TPMT in the treatment of inflammatory bowel disease with azathioprine
- Author's reply. Lennard, L. // Gut;May2003, Vol. 52 Issue 5, p767
Replies to comments on the article concerning the role of thiopurine methyltransferase (TPMT) enzyme in predicting azathioprine related toxicity in patients with inflammatory bowel disease, previously published in the periodical 'Gut.' Methods of measuring TPMT; Risk of azathioprine toxicity.
- Corrigendum: PACSIN2 Does Not Influence Thiopurine-Related Toxicity in Patients With Inflammatory Bowel Disease. Roberts, Rebecca L; Wallace, Mary C; Seinen, Margien L; Krishnaprasad, Krupa; Chew, Angela; Lawrance, Ian; Prosser, Ruth; Bampton, Peter; Grafton, Rachel; Simms, Lisa; Radford-Smith, Graham; Andrews, Jane M; Barclay, Murray L // American Journal of Gastroenterology;Jan2015, Vol. 110 Issue 1, p204
A correction to the article "PACSIN2 does not influence thiopurine-related toxicity in patients with inflammatory bowel disease," published in a 2014 issue of the "American Journal of Gastroenterology" is presented.
- Successful Azathioprine Treatment with Metabolite Monitoring in a Pediatric Inflammatory Bowel Disease Patient Homozygous for TPMT*3C. Mi-Na Lee; Hye In Woo; Yoo Min Lee; Ben Kang; Jong-Won Kim; Yon Ho Choe; Soo-Youn Lee // Yonsei Medical Journal;Nov2013, Vol. 54 Issue 6, p1545
Thiopurine S-methyltransferase (TPMT) methylates purine analogues, showing TPMT activity in inverse relation to concentrations of active metabolites such as 6-thioguanine nucleotide (6-TGN). With conventional dosing of thiopurines, patients with homozygous variant TPMT alleles consistently...
- Azathioprine. // Reactions Weekly;6/7/2008, Issue 1205, p8
The article describes the case of a girl with Crohn's disease who developed cytomegalovirus (CMV) infection and pancytopenia, followed by paradoxical elevation of thiopurine-S-methyltransferase (TPMT) activity during treatment with azathioprine. The girl has undergone left hemicolectomy in the...
- Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment. Uchiyama, Kan; Nakamura, Makoto; Kubota, Takahiro; Yamane, Tateki; Fujise, Kiyotaka; Tajiri, Hisao // Journal of Gastroenterology;2009, Vol. 44 Issue 3, p197
The main cause of azathioprine (AZA)/6-mercaptopurine (6MP)-induced adverse reactions is a reduction in the activities of the metabolizing enzymes thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphohydrolase (ITPA). Adverse reactions develop at a high frequency in Japanese...
- Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. // Inflammatory Bowel Disease Monitor;2011, Vol. 11 Issue 3, p126
The article presents a study on the role of microRNAs (miRNAs) in inactive colonic mucosa of patients with inflammatory bowel disease (IBD).
- High prevalence of fatigue in quiescent inflammatory bowel disease is not related to adrenocortical insufficiency. Minderhoud, Itta M.; Oldenburg, Bas; van Dam, P. Sytze; van Berge Henegouwen, Gerard P. // American Journal of Gastroenterology;May2003, Vol. 98 Issue 5, p1088
: ObjectivesInflammatory bowel disease (IBD) patients, with active as well as quiescent disease, frequently complain of fatigue. This often has consequences for patientsâ€™ work and daily lives. The primary aim of this study was to assess the prevalence and severity of fatigue in IBD...
- Active inflammatory bowel disease greatly increased risk for VTE. Haigh, Christen; Harris, Jason; Lawerence, Leah; Southall, Jennifer // Hem/Onc Today;3/10/2010, Vol. 11 Issue 5, p31
This article focuses on a study which examined the risk for venous thromboembolism among nonhospitalized patients active inflammatory bowel disease.
- Screening and surveillance for asymptomatic colorectal cancer in IBD. Forbes, A.; Gabe, S.; Lennard-Jones, J.E.; Wilkinson, K. // Gut;May2003, Vol. 52 Issue 5, p769
Comments on the article concerning screening and surveillance for asymptomatic colorectal cancer in inflammatory bowel disease patients, previously published in the periodical 'Gut.' Arguments against the guidelines established by the British Society of Gastroenterology and Association of...