Assessemnt of nasal bone in first trimester screening for chromosomal abnormalities in Khuzestan

Masihi, Sara; Barati, Mojgan; Mohamadjafari, Razieh; Hashemi, Marzieh
May 2014
Iranian Journal of Reproductive Medicine;May2014, Vol. 12 Issue 5, p321
Academic Journal
Background: Fetal nasal bone assessment is a non-invasive procedure that helps provide even greater assurance to patients undergoing their first trimester risk assessment for aneuploidies. Absence or presence of this factor is different in some races. Objective: The study was aimed to evaluate nasal bone in the first trimester of pregnancy in the indigenous population of Khuzestan Province, and to monitor its value in the diagnosis of chromosomal abnormalities. Materials and Methods: This study was conducted on 2314 pregnant women between 17-43 years old who referred for first trimester screening for chromosomal abnormalities. Gestational age was between 11-13w + 6 days. Nuchal translucency (NT), fetal heart rate (FHR), crown rump length (CRL), and maternal age and maternal blood serum factors (Free (11 ICG) and pregnancy-associated plasma protein-A (PAPP-A) and nasal bone were assessed. Finally the risk of trisomies was calculated. The statistical tests are based on the relationship between chromosomal abnormality and the presence or absence of the nasal bone. Results: In 114 cases we could not examine the nasal bone. Also, in 20 cases missed abortion happened without knowing the karyotype. 2173 cases were delivered normal baby, and in seven cases chromosomal abnormalities were diagnosed. Nasal bone was absent in all three cases with trisomy 21 and six of 2173 cases with normal phenotype (0.3%). With use of the Fisher exact test (p=0.0001), a significant correlation was found between the absence of the nasal bone and the risk of chromosomal abnormality. Conclusion: Inclusion of the nasal bone in first-trimester combined screening for aneuploidies achieves greater detection rate especially in Down syndrome.


Related Articles

  • First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population. Teixeira, Cláudia; Tejera, Eduardo; Martins, Helena; Pereira, António Tomé; Costa-Pereira, Altamiro; Rebelo, Irene // Obstetrics & Gynecology International;2014, p1 

    Objective. To evaluate the performance of a first trimester aneuploidy screening program for preeclampsia (PE) prediction in a Portuguese obstetric population, when performed under routine clinical conditions. Materials and Methods. Retrospective cohort study of 5672 pregnant women who underwent...

  • Putting the FASTER results into clinical practice. D'Alton, Mary; Cleary-Goldman, Jane // Contemporary OB/GYN;Jan2006, Vol. 51 Issue 1, p54 

    This article discusses the importance of a first-trimester screening with fetal nuchal translucency for testing Down syndrome. It cites the possible outcomes of a First and Second Trimester Evaluation of Risk assessment in pregnancies. It also provides a perspective on the clinical significance...

  • EARLY NOTICE. Springen, Karen // Newsweek;7/12/2004, Vol. 144 Issue 2, p70 

    Looks at guidelines released by the American College of Obstetricians and Gynecologists for a first-trimester screening test that's becoming widely available to pregnant women. How the test works; Where to find more information.

  • Ultrasound evaluation of the fetal nasal bone: what is the most appropriate first-trimester cut-off point for aneuploidy screening? Mazzoni, Gui; Cabral, Antônio; Lima Faria, Marcos; Castro, Mário; Carvalho Pires, Magda; Johnson, David; Pettersen, Heverton // Archives of Gynecology & Obstetrics;May2012, Vol. 285 Issue 5, p1263 

    Purpose: To establish fetal nasal bone length cut-off points for first trimester aneuploidy screening based on a normal curve of a Brazilian population. Methods: The following tests were proposed: presence or absence of the nasal bone (NB); 2.5 and 5.0 NB percentiles relative to the normal...

  • First Trimester Ultrasound Screening: An Update. Sonek, J. D.; Glover, M.; Zhou, M.; Nicolaides, K. H. // Donald School Journal of Ultrasound in Obstetrics & Gynecology;Apr-Jun2010, Vol. 4 Issue 2, p97 

    For many years, the main use of ultrasound in the first trimester of pregnancy was to confirm viability and to establish gestational age. Indeed, the crown-rump length measurement in the first trimester remains the most accurate method to estimate the gestational age even today. However,...

  • Relationship between maternal thyroid hormones and the biochemical markers of the first trimester aneuploidy screening. Aytan, Hakan; Caliskan, Ahmet; Demirturk, Fazlı; Sahin, Semsettin; Erdogan, Filiz; Kuzu, Zehra // Archives of Gynecology & Obstetrics;Jun2013, Vol. 287 Issue 6, p1125 

    Purpose: The role of thyroid function in biochemical markers of first trimester screening has not been assessed. The aim of the present study was to investigate if there were any relation between maternal thyroid hormones and free-beta subunit of human chorionic gonadotropin (fβ-hCG) and...

  • First-Trimester Screening for Genetic Defects. Morantz, Carrie; Torrey, Brian // American Family Physician;10/15/2004, Vol. 70 Issue 8, p1592 

    Focuses on the report entitled "ACOG Committee Opinion No. 296: First-Trimester Screening for Fetal Aneuploidy," issued by the Committee on Genetics of the American College of Obstetricians and Gynecologists and appeared in the July 2004 issue of "Obstetrics and Gynecology" journal. Advantages...

  • Age-independent first trimester screening for Down syndrome: analysis of three modified software programs with 6,508 pregnancies. Hörmansdörfer, C.; Golatta, M.; Scharf, A.; Hillemanns, P.; Schmidt, P. // Archives of Gynecology & Obstetrics;Apr2011, Vol. 283 Issue 4, p749 

    Background: The conventional first trimester screening (FTS) method integrates maternal age into risk calculation. It was suggested that this concept increases the false-positive rate in older, and the false-negative rate in younger mothers. Materials and methods: Six thousand five hundred and...

  • Comparison of measured concentration values of biochemical serum markers with two immunoassay systems in first trimester screening for fetal aneuploidy. Hörmansdörfer, Cindy; Soergel, Philipp; Hillemanns, Peter; Schmidt, Peter // Archives of Gynecology & Obstetrics;Feb2012, Vol. 285 Issue 2, p553 

    Non-invasive first trimester screening for fetal aneuploidy is based on the consideration of fetal nuchal translucency, biochemical serum markers 'pregnancy associated plasma protein A' (PAPP-A), and 'free beta-humane chorionic gonadotropin' (fβ-hCG). The blood sera of 168 pregnant women in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics