Serum pepsinogen concentration as a marker of Helicobacter pylori infection and the histologic grade of gastritis; evaluation of gastric mucosa by serum pepsinogen levels

Kiyohira, Kuninushi; Yoshihara, Masaharu; Ito, Masanori; Haruma, Ken; Tanaka, Shinji; Chayama, Kazuaki
April 2003
Journal of Gastroenterology;2003, Vol. 38 Issue 4, p332
Academic Journal
Background. Helicobacter pylori infection and associated gastritis are well-known significant factors in many gastrointestinal diseases, and evaluation of these conditions is important for health evaluation. We investigated the utility of serum pepsinogen (PG) concentrations for the diagnosis of H. pylori infection and evaluation of the grade of histologic gastritis. Methods. The subjects consisted of 283 individuals (147 men and 136 women; mean age, 44.0 years). Biopsy specimens were obtained from the gastric antrum and body to assess grade of inflammation and atrophy and histologic evidence of H. pylori infection. H. pylori infection was judged by Giemsa staining and serum IgG antibodies against H. pylori. PG concentrations were determined by radioimmunoassay. Results. In subjects with H. pylori infection, serum PGII concentrations were increased, and the PGI/PGII ratio (I/II ratio) was decreased. In patients with marked atrophy or intestinal metaplasia, both serum PGI and the I/II ratio were decreased. When PGII concentrations of 12ng/ml or more, or a I/II ratio of 4.0 or less were used as the cutoff points for the diagnosis of H. pylori infection, the sensitivity and specificity of diagnosis were 90.0% and 93.5%, respectively. All subjects with serum PGI concentrations of 85 or more ng/ml, or serum PGII concentrations of 15 or more ng/ml were H. pylori-positive and all subjects with a I/II ratio of more than 6.5 were H. pylori-negative. Conclusions. These results suggest that H. pylori infection, gastritis, and glandular atrophy of the stomach can be evaluated via serum PG concentrations, allowing the evaluation of gastric mucosal integrity.


Related Articles

  • Associated Factors of Atrophic Gastritis Diagnosed by Double-Contrast Upper Gastrointestinal Barium X-Ray Radiography: A Cross-Sectional Study Analyzing 6,901 Healthy Subjects in Japan. Yamamichi, Nobutake; Hirano, Chigaya; Shimamoto, Takeshi; Minatsuki, Chihiro; Takahashi, Yu; Nakayama, Chiemi; Matsuda, Rie; Fujishiro, Mitsuhiro; Konno-Shimizu, Maki; Kato, Jun; Kodashima, Shinya; Ono, Satoshi; Niimi, Keiko; Mochizuki, Satoshi; Tsuji, Yosuke; Sakaguchi, Yoshiki; Asada-Hirayama, Itsuko; Takeuchi, Chihiro; Yakabi, Seiichi; Kakimoto, Hikaru // PLoS ONE;Oct2014, Vol. 9 Issue 10, p1 

    Background: Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) is one of the most widely conducted gastric cancer screening methods. It has been executed to find gastric cancer, but has not been usually executed to detect premalignant atrophic mucosa of stomach. To...

  • Serological Markers for Gastric Atrophy in Asymptomatic Patients Infected withHelicobacter pylori. Ricci, Chiara; Vakil, Nimish; Rugge, Massimo; Gatta, Luigi; Perna, Federico; Osborn, John F.; Russo, Valentina M.; Tampieri, Andrea; Bernabucci, Veronica; Miglioli, Mario; Vaira, Dino // American Journal of Gastroenterology;Oct2004, Vol. 99 Issue 10, p1910 

    OBJECTIVE: Atrophic gastritis is a precancerous condition that is commonly caused by chronicHelicobacter pylori(H. pylori) infection. This blinded, controlled study was designed to determine if serum gastrin and pepsinogens were reliable markers of atrophy in asymptomatic patients.METHODS: One...

  • Relationship between direct and indirect methods for diagnosis of H. pylori infection. Moussa, A.M.; Iori, V.; Aragona, G.; Seghini, P.; Cerati, E.; Campi, L.; Cavestro, G.M.; Comparato, G.; Leandro, G.; Battaglia, G.; Dal Bò, N.; Franzè, A.; Di Mario, F. // Gut;Sep2002 Supplement 2, Vol. 51, pA110 

    Background: Helicobacter pylori stool antigen test (HpSA) is a usefull,non-invasive tool for diagnosis and for the check of the eradication after therapy, in Helicobacter pylori (Hp) infection. Serum pepsinogen II (sPGII) levels were found increased during Hp infection mostly due to the antrum....

  • X-ray diagnosis of H pylori may be possible.  // Modern Medicine;Jul95, Vol. 63 Issue 7, p49 

    Presents an abstract of the article titled `Can the radiologist recognize Helicobacter pylori gastritis?' by D.J. Mond, R. Pochaczevsky, F. Vernace et al originally published in the April 1995 issue of the `Journal of Clinical Gastroenterology.'

  • H pylori gastritis: Noninvasive assays may be superior to biopsy gold standard.  // Modern Medicine;Aug96, Vol. 64 Issue 8, p45 

    Presents an abstract of a research titled `New Noninvasive Tests for Helicobacter pylori Gastritis: Comparison With Tissue-Based Gold Standard,' by D.O. Faigel, M. Childs, E.E. Furth, et al, published in the April 1996 issue of `Digestive Diseases Science.'

  • Kyoto global consensus report on Helicobacter pylori gastritis. Sugano, Kentaro; Tack, Jan; Kuipers, Ernst J.; Graham, David Y.; El-Omar, Emad M.; Soichiro Miura; Ken Haruma; Masahiro Asaka; Naomi Uemura; Malfertheiner, Peter // Gut;Sep2015, Vol. 64 Issue 9, p1353 

    Objective To present results of the Kyoto Global Consensus Meeting, which was convened to develop global consensus on (1) classification of chronic gastritis and duodenitis, (2) clinical distinction of dyspepsia caused by Helicobacter pylori from functional dyspepsia, (3) appropriate diagnostic...

  • Serum pepsinogen and Helicobacter pylori infection-a Japanese population study. Toyoda, K.; Furusyo, N.; Ihara, T.; Ikezaki, H.; Urita, Y.; Hayashi, J. // European Journal of Clinical Microbiology & Infectious Diseases;Sep2012, Vol. 31 Issue 9, p2117 

    The decreased ratio of serum pepsinogen (PG) I and II has good correlation with the presence of atrophic gastritis. A total of 1,540 residents aged 30-89 years were enrolled into this study to investigate which serum PG level of residents with Helicobacter pylori infection would represent an...

  • X-ray diagnosis of H pylori infection may be possible.  // Geriatrics;Jul95, Vol. 50 Issue 7, p56 

    Presents an abstract of the article `Can the Radiologist Recognize Helicobacter pylori gastritis?,' by D.J. Mond, R. Pochaczevsky, et al published in the periodical `Journal of Clinical Gastroenterology,' in 1995, issue 20.

  • Helicobacter pylori water soluble surface proteins prime human neutrophils for enhanced production of reactive oxygen species and stimulate chemokine production. Shimoyama, T.; Fukuda, S.; Liu, Q.; Nakaji, S.; Fukuda, Y.; Sugawara, K. // Journal of Clinical Pathology;May2003, Vol. 56 Issue 5, p348 

    Backgrounds/Aims: Chronic gastritis induced by Helicobacter pylori is characterised by considerable neutrophil infiltration into the gastric mucosa without mucosal invasion of bacteria. Bacteria have different characteristics with respect to their ability to stimulate human neutrophils to...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics