TITLE

BIOMOTRICITY ROUNDTABLE--GENÔMICA E FISIOLOGIA MOLECULAR DO EXERCÍCIO E DO ESPORTE

AUTHOR(S)
Katayama Yamada, André; Bertuzzi, Rômulo; Costa Leite, Tiago; Prestes, Jonato; Bueno Junior, Carlos Roberto
PUB. DATE
December 2013
SOURCE
Brazilian Journal of Biomotricity;2013, Vol. 7 Issue 4, p182
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Biomotricity roundtable - genômica e fisiologia molecular do exercício e do esporte. Brazilian Journal of Biomotricity. v. 7, n. 4, p. 182-207, 2013. The objective of the roundtable was to discuss the topic Genomic and Molecular Exercise Physiology, an emergent and recent field in exercise physiology. For the discussion of this scientific scenario, 10 specialists were invited, where among them four responded to the request. Eight questions about genetics and molecular biology were prepared about genetics and molecular biology applied to physical exercise and sports. After answering the questions researchers received the answers of the other participants in a blind system for the rebuttal. Based on the discussion it can be concluded that: 1) the candidate genes and variants that modulate physical performance has been mapped, and the molecular tools are now capable to monitor tissue adaptations in response to exercise. 2) Animal models allow more invasive genetic and pharmacological manipulations and rigorous control of experimental conditions, while there are differences as compared with human physiology. 3) The discovery of candidate genes involved in human performance and studies with gene therapy allowed the possibility to develop gene doping. 4) Studies in vitro allow the manipulation of target proteins or inhibition by drugs in a well-controlled environment, however this model presents limitations as it unable the access of the organism. 5) The detection of talents by genotyping is a promising approach but faces ethic issues. 6) Molecular biology allows the understanding of the mechanisms responsible for phenotypic adaptations, which was exclusively studied at physiological level. Additionally, analysis of whole proteins (proteome) and genes (genome), along with RNAi and miRNA studies are under course. 7) Currently genetics does not allow a direct application in physical education, although this will soon be possible. 8) The future of molecular biology and genomics will focus on epigenetic mechanisms and interactions between genes and environment. In conclusion, genomic and molecular biology will be valuable tools for exercise physiology, as they will allow the understanding of the effects of exercise at a more complex level, which will enhance professional conduct.
ACCESSION #
97326258

 

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