TITLE

Antineuronal antibodies in idiopathic achalasia and gastro-oesophageal reflux disease

AUTHOR(S)
Moses, P.L.; Ellis, L.M.; Anees, M.R.; Ho, W.; Rothstein, R.I.; Meddings, J.B.; Sharkey, K.A.; Mawe, G.M.
PUB. DATE
May 2003
SOURCE
Gut;May2003, Vol. 52 Issue 5, p629
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and aims: The precise aetiology of achalasia is unknown although autoimmunity has been implicated and is supported by several studies. We screened sera from patients with achalosia or gastro-oesophageal reflux disease (GORD) to test for circulating antimyenteric neuronal antibodies. Methods: Serum was obtained from 45 individuals with achalasia, 16 with GORD, and 22 normal controls. Serum was used in immunohistochemistry to label whole mount preparations of ileum and oesophagus of the guinea pig and mouse. Also, sections of superior cervical and dorsal root ganglia, and spinal cord were examined. Results: Positive immunostaining of the myenteric plexus was detected in significantly more achalasia and GORD samples than control samples (achalasia, p<0.001; GORD, p<0.01), and immunoreactivity was significantly more intense with achalasia and GORD serum samples than controls (achalasia, p<0.01; GORD, p<0.05). There was no correlation between intensity of immunoreactivity and duration of achalasia symptoms. In most cases, achalasia and GORD sera stained all ileal submucosal and myenteric neurones, and oesophageal neurones. Immunostaining was not species specific; however, immunostaining was largely specific for enteric neurones. Western blot analysis failed to reveal specific myenteric neuronal proteins that were labelled by antibodies in achalasia or GORD serum. Conclusions: These data suggest that antineuronal antibodies ore generated in response to tissue damage or some other secondary phenomenon in achalasia and GORD. We conclude that antineuronal antibodies found in the serum of patients with achalasia represent an epiphenomenon and not a causative factor.
ACCESSION #
9737010

 

Related Articles

  • Gastroesophageal Reflux in Children: When to be Concerned. Chitkara, Denesh; Martin, Nannette; Kelly, Maureen // Pediatrics for Parents;2006, Vol. 22 Issue 8, p7 

    The article talks about gastroesophageal reflux, the passage of stomach contents into the esophagus, which is a common problem in infants and children that typically occurs during or after a meal in 50 percent of newborns and up 67 percent of four month-old infants. The frequent episodes of...

  • Laparoscopic Esophagomyotomy for Achalasia Without a Complementary Antireflux Procedure. Diamantis, Theodoros; Pikoulis, Emmanouil; Felekouras, Evangelos; Tsigris, Christos; Arvelakis, Antonios; Karavokyros, Ioannis; Bastounis, Elias // Journal of Laparoendoscopic & Advanced Surgical Techniques;Aug2006, Vol. 16 Issue 4, p345 

    Background: Achalasia is a progressive motility disorder of the esophagus, without a definitive cure. The principal method of palliation is myotomy of the distal esophagus. We analyzed the 5-year experience at our institution with laparoscopic Heller myotomy without an antireflux procedure to...

  • A Prospective Assessment of Gastroesophageal Reflux before and after Treatment of Achalasia Patients: Pneumatic Dilation Versus Transthoracic Limited Myotomy. Shoenut, J. Patrick; Duerksen, Donald; Yaffe, Clifford S. // American Journal of Gastroenterology;Jul1997, Vol. 92 Issue 7, p1109 

    Objectives: We conducted this study to determine whether reflux should be a major consideration in the choice of treatment for achalasia patients. Achalasia patients undergoing either pneumatic dilation or transthoracic limited esophagomyotomy were monitored for reflux before and after...

  • Endoscopy for GORD, dyspepsia.  // New Zealand Doctor;8/24/2011, p44 

    The article discusses the different aspects of the use of endoscopy in determining dyspepsia as well as gastro-oesophageal reflux disease (GORD). It mentions that this medical diagnosis method may give low yield in terms of the organic causes of the symptoms. The author adds that oesophageal...

  • Common Questions About the Management of Gastroesophageal Reflux Disease. ANDERSON III, WILLIAM D.; STRAYER, SCOTT M.; MULL, SHANE R. // American Family Physician;5/15/2015, Vol. 91 Issue 10, p692 

    Common questions that arise regarding treatment of gastroesophageal reflux disease (GERD) include which medications are most effective, when surgery may be indicated, which patients should be screened for Barrett esophagus and Helicobacter pylori infection, and which adverse effects occur with...

  • Results of Short- and Long-Segment Cardioesophageal Myotomy for Achalasia. Aghajanzadeh, Manouchehr; Moghadam, Anoush D.; Hemmati, Hosein; Aghajanzadeh, Gilda; Massahnia, Sara // Saudi Journal of Gastroenterology;Jul/Aug2012, Vol. 18 Issue 4, p237 

    Background/Aim: We report the results of a short- and long-segment cardiomyotomy for relief of the symptoms of achalasia. Patients and Methods: From 1997 to 2009, 41 patients (22 men, 19 women) with achalasia underwent cardiomyotomy. Patients were divided into 2 groups [short-segment group (SSG)...

  • Pneumatic Dilation in Patients with Achalasia with a Modified Gruntzig Dilator (Levine) under Direct Endoscopic Control: Results after 5 Years. Levine, Milton L.; Moskowitz, Gerard W.; Dorf, Barry S.; Bank, Simmy // American Journal of Gastroenterology;Nov1991, Vol. 86 Issue 11, p1581 

    From 1985 to 1990, 62 patients have undergone pneumatic dilatation with the modified Gruntzig (Levine) dilator in the treatment of achalasia. A single dilatation with a 30-mm balloon dilator was successful in 85% of the patients. Nine patients required additional procedures. One elected for...

  • TREATMENT OF ACHALASIA. Hawthorne, Herbert R.; Frobese, A. S. // American Journal of Gastroenterology;Aug1961, Vol. 36 Issue 2, p143 

    Presents information on the treatment of achalasia of the esophagus, a result of a disturbance of peristalsis. Primary site of derangement in esophagus; Percentage of patients who do not respond to medical treatment; Effect of pyloroplasty or subtotal gastrectomy on an existing esophagitis of...

  • The outcome of laparoscopic Heller myotomy without antireflex procedure in patients with achalasia. Wang, Peter C.; Sharp, Kenneth W.; Holzman, Michael D.; Clements, Ronald H.; Holcomb, George W.; Richards, William O. // American Surgeon;Jun1998, Vol. 64 Issue 6, p515 

    Presents a retrospective review of patients with achalasia undergoing laparoscopic Heller myotomy without antireflux procedure to assess relief of dysphagia and prevalence of postoperative gastroesophageal reflux. Ranges of preoperative weight loss; Frequency of preoperative symptoms;...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics