mika; Suzuki, Hiroyoshi; Tominaga, Teiji // Neuro-Oncology;Jan2015, Vol. 17 Issue 1, p136 

    Background Diagnosis of WHO grade III anaplastic gliomas does not always correspond to its clinical outcome because of the isocitrate dehydrogenase (IDH) gene status. Anaplastic gliomas without IDH mutation result in a poor prognosis, similar to grade IV glioblastomas. However, the malignant...

  • Expression of Tumor-Associated Macrophage in Progression of Human Glioma. Ding, Peng; Wang, Weimin; Wang, Jinkun; Yang, Zhiyong; Xue, Liping // Cell Biochemistry & Biophysics;Dec2014, Vol. 70 Issue 3, p1625 

    The aim of this study is to investigate the expression of tumor-associated macrophages (TAMs) M1, M2 phenotypic in human glioma tissues, and to explore the clinical significance and prognostic value of TAMs in glioma patients. A total of 50 glioma samples were obtained from patients diagnosed in...

  • The Fruits of Maclura pomifera Extracts Inhibits Glioma Stem-Like Cell Growth and Invasion. Zhao, Dan; Yao, Chengyun; Chen, Xiaobing; Xia, Hongping; Zhang, Li; Liu, Huixiang; Jiang, Xiaochun; Dai, Yi; Liu, Jun // Neurochemical Research;Oct2013, Vol. 38 Issue 10, p2105 

    Glioma is the most common primary intracranial tumour. Recently, growing evidence showed that glioma possesses stem-like cells, which are thought to be chemo- and radio-resistant and believed to contribute to the poor clinical outcomes of these tumours. In this study, we found that stem-like...

  • MiR-34a induces apoptosis of glioma stem cells via the inhibition of SIRT1. Xiaoyong Fan; Jianjun Wang; Youqiang Cui; Guangcun Liu // International Journal of Clinical & Experimental Medicine;2016, Vol. 9 Issue 10, p9715 

    Neuroglioma is one common intracranial tumor with high incidence and mortality. The role of microRNA (miR)-34a in glioma has been recognized, but its biological property in glioma as well as tumor stem cells remains unknown. This study aimed to investigate the expression of miR-34a in...

  • Identification of CD133+ Cells in Pituitary Adenomas. Yunoue, Shunji; Arita, Kazunori; Kawano, Hiroto; Uchida, Hiroyuki; Tokimura, Hiroshi; Hirano, Hirofumi // Neuroendocrinology;Dec2011, Vol. 94 Issue 4, p302 

    Stem-like cells in tumors are capable of self-renewal and pluri-differentiation; they are thought to play important roles in tumor initiation and maintenance. Stem-like cells in malignant glioma express CD133. We examined samples from human pituitary adenoma, a generally benign neoplasm, for...

  • Tumour-infiltrating CD4+ and CD8+ lymphocytes as predictors of clinical outcome in glioma. Han, S; Zhang, C; Li, Q; Dong, J; Liu, Y; Huang, Y; Jiang, T; Wu, A // British Journal of Cancer;5/13/2014, Vol. 110 Issue 10, p2560 

    Background:T lymphocyte infiltration has been detected in glioma, although its significance remains unclear. The purpose of the present study was to explore the prognostic value of CD4+ and CD8+ tumour-infiltrating lymphocytes (TILs) in glioma, and the prognostic value of infiltrating Forkhead...

  • Nestin expression as an independent indicator of poor prognosis for patients with anaplastic thyroid cancer. KENTO KURATA; NAOYOSHI ONODA; SATORU NODA; SHINICHIRO KASHIWAGI; YUKA ASANO; HIDEMI KAWAJIRI; TSUTOMU TAKASHIMA; SAYAKA TANAKA; MASAHIKO OHSAWA; KOSEI HIRAKAWA // Oncology Letters;Aug2015, Vol. 10 Issue 2, p850 

    The protein nestin, a neuronal stem cell marker, has been reported to indicate a poor prognosis in various tumours. Anaplastic thyroid cancer (ATC) is one of the most aggressive malignancies in humans, and its molecular background has not been identified. The present study evaluated the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics