High-resolution CT in chronic pulmonary changes after mustard gas exposure

Bagheri, M. H.; Hosseini, S. K.; Mostafavi, S. H.; Alavi, S. A.
May 2003
Acta Radiologica;May2003, Vol. 44 Issue 3, p241
Academic Journal
journal article
Purpose: To identify the findings of high-resolution CT (HRCT) of the lung in patients with previous sulfur mustard gas exposure, and to correlate these findings with clinical and chest X-ray (CXR) results. Material and Methods: 50 consecutive patients were studied prospectively. The clinical data were recorded. Standard p.a. CXR and HRCT of the lung and spirometry were performed. The findings of CXR, HRCT and clinical and spirometry results were scored between 0 and 3 according to the severity of the findings. Results: HRCT abnormality was detected in all 50 patients (100%), while CXR was abnormal in 40 patients (80%). The most common HRCT findings was airway abnormalities (bronchial wall thickening in 100% of cases). Other important findings were suggestive of interstitial lung disease (ILD) (80%), bronchiectasis (26%), and emphysema (24%). A statistically significant correlation was found between the severity of clinical presentation and that of the HCTR scores in patients with bronchiectasis, bronchitis and ILD (p< 0.05), but not with severity scores of HRCT in patients with emphysema. No significant correlation was found between severity scores of CXR findings. HRCT evidence of bronchial wall thickening and with a lower frequency ILD were present despite normal CXR in 20% of the patients. Conclusion: The results of this study suggest that bronchial wall thickening, ILD and emphysema are common chronic pulmonary sequelae of sulfur mustard injury. HRCT of the chest should be considered as the imaging modality of choice in chemical war injury.


Related Articles

  • Chemical Warfare in the 1920s & 30s. Balfour, Sebastian // History Today;Jun2002, Vol. 52 Issue 6, p2 

    Highlights the use of chemical warfare in the 1920s and 1930s by European countries. Effects of chemical warfare on human beings; Deployment of mustard gas by the British soldiers; Use of mustard gas by the Italian against the Ethiopians in 1936.

  • MUSTY MEMORIES OF JAPANESE WAR CRIMES ARE AIRED IN CHINA.  // Bulletin with Newsweek;9/2/2003, Vol. 121 Issue 6388, p14 

    This article describes the incident of mustard gas barrel leakage which occurred in the north-eastern Chinese city of Qiqihar in the month of September 2003. A man died and some 40 others were hospitalized after the barrels began to leak. The gas was part of a stockpile of an estimated 700,000...

  • Diisopropylglutathione ester protects A549 cells from the cytotoxic effects of sulphur mustard. Lindsay, C.D.; Hambrook, J.L. // Human & Experimental Toxicology;1998, Vol. 17 Issue 11, p606 

    The A549 cell line was used to assess the ability of diisopropylglutathione (DIPE) to protect against a 100 μM challenge dose of sulphur mustard (HD) using gentian violet (GV), thiazolyl blue (MTT) and neutral red (NR) assays as indicators of cell culture viability. As part of a continuing...

  • An in vitro comparison of the cytotoxicity of sulphur mustard in melanoma and keratinocyte cell lines. Smith, C.N.; Lindsay, C.D.; Hambrook, J.L. // Human & Experimental Toxicology;Sep2001, Vol. 20 Issue 9, p483 

    In vivo, the pigment producing melanocytes are the most susceptible cell type to sulphur mustard (HD) in the epidermal region of pig skin. It has been postulated that this is due to the melanogenic pathway producing a cytotoxic, free radical cascade within the melanocyte following HD poisoning,...

  • Port Arthur Revisited. Connaughton, Richard // History Today;Jan2002, Vol. 52 Issue 1, p2 

    Traces the history of Port Arthur, battlefield of the Russo-Japanese War in China. Reason behind the war; Impact of the Russo-Japanese conflict on the Second World War.

  • HOLD THE MUSTARD. McManus, Reed // Sierra;Jul/Aug2002, Vol. 87 Issue 4, p63 

    Focuses on the bug method of mixing the components with warm water to deactive deadly mustard gas, introduced by Rocky Mountain Chapter activist Ross Vincent.

  • High-resolution CT in chronic pulmonary changes after mustard gas exposure. Hemmingsson, Anders // Acta Radiologica;May2003, Vol. 44 Issue 3, p240 

    Cites an article by M.H. Bagheri and colleagues about lung lesions as sequelae of mustard gas exposure in persons surviving in the Shiraz region of Iran in 1982-88, published in the May 2003 issue of 'Acta Radiologica.' Description of the lesions.

  • The Government Experiment That Tested Mustard Gas on 'Black Skins' (MuckReads Weekly). Parris Jr., Terry // Pro Publica;Jun2015, p1 

    The article mentions the posts from the readers of the investigative news company, ProPublica, regarding the article which reported the U.S. Government decision of testing the mustard gas on the Blacks and other minorities.

  • Protection of human upper respiratory tract cell lines against sulphur mustard toxicity by glutathione esters. Andrew, D.J.; Lindsay, C.D. // Human & Experimental Toxicology;1998, Vol. 17 Issue 7, p387 

    1 Human and animal lung cells have been used successfully to model the toxic effects of inhaled sulphur mustard (HD). The epithelia of the upper respiratory tract are, however, the primary targets of inhaled HD. The aim of this study was to assess the potential of the mono- and di-isopropyl...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics