Oxidative Stress and Lipid Profile Alterations in Albino Rat Liver Fed on Microwave Exposed Food

Hassani, Mohammed; Galal, Mona Kh.; El-Hindi, Hatem M. A.; Abdel-Aziz, Samy A.
June 2014
Australian Journal of Basic & Applied Sciences;Jun2014, Vol. 8 Issue 9, p412
Academic Journal
Background: the health consideration of microwave (MW) radiation has been the subject of scientific investigations particularly in the last decades. There is a little information about the adverse effect of consumption of MW treated food. Objective: this study was designed to find out the effect of continuous intake of MW exposed food on diet composition, lipid peroxidation (LPO), antioxidant enzymes, DNA fragmentation and the lipid profile in liver of albino rats. For this purpose, the rats were fed for 15 weeks on a fixed amount of food exposed to the MW radiation for 10 minutes at 320°C in MW oven. Blood and tissue samples were collected after 3, 6, 9, 12 and 15 weeks. Results: According to our results, MW treatment changed the diet composition. Data showed a significant depletion in reduced glutathione all over the experimental period and elevation in of LPO after 6, 12 and 15 weeks, which sign of oxidative stress. Moreover a significant increase in fragmentation after 9 weeks was detected. A significant increase total cholesterol and LDL-C level and reduction in HDL-C were observed. Conclusion: Feeding of rats on MW exposed food induced hepatotoxicity by increasing LPO and alteration of lipid metabolism particularly in lipoproteins metabolism.


Related Articles

  • Salinity Induced Changes in Oxidative Stress and Antioxidant Status as Affected by Applications of Silicon in Lettuce (Lactuca sativa). MILNE, CHRISTOPHER J.; LAUBSCHER, CHARLES P.; NDAKIDEMI, PATRICK A.; MARNEWICK, JEANINE L.; RAUTENBACH, FANIE // International Journal of Agriculture & Biology;2012, Vol. 14 Issue 5, p83 

    The antioxidant content, capacity and certain oxidative stress parameters were investigated in salinity stressed Lactuca sativa L. 'Eish!' with the addition of exogenous silicon (Si). No significant changes were shown for total polyphenol concentrations in any of the experimental plants....

  • Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by Withania somnifera Leaf Extract. Khalil, Md. Ibrahim; Ahmmed, Istiyak; Ahmed, Romana; Tanvir, E. M.; Afroz, Rizwana; Paul, Sudip; Gan, Siew Hua; Alam, Nadia // BioMed Research International;10/11/2015, Vol. 2015, p1 

    We investigated the protective role of Withania somnifera leaf extract (WSLEt) on isoproterenol- (ISO-) induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (85 mg/kg body weight (b.w.)) administered to rats for two consecutive days caused a significant increase in...

  • Selenium Reduces Oxidative Stress and Calcium Entry Through TRPV1 Channels in the Neutrophils of Patients with Polycystic Ovary Syndrome. Köse, Seyit; Nazıroğlu, Mustafa // Biological Trace Element Research;May2014, Vol. 158 Issue 2, p136 

    Polycystic ovary syndrome (PCOS) is a common inflammatory disease with an uncertain pathogenesis, although one consistent finding is increased neutrophil activity. It has been recently reported that the essential antioxidant element selenium has protective effects on oxidative stress and...

  • Nicotine Alters Serum Antioxidant Profile in Male Albino Rats. Oyeyipo, Ibukun Peter; Raji, Yinusa; Bolarinwa, Adeyombo Folashade // North American Journal of Medical Sciences;Apr2014, Vol. 6 Issue 4, p168 

    Background: Oxidative stress has repeatedly been implicated as the leading cause of several disease conditions. Aim: This study was designed to investigate the effects of nicotine administration on serum antioxidant levels in male albino rats. Materials and Methods: Forty male rats (150-180 g)...

  • Acute effects of fenthion on certain oxidative stress biomarkers in various tissues of frogs (Rana ridibunda). Kanter, Ahmet; Celik, Ismail // Toxicology & Industrial Health;May2012, Vol. 28 Issue 4, p369 

    This study was aimed mainly to assess the effects of fenthion on certain oxidative stress biomarkers in various tissues of frogs (Rana ridibunda). Biomarkers selected for stress monitoring were malondialdehyde (MDA) and antioxidant defense system (ADS) such as reduced glutathione (GSH) level,...

  • Protective effect of vanillin against carbon tetrachloride (CCl4)-induced oxidative brain injury in rats. Makni, Mohamed; Chtourou, Yassine; Barkallah, Mohamed; Fetoui, Hamadi // Toxicology & Industrial Health;Aug2012, Vol. 28 Issue 7, p655 

    This study investigated the protective effects of vanillin against acute brain damage induced by carbon tetrachloride (CCl4) in rats. The study was performed on 32 male rats divided into four groups: a control group, vanillin group ([Va] 150 mg/kg/day, intraperitoneally [i.p.]) and CCl4...

  • Effect of Carissa opaca leaves extract on lipid peroxidation, antioxidant activity and reproductive hormones in male rats. Sahreen, Sumaira; Khan, Muhammad Rashid; Khan, Rahmat Ali; Shah, Naseer Ali // Lipids in Health & Disease;2013, Vol. 12 Issue 1, p1 

    Background: Carissa opaca leaves are traditionally used in the treatment of male dysfunction and hormonal disorder as well as in oxidative stress in Pakistan and Asia. The present study was designed to assess the protective effects of methanolic extract of Carissa opaca leaves (MLC) on carbon...

  • Evaluation of endothelial adaptation and parameters of oxidative stress in patients after hemodialysis sessions. Prá, Valéria Dal; Bisol, Lais Biazus; Paraboni, Marisa L. Romani; de Oliveira Siqueira, Luciano // Journal of Applied Pharmaceutical Science;Oct2013, Vol. 3 Issue 10, p39 

    This work was focused on the evaluation of parameters of oxidative stress (lipid peroxidation, total thiol groups, non-protein thiol groups, polyphenols and ascorbate) and endothelial adaptation by determining the nitric oxide (NO), high-sensitive C-reactive protein (HS-CRP) and...

  • The protective effects of carnosine in alcohol-induced hepatic injury in rats. Baykara, B; Mıcılı, S Cilaker; Tugyan, K; Tekmen, I; Bagriyanik, HA; Sonmez, U; Sonmez, A; Oktay, G; Yener, N; Ozbal, S // Toxicology & Industrial Health;Feb2014, Vol. 30 Issue 1, p25 

    Consumption of alcohol leads to oxidative stress in liver by inducing lipid peroxidation. The aim of this study was to investigate the effects of carnosine (CAR) in alcohol-induced liver injury by biochemical and histomorphological evaluations. The rats were divided into four groups, namely,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics