An Asia-Pacific, double blind, placebo controlled, randomised study to evaluate the efficacy, safety, and tolerability of tegaserod in patients with irritable bowel syndrome
- Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome. Houghton, L.A.; Atkinson, W.; Whitaker, R.P.; Whorwell, P.J.; Rimmer, M.J. // Gut;May2003, Vol. 52 Issue 5, p663
Background: Meal ingestion is often associated with exacerbation of gastrointestinal symptoms in subjects with irritable bowel syndrome (lBS). Furthermore, recent preliminary data suggest that 5-hydroxytryptamine (5-HT) concentration in platelet poor plasma is elevated following meal ingestion...
- Oesophageal motility in the irritable bowel syndrome. Whorwell, P.J.; Clouter, Carole; Smith, Colin L. // British Medical Journal (Clinical Research Edition);4/4/1981, Vol. 282 Issue 6270, p1101
Examines oesophageal motility to patients with irritable bowel syndrome. Importance of controls matched with age and sex; Features of patients with more than one abnormal pattern of motility; Symptoms of the disease.
- Central processing of rectal pain in patients with irritable bowel syndrome: an fMRI study. Bonaz, B.; Baciu, M.; Papillon, E.; Bost, R.; Gueddah, N.; Le Bas, J.-F.; Fournet, J.; Segebarth, C. // American Journal of Gastroenterology;Mar2002, Vol. 97 Issue 3, p654
OBJECTIVES:In healthy subjects, the neural correlates of visceral pain bear much similarity with the correlates of somatic pain. In patients with irritable bowel syndrome, the central nervous system is believed to play a strong modulatory or etiological role in the pathophysiology of the...
- Is there a difference between abdominal pain and discomfort in moderate to severe IBS patients? Sach, Joel; Bolus, Roger; Fitzgerald, Leah; Naliboff, Bruce D.; Chang, Lin; Mayer, Emeran A. // American Journal of Gastroenterology;Dec2002, Vol. 97 Issue 12, p3131
OBJECTIVES:The aims of this study were to: 1) determine the relative prevalence of self-reported pain-predominant and discomfort-predominant symptom patterns in irritable bowel syndrome (IBS) patients; and 2) test the hypotheses that pain-predominant patients report higher GI symptom severity,...
- Quality of Life in Irritable Bowel Syndrome. Lea, R.; Whorwell, P.J. // PharmacoEconomics;Jun2001, Vol. 19 Issue 6, p643
Quality-of-life (QOL) assessment is becoming increasingly important in the evaluation of the impact of disease and the effect of therapy. This is particularly so for irritable bowel syndrome (IBS) where there is often a tendency for a chronic clinical course, but with no associated mortality....
- Linzess for IBS, Constipation. // Monthly Prescribing Reference;Oct2012, Vol. 28 Issue 10, pA-8
The article reports on the drug approval for Linzess, a linaclotide drug capsule that can be used for the treatment of chronic idiopathic constipation and constipation associated in irritable bowel syndrome (IBS-C) in adults.
- Response to Rodrigo et al. Martinez, Cristina; Vicario, Maria; Santos, Javier // American Journal of Gastroenterology;Aug2014, Vol. 109 Issue 8, p1291
A letter to the editor is presented in response to the article in the previous issue about a study on molecular alterations in the tight junction signaling pathway in patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
- Response to Keszthelyi and Masclee. Wouters, M M; Balemans, D; Boeckxstaens, G E // American Journal of Gastroenterology;Aug2014, Vol. 109 Issue 8, p1286
A response to an article about the role of transient receptor potential vanilloid 1 (TRPV1) in the visceral hypersensitivity of irritable bowel syndrome (IBS) patients that was published in the previous issue is presented.
- Comments on 'The Jejunum of Diarrhea-Predominant Irritable Bowel Syndrome Shows Molecular Alterations in the Tight Junction Signaling Pathway That Are Associated With Mucosal Pathobiology and Clinical Manifestations'. Rodrigo, Luis; Lauret, E; Pérez, I; Suarez, A // American Journal of Gastroenterology;Aug2014, Vol. 109 Issue 8, p1290
A letter to the editor is presented in response to the article in the previous issue about the molecular alterations found at the level of the tight junctions in patients with diarrhea-predominant irritable bowel syndrome (IBS-D).