RNAi-mediated silencing of the Skp-2 gene causes inhibition of growth and induction of apoptosis in human renal carcinoma cells

Hongsheng Lu; Meifu Gan; Xuequan Cao; Lanxi Chen; Zhaohui Yang; Wei Hu
July 2014
International Journal of Clinical & Experimental Pathology;2014, Vol. 7 Issue 7, p3845
Academic Journal
No abstract available.


Related Articles

  • FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2. Tao Zuo; Runhua Liu; Huiming Zhang; Xing Chang; Yan Liu; Lizhong Wang; Pan Zheng; Yang Liu // Journal of Clinical Investigation;Dec2007, Vol. 117 Issue 12, p3765 

    S-phase kinase-associated protein 2 (SKP2) is a component of the E3 ubiquitin ligase SKP1-Cul1-Fbox complex. Overexpression of SKP2 results in cell cycle dysregulation and carcinogenesis; however, the genetic lesions that cause this upregulation are poorly understood. We recently demonstrated...

  • Downregulation of Skp2 and p27/Kip1 synergistically induces apoptosis in T98G glioblastoma cells. Sang Hyun Lee; McCormick, Frank // Journal of Molecular Medicine;Apr2005, Vol. 83 Issue 4, p296 

    S-Phase kinase associated protein (Skp) 2 is an F-box protein required for substrate recognition of the SCFSkp2 ubiquitin ligase complex. Skp2 is often overexpressed in transformed cells and in various types of tumors. Downregulation or inhibition of Skp2 inhibits growth of breast cancer cells...

  • Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference. Sumimoto, H; Yamagata, S; Shimizu, A; Miyoshi, H; Mizuguchi, H; Hayakawa, T; Miyagishi, M; Taira, K; Kawakami, Y // Gene Therapy;Jan2005, Vol. 12 Issue 1, p95 

    Increase of Skp-2, which is involved in the degradation of cell cycle regulators including p27Kip1, p21 and c-myc, is one of the important mechanisms for dysregulation of cell cycles in various cancers. We applied RNA interference (RNAi) for Skp-2 by using HIV-lentiviral or adenoviral vectors...

  • Silencing of HIF-1α suppresses tumorigenicity of renal cell carcinoma through induction of apoptosis. Xu, K.; Ding, Q.; Fang, Z.; Zheng, J.; Gao, P.; Lu, Y.; Zhang, Y. // Cancer Gene Therapy;Mar2010, Vol. 17 Issue 3, p212 

    Hypoxia-inducible factor-1α (HIF-1α) is a main responder to intracellular hypoxia and is overexpressed in many human cancers, including renal cell carcinoma (RCC). To better understanding of the role of HIF-1α in the tumorigenicity of RCC, we used short-hairpin RNA (shRNA) interference...

  • siRNA KNOCKDOWN SKP2 GENE IN BREAST CANCER. Abdel-Mageed, Wael S. // Egyptian Journal of Biochemistry & Molecular Biology;Dec2016, Vol. 34 Issue 1-2, p3 

    The S-phase kinase-associated protein-2 (SKP2) plays a strategic role in ubiquitin-mediated proteolysis, which effects in the development of cells from inactivity to proliferative state. SKP2 is overexpressed in a variety of tumor. In this study, we used small interfering RNAs (siRNAs) to...

  • ShRNA-Targeted Centromere Protein A Inhibits Hepatocellular Carcinoma Growth. Yongmei Li; Zhi Zhu; Shuhui Zhang; Danghui Yu; Hongyu Yu; Lina Liu; Xiaozhe Cao; Li Wang; Hengjun Gao; Minghua Zhu // PLoS ONE;2011, Vol. 6 Issue 3, p1 

    Background: Centromere protein A (CENP-A) plays important roles in cell-cycle regulation and genetic stability. Herein, we aimed to investigate its expression pattern, clinical significance, and biological function in hepatocellular carcinoma (HCC). Methodology/Principal Findings: CENP-A...

  • RNA Interference-Mediated Validation of Survivin and Apollon/BRUCE as New Therapeutic Targets for Cancer Therapy. Pennati, Marzia; Millo, Enrico; Gandellini, Paolo; Folini, Marco; Zaffaroni, Nadia // Current Topics in Medicinal Chemistry;Jan2012, Vol. 12 Issue 2, p69 

    The ability to evade apoptosis is one of the defining hallmarks of cancer. It enables the survival of cancer cells under abnormal growth stimulation and mediates their increased resistance to treatment with cytotoxic drugs and radiation. Therefore, antiapoptotic proteins that counteract...

  • von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage. Roe, J-S; Kim, H-R; Hwang, I-Y; Cho, E-J; Youn, H-D // Oncogene;7/14/2011, Vol. 30 Issue 28, p3127 

    Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene cause VHL disease, a rare and autosomal-dominant genetic syndrome. Because VHL protein (pVHL) is the master regulator of hypoxia-inducible factor alpha (HIFα), the most prominent feature of VHL disease is the deregulation...

  • Identification of cellular targets for the human papillomavirus E6 and E7 oncogenes by RNA interference and transcriptome analyses. Kuner, Ruprecht; Vogt, Markus; Sultmann, Holger; Buness, Andreas; Dymalla, Susanne; Bulkescher, Julia; Fellmann, Mark; Butz, Karin; Poustka, Annemarie; Hoppe-Seyler, Felix // Journal of Molecular Medicine;Nov2007, Vol. 85 Issue 11, p1253 

    Specific types of human papillomaviruses (HPVs) cause cervical cancer, the second most common tumor in women worldwide. Both cellular transformation and the maintenance of the oncogenic phenotype of HPV-positive tumor cells are linked to the expression of the viral E6 and E7 oncogenes. To...

  • Gene silencing of ß-catenin by RNAi inhibits cell proliferation in human esophageal cancer cells in vitro and in nude mice. Jin-Sheng Wang; Chang-Li Zheng; Yong-Jin Wang; Ji-Fang Wen; Hong-Zheng Ren; Ying Liu; Hai-Ying Jiang // Diseases of the Esophagus;Apr2009, Vol. 22 Issue 2, p151 

    ß-catenin, which is frequently overexpressed in a variety of human cancers including esophageal cancer, mediates cancer cell proliferation and tumor growth. In the present study, we used a human U6 promoter-driven DNA-template approach to induce short hairpin RNA (shRNA)-triggered RNA...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics