TITLE

Protective role of appendicectomy on onset and severity of ulcerative colitis and Crohn's disease

AUTHOR(S)
Radford-Smith, G.L.; Edwards, J.E.; Purdie, D.M.; Pandeya, N.; Watson, M.; Martin, N.G.; Green, A.; Newman, B.; Florin, T.H.J.
PUB. DATE
December 2002
SOURCE
Gut;Dec2002, Vol. 51 Issue 6, p808
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and aims: Recent studies on appendicectomy rates in ulcerative colitis and Crohn's disease have generally not addressed the effect of appendicectomy on disease characteristics. The aims of this study were to compare appendicectomy rates in Australian inflammatory bowel disease patients and matched controls, and to evaluate the effect of prior appendicectomy on disease characteristics. Methods: Patients were ascertained from the Brisbane Inflammatory Bowel Disease database. Controls matched for age and sex were randomly selected from the Australian Twin Registry. Disease characteristics included age at diagnosis, disease site, need for immunosuppression, and intestinal resection. Results: The study confirmed the significant negative association between appendicectomy and ulcerative colitis (odds ratio (OR) 0.23, 95% confidence interval (CI) 0.14-0.38; p<0.0001) and found a similar result for Crohn's disease once the bias of appendicectomy at diagnosis was addressed (OR 0.34, 95% CI 0.23-0.51; p<0.0001). Prior appendicectomy delayed age of presentation for both diseases and was statistically significant for Crohn's disease (p=0.02). In ulcerative colitis, patients with prior appendicectomy had clinically milder disease with reduced requirement for immunosuppression (OR 0.15, 95% CI 0.02-1.15; p=0.04) and proctocolectomy (p=0.02). Conclusions: Compared with patients without prior appendicectomy, appendicectomy before diagnosis delays disease onset in ulcerative colitis and Crohn's disease and gives rise to a milder disease phenotype in ulcerative colitis.
ACCESSION #
9737552

 

Related Articles

  • Appendix redux. Sachar, D.B. // Gut;Dec2002, Vol. 51 Issue 6, p764 

    Comments on research on the protective effect of appendicectomy against the incidence of ulcerative colitis and Crohn's disease. Research design; Epidemiological factors that work in opposite directions in the two conditions; Course of ulcerative colitis following a history of appendicectomy.

  • The role of appendicectomy in the subsequent development of inflammatory bowel disease: a UK-based study. Singhal, Rishi; Taylor, Jevan; Owoniyi, Muyiwa; El-Khayat, Rami; Tyagi, Satyendra; Corfield, Andrew // International Journal of Colorectal Disease;Apr2010, Vol. 25 Issue 4, p509 

    Several studies have shown an inverse relationship between appendicectomy and subsequent development of inflammatory bowel disease (IBD), although these findings remain contentious. This study aims to further elucidate the role appendicitis/appendicectomy has in the development of IBD. All...

  • Effects of appendicectomy on the course of ulcerative colitis. Cosnes, J.; Carbonnel, F.; Beaugerie, L.; Blain, A.; Reijasse, D.; Gendre, J.-P. // Gut;Dec2002, Vol. 51 Issue 6, p803 

    Background: Appendicectomy reduces the risk of having ulcerative colitis. However, its effect on the natural history of ulcerative colitis remains uncertain. Aim: To determine whether appendicectomy reduces the overall severity of ulcerative colitis. Patients and methods: Appendicectomy status...

  • Appendectomy Protects Against the Development of Ulcerative Colitis and Reduces Its Recurrence: Results of a Multicenter Case-Controlled Study in Japan. Naganuma, Makoto; Iizuka, Ben-ei; Torii, Akira; Ogihara, Tatsuo; Kawamura, Yo; Ichinose, Masao; Yasuaki, Kojima; Hibi, Toshifumi // American Journal of Gastroenterology;Apr2001, Vol. 96 Issue 4, p1123 

    OBJECTIVES: Studies in the US and Europe have shown that appendectomy may prevent the development of ulcerative colitis, but no detailed study has been conducted in Japan, where ulcerative colitis is uncommon and the population is racially homogeneous. In addition, there has been no detailed...

  • Appendicectomy has no beneficial effect on admission rates in patients with ulcerative colitis. Hallas, J.; Gaist, D.; Vach, W.; Sørensen, H. T. // Gut;Mar2004, Vol. 53 Issue 3, p351 

    Background and aims: Those who have had an appendicectomy have a reduced risk of developing ulcerative colitis. However, the effect of appendicectomy on disease activity in patients with ulcerative colitis has not been established. Methods: We used the Danish National Patient Registry to...

  • Appendectomy, tonsillectomy, and risk of inflammatory bowel disease: a case control study in Iran. Firouzi, Farzad; Bahari, Ali; Aghazadeh, Rahim; Zali, Mohammad Reza // International Journal of Colorectal Disease;Mar2006, Vol. 21 Issue 2, p155 

    There is some controversy about the prevalence of appendectomy and tonsillectomy among patients with Crohn’s disease and a lower rate of appendectomy among patients with ulcerative colitis (UC). The objective of this study was to elucidate the role of appendectomy and tonsillectomy in...

  • And So the Worm Turns.  // Medical Update;Nov99, Vol. 23 Issue 5, p3 

    Focuses on the research at the University of Iowa which stated that modern advances in hygiene may be contributing to the increase of Crohn's disease and ulcerative colitis in industrialized countries.

  • Prognosis of colonic Crohn's disease. Elliott, P.R.; Ritchie, J.K.; Lennard-Jones, J.E. // British Medical Journal (Clinical Research Edition);7/20/1985, Vol. 291 Issue 6489, p178 

    Reports the prognosis of colonic Crohn's disease. Comparisons between Crohn's disease and ulcerative colitis; Information on the surgical treatment of Crohn's disease; Features of regional enteritis.

  • Breakfast and Crohn's disease-II. Archer, L.N.J.; Harvey, Richard F. // British Medical Journal;8/19/1978, Vol. 2 Issue 6136, p540 

    Part II. Examines the breakfast habits of patients with Crohn's disease and ulcerative colitis in Great Britain. Importance of dietary factors in the aetiology of Crohn's disease; Emphasis on cornflake eating of patients; Absence of evidence on the association of diseases with cornflakes...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics