Katayama Yamada, André; Bertuzzi, Rômulo; Costa Leite, Tiago; Prestes, Jonato; Bueno Junior, Carlos Roberto
December 2013
Brazilian Journal of Biomotricity;2013, Vol. 7 Issue 4, p182
Academic Journal
Biomotricity roundtable - genômica e fisiologia molecular do exercício e do esporte. Brazilian Journal of Biomotricity. v. 7, n. 4, p. 182-207, 2013. The objective of the roundtable was to discuss the topic Genomic and Molecular Exercise Physiology, an emergent and recent field in exercise physiology. For the discussion of this scientific scenario, 10 specialists were invited, where among them four responded to the request. Eight questions about genetics and molecular biology were prepared about genetics and molecular biology applied to physical exercise and sports. After answering the questions researchers received the answers of the other participants in a blind system for the rebuttal. Based on the discussion it can be concluded that: 1) the candidate genes and variants that modulate physical performance has been mapped, and the molecular tools are now capable to monitor tissue adaptations in response to exercise. 2) Animal models allow more invasive genetic and pharmacological manipulations and rigorous control of experimental conditions, while there are differences as compared with human physiology. 3) The discovery of candidate genes involved in human performance and studies with gene therapy allowed the possibility to develop gene doping. 4) Studies in vitro allow the manipulation of target proteins or inhibition by drugs in a well-controlled environment, however this model presents limitations as it unable the access of the organism. 5) The detection of talents by genotyping is a promising approach but faces ethic issues. 6) Molecular biology allows the understanding of the mechanisms responsible for phenotypic adaptations, which was exclusively studied at physiological level. Additionally, analysis of whole proteins (proteome) and genes (genome), along with RNAi and miRNA studies are under course. 7) Currently genetics does not allow a direct application in physical education, although this will soon be possible. 8) The future of molecular biology and genomics will focus on epigenetic mechanisms and interactions between genes and environment. In conclusion, genomic and molecular biology will be valuable tools for exercise physiology, as they will allow the understanding of the effects of exercise at a more complex level, which will enhance professional conduct.


Related Articles

  • Editor's Comments. Gregor, Robert J. // Journal of Applied Biomechanics;Feb1993, Vol. 9 Issue 1, p1 

    This article reports on the expansion of the traditional field of sports biomechanics. According to the author, the field of sports biomechanics can no longer afford to simply describe movement outcomes. Mandated by the need to identify mechanisms that control movement, minimize trauma, and...

  • Book review.  // Applied Physiology, Nutrition & Metabolism;Aug2013, Vol. 38 Issue 8, p911 

    The article reviews the book "Biophysical Foundations of Human Movement," third edition, edited by B. Abernethy, V. Kippers, S. J. Hanrahan, M. G. Pandy, A. M. McManus and L. Mackinnon.

  • An empirical assessment of validation practices for molecular classifiers. Castaldi, Peter J.; Dahabreh, Issa J.; Ioannidis, John P.A. // Briefings in Bioinformatics;May2011, Vol. 12 Issue 3, p189 

    Proposed molecular classifiers may be overfit to idiosyncrasies of noisy genomic and proteomic data. Cross-validation methods are often used to obtain estimates of classification accuracy, but both simulations and case studies suggest that, when inappropriate methods are used, bias may ensue....

  • AbsIDconvert: An absolute approach for converting genetic identifiers at different granularities. Mohammad, Fahim; Flight, Robert M.; Harrison, Benjamin J.; Petruska, Jeffrey C.; Rouchka, Eric C. // BMC Bioinformatics;2012, Vol. 13 Issue 1, p229 

    Background: High-throughput molecular biology techniques yield vast amounts of data, often by detecting small portions of ribonucleotides corresponding to specific identifiers. Existing bioinformatic methodologies categorize and compare these elements using inferred descriptive annotation given...

  • Universal platform for quantitative analysis of DNA transposition. Pajunen, Maria I.; Rasila, Tiina S.; Happonen, Lotta J.; Lamberg, Arja; Haapa-Paananen, Saija; Kiljunen, Saija; Savilahti, Harri // Mobile DNA;2010, Vol. 1 Issue 1, p1 

    Background: Completed genome projects have revealed an astonishing diversity of transposable genetic elements, implying the existence of novel element families yet to be discovered from diverse life forms. Concurrently, several better understood transposon systems have been exploited as...

  • KINE 30623: BIOMECHANICS.  // TCU Magazine;Winter2019, Vol. 63 Issue 1, p18 

    No abstract available.

  • UvrD helicase, unlike Rep helicase, dismantles RecA nucleoprotein filaments in Escherichia coli. Veaute, Xavier; Delmas, Stéphane; Selva, Marjorie; Jeusset, Josette; Le Cam, Eric; Matic, Ivan; Fabre, Francis; Petit, Marie-Agnès // EMBO Journal;1/12/2005, Vol. 24 Issue 1, p180 

    The roles of UvrD and Rep DNA helicases of Escherichia coli are not yet fully understood. In particular, the reason for rep uvrD double mutant lethality remains obscure. We reported earlier that mutations in recF, recO or recR genes suppress the lethality of uvrD rep, and proposed that an...

  • Back to the biology in systems biology: What can we learn from biomolecular networks? Sui Huang // Briefings in Functional Genomics & Proteomics;Feb2004, Vol. 2 Issue 4, p279 

    Genome-scale molecular networks, including protein interaction and gene regulatory networks, have taken centre stage in the investigation of the burgeoning disciplines of systems biology and biocomplexity. What do networks tell us? Some see in networks simply the comprehensive, detailed...

  • ORFeomics: correcting the wiggle in worm genes. Boone, Charles; Andrews, Brenda // Nature Genetics;May2003, Vol. 34 Issue 1, p8 

    A new study attempts to amplify and clone all the predicted protein-encoding open reading frames (ORFs) for Caenorhabditis elegans. This analysis confirms many of the predicted genes but suggests roughly 504570360f them require correction. Recombining the ORFs into a number of different...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics