TITLE

Nanoengineered mesoporous silica nanoparticles for smart delivery of doxorubicin

AUTHOR(S)
Mishra, Akhilesh; Pandey, Himanshu; Agarwal, Vishnu; Ramteke, Pramod; Pandey, Avinash
PUB. DATE
August 2014
SOURCE
Journal of Nanoparticle Research;Aug2014, Vol. 16 Issue 8, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The motive of the at hand exploration was to contrive a proficient innovative pH-responsive nanocarrier designed for an anti-neoplastic agent that not only owns competent loading capacity but also talented to liberate the drug at the specific site. pH sensitive hollow mesoporous silica nanoparticles (~MSN) have been synthesized by sequence of chemical reconstruction with an average particle size of 120 nm. ~MSN reveal noteworthy biocompatibility and efficient drug loading magnitude. Active molecules such as Doxorubicin (DOX) can be stocked and set free from the pore vacuities of ~MSN by tuning the pH of the medium. The loading extent of ~MSN was found up to 81.4 wt% at pH 7.8. At mild acidic pH, DOX is steadily released from the pores of ~MSN. Both, the nitrogen adsorption-desorption isotherms and X-ray diffraction patterns reflects that this system holds remarkable stable mesostructure. Additionally, the outcomes of cytotoxicity assessment further establish the potential of ~MSN as a relevant drug transporter which can be thought over an appealing choice to a polymeric delivery system.
ACCESSION #
97432899

 

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