FTIR, Electrochemical Impedance and Iontophoretic Delivery Analysis of Guar Gum and Sesame Oil Based Bigels

Singh, Vinay K.; Anis, Arfat; Al-Zahrani, S. M.; Pradhan, Dillip K.; Pal, Kunal
October 2014
International Journal of Electrochemical Science;2014, Vol. 9 Issue 10, p5640
Academic Journal
The objective of this study was to investigate the electrochemical properties of the prepared bigels and iontophoretic delivery of metronidazole for topical application. Bigels were prepared by mixing guar gum aquagel and Span 60-sesame oil based oleogel. FTIR spectra showed the formation of intermolecular hydrogen bonding. Impedance spectroscopy confirmed the conductive nature of bigels. The iontophoretic release study of metronidazole loaded bigels showed concentration dependent release of the drugs. The bigel containing higher concentrations of oleogel showed lower amount of drug release and followed zero order release kinetics. In conclusion, the results demonstrate that iontophoresis of metronidazole enables local enhanced topical delivery for treating various diseased conditions.


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