Cell migration: a novel aspect of pancreatic stellate cell biology
- Ghrelin Is Present in Pancreatic Î±-Cells of Humans and Rats and Stimulates Insulin Secretion. Date, Yukari; Nakazato, Masamitsu; Hashiguchi,, Suzuko; Dezaki, Katsuya; Mondal, Muhtashan S.; Hosoda, Hiroshi; Kojima, Masayasu; Kangawa, Kenji; Arima, Terukatsu; Matsuo, Hisayuki; Yada, Toshilfiko; Matsukura, Shigeru // Diabetes;Jan2002, Vol. 51 Issue 1, p124
Examines the presence of ghrelin in pancreatic alpha cells of humans and rats. Effects of ghrelin on insulin secretion; Description of growth hormone secretagogues; Cellular source of ghrelin in rat and human pancreas.
- Molecular basis of transdifferentiation of pancreas to liver. Shen, Chia-Ning; Slack, Jonathan M. W.; Tosh, David // Nature Cell Biology;Dec2000, Vol. 2 Issue 12, p879
The appearance of hepatic foci in the pancreas has been described in animal experiments and in human pathology. Here we show that pancreatic cells can be converted into hepatocytes by treatment with a synthetic glucocorticoid, dexamethasone. This occurs both in a pancreatic cell line, AR42J-B13,...
- Circulating Antibodies Against an Exocrine Pancreatic Enzyme in Type 1 Diabetes. Panicot, Laurence; Mas, Eric; Thivolet, Charles; Lombardo, Dominique // Diabetes;Dec99, Vol. 48 Issue 12, p2316
Identifies an autoantigen in type I diabetes originating from the exocrine pancreas. Presence of antibodies to bile salt-dependent lipase (BSDL) in type I diabetic patients; Prevalence of autoreactivity to BSDL in prediabetic and type I diabetic patients; Secretion pathway of BSDL.
- Localization of the O-Linked N-Acetylglucosamine Transferase in Rat Pancreas. Akimoto, Yoshihiro; Kreppel, Lisa K.; Hirano, Hiroshii; Hart, Gerald W. // Diabetes;Dec99, Vol. 48 Issue 12, p2407
Examines the localization of the O-linked N-acetylglucosamine transferase in rat pancreatic cells. Mediation of the hexosamine biosynthesis pathway in the glucose-induced desensitization of the glucose transport system and insulin resistance induction; Elevation of the hexosamine pathway in...
- Characterization of GPR56 protein and its suppressed expression in human pancreatic cancer cells. Yue Huang; Jun Fan // Molecular & Cellular Biochemistry;Jan2008, Vol. 308 Issue 1/2, p133
AbstractÃ‚Â Ã‚Â GPR56 is an atypical G protein-coupled receptor (GPCR) with an unusually large N-terminal extracellular region, which contains a long Ser/Thr-rich region forming a mucin-like stalk and due to this feature, GPR56 is thought to be an adhesion GPCR. Recent studies...
- Late presentation of a mucinous ovarian adenocarcinoma which was initially diagnosed as a primary pancreatic carcinoma: a case report and review of the literature. Sparks, Dorothy A.; Chase, Daniel M.; Forsyth, Mark; Bogen, Gregg; Arnott, Jon // Journal of Medical Case Reports;2010, Vol. 4 Issue 1, p1
Introduction: Adenocarcinoma of the ovary is an aggressive neoplasm which often metastasizes to the lung or liver. Metastases rarely occur to the pancreas, but a tissue diagnosis is required to confirm this event. Although most tumors of the pancreas are primary pancreatic neoplasms, metastatic...
- Pancreatic cancer: Tracing origins. Seton-Rogers, Sarah // Nature Reviews Cancer;Jan2013, Vol. 13 Issue 1, p5
The article focuses on pancreatic ductal adenocarcinoma (PDA) which has been used in mouse models for expressing the oncogenic KRAS in pancreatic cells.
- Pancreatic islet cell autophagy during aging in rats. Shuang Wang; Qian-qian Sun; Bing Xiang; Xiu-Jun Li // Clinical & Investigative Medicine;2013, Vol. 36 Issue 2, pE72
Purpose: Autophagy induces pancreatic Î² cell death. The purpose of the present study was to examine the hypothesis that the extent of pancreatic autophagy is associated with aging and age-related diabetes. Methods: Pancreatic tissue and blood samples were collected from Sprague Dawley rats...
- Advanced glycation end products impair glucose-induced insulin secretion from rat pancreatic Î²-cells. Hachiya, Hiroyuki; Miura, Yoshikazu; Inoue, Ken-ichi; Park, Kyung Hwa; Takeuchi, Masayoshi; Kubota, Keiichi // Journal of Hepato -- Biliary -- Pancreatic Sciences;Feb2014, Vol. 21 Issue 2, p134
Background Advanced glycation end products ( AGEs) are derivative compounds generated from non-enzymatic glycosylation and oxidation. In comparison with glucose-derived AGEs ( Glu- AGEs), glyceraldehyde-derived AGEs ( Glycer- AGEs) have stronger toxicity to living systems. In this study, we...