TITLE

Evaluation of Anti-Cancer Activity and Anti-Oxidant Status of Calocybe Indica (Milky Mushroom) On Dalton's Lymphoma Ascites Induced Mice

AUTHOR(S)
Ganapathy, Jawahar; Renitta, Emilin
PUB. DATE
July 2014
SOURCE
Australian Journal of Basic & Applied Sciences;Jul2014, Vol. 8 Issue 10, p465
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The background of the present study is to evaluate the anti-cancer and anti-oxidant activity of Calocybe indica (C.indica) against Dalton's lymphoma ascites (DLA) induced mice. Intraperitoneal administration of C. indica (250 mg/kg body weight) to DLA bearing mice showed significant changes in the body weight, hematological parameters, peritoneal ascites fluid, anti-oxidant status and lipid peroxidation in serum and liver tissue samples of the Swiss albino mice. Histopathological examinations of the liver tissue from the Swiss albino mice were analyzed. GC-MS (Gas Chromatography Mass Spectrography) analysis of C. Indica was tested for volatile compounds to support the C. indica possess anti-cancer and antioxidant activities. Objective: To evaluate the anti-cancer and anti-oxidant activity of Calocybe indica (C.indica) against Dalton's lymphoma ascites (DLA) induced Swiss albino mice. Results: The result reveals that, there is a significant increase in hematological parameters such as RBC count, hemoglobin and significant decrease in WBC counts in C. indica treated mice. The anti-oxidant status was measured on serum and liver tissue samples of the Swiss albino mice. The C. indica administration exhibits anticancer activity by modulating lipid peroxidation and reversed the histopathological changes in cancer bearing mice. GC-MS analysis of C. indica showed the evidences of phytochemicals such as o-Toluidine, 2,4-Xylidine, 3-Dodecene (Z), 2,6-Xylidine , Benzyaldehyde 1-formylbenzo[b] Fluoranthene, anisaldehyde and benzaldehyde might possess the anticancer activity of C.indica. Conclusion:The present study suggests that C. indica possess anti-cancer and anti-oxidant activities and could be developed as an edible and potential (natural) anti-cancer agent.
ACCESSION #
97368514

 

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