Changing genes; losing lactase
- Q&A. // Health & Fitness Magazine;Aug2014, p30
The article presents an answer to a question about lactose intolerance.
- Lactase Persistence and Bitter Taste Response: Instrumental Variables and Mendelian Randomization in Epidemiologic Studies of Dietary Factors and Cancer Risk. Carlotta Sacerdote; Simonetta Guarrera; George Davey Smith; Sara Grioni; Vittorio Krogh; Giovanna Masala; Amalia Mattiello; Domenico Palli; Salvatore Panico; Rosario Tumino; Fabrizio Veglia; Giuseppe Matullo; Paolo Vineis // American Journal of Epidemiology;Aug2007, Vol. 166 Issue 5, p576
Consumption of dairy products seems to increase the risk of cancer at several sites, while intake of cruciferous vegetables could have protective effects. However, these dietary intakes are subject to measurement error, and associations with cancer could be due to confounders. Mendelian...
- Pass the Milk Gene. A. B. // Natural History;Mar2014, Vol. 122 Issue 2, p8
The article discusses the condition of lactase persistence, a genetic mutation that allows various human populations to digest milk as adults as of March 2014, with information on a study led by molecular anthropologist Christina Warinner on the history of lactase persistence in Europe.
- High prevalence of lactase non-persistence among indigenous nomadic Nenets, north-west Russia. Khabarova, Yulia; Grigoryeva, Valentina; Tuomisto, Sari; Karhunen, Pekka J.; Mattila, Kari; Isokoski, Mauri // International Journal of Circumpolar Health;2012, Vol. 71, p1
Objectives. The frequency of adult-type hypolactasia (lactase non-persistence) varies widely among different ethnic groups. The cultural historical hypothesis assumes a link between the occurrence of hypolactasia and the distribution of dairy farming. The nomadic Nenets have been reindeer...
- Hunting for the LCT-13910*T Allele between the Middle Neolithic and the Middle Ages Suggests Its Absence in Dairying LBK People Entering the Kuyavia Region in the 8th Millennium BP. Witas, Henryk W.; Płoszaj, Tomasz; Jędrychowska-Dańska, Krystyna; Witas, Piotr J.; Masłowska, Alicja; Jerszyńska, Blandyna; Kozłowski, Tomasz; Osipowicz, Grzegorz // PLoS ONE;Apr2015, Vol. 10 Issue 4, p1
Populations from two medieval sites in Central Poland, Stary BrzeÅ›Ä‡ Kujawski-4 (SBK-4) and Gruczno, represented high level of lactase persistence (LP) as followed by the LCT-13910*T alleleâ€™s presence (0.86 and 0.82, respectively). It was twice as high as in contemporaneous Cedynia...
- Latitude, sunshine, and human lactase phenotype distributions may contribute to geographic patterns of modern disease: the inflammatory bowel disease model. Szilagyi, Andrew; Leighton, Henry; Burstein, Barry; Xiaoqing Xue // Clinical Epidemiology;2014, Vol. 6, p183
Countries with high lactase nonpersistence (LNP) or low lactase persistence (LP) populations have lower rates of some "western" diseases, mimicking the effects of sunshine and latitude. Inflammatory bowel disease (IBD), ie, Crohn's disease and ulcerative colitis, is putatively also influenced by...
- Lactase persistence may have an independent origin in Tibetan populations from Tibet, China. Peng, Min-Sheng; He, Jun-Dong; Zhu, Chun-Ling; Wu, Shi-Fang; Jin, Jie-Qiong; Zhang, Ya-Ping // Journal of Human Genetics;Jun2012, Vol. 57 Issue 6, p394
Milk consumption is prevalent in daily diets of Tibetans. To digest the milk sugar lactose, lactase persistence (LP) should be required. However, little is known about the genetic basis of LP in Tibetans. We screened 495 Tibetan individuals for five previously reported single-nucleotide...
- Evolutionary Genetics: Genetics of lactase persistence-fresh lessons in the history of milk drinking. Hollox, Edward // European Journal of Human Genetics;Mar2005, Vol. 13 Issue 3, p267
Focuses on the genetic aspects of lactase persistence. Characteristics of the gene controlling lactase persistence/nonpersistence; Correlation between lactase persistence and the dairying history of the population; Location of the causative polymorphism inducing lactase nonpersistence.
- The Origins of Lactase Persistence in Europe. Itan, Yuval; Powell, Adam; Beaumont, Mark A.; Burger, Joachim; Thomas, Mark G. // PLoS Computational Biology;Aug2009, Vol. 5 Issue 8, p1
Lactase persistence (LP) is common among people of European ancestry, but with the exception of some African, Middle Eastern and southern Asian groups, is rare or absent elsewhere in the world. Lactase gene haplotype conservation around a polymorphism strongly associated with LP in Europeans...