TITLE

FTIR, Electrochemical Impedance and Iontophoretic Delivery Analysis of Guar Gum and Sesame Oil Based Bigels

AUTHOR(S)
Singh, Vinay K.; Anis, Arfat; Al-Zahrani, S. M.; Pradhan, Dillip K.; Pal, Kunal
PUB. DATE
October 2014
SOURCE
International Journal of Electrochemical Science;2014, Vol. 9 Issue 10, p5640
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The objective of this study was to investigate the electrochemical properties of the prepared bigels and iontophoretic delivery of metronidazole for topical application. Bigels were prepared by mixing guar gum aquagel and Span 60-sesame oil based oleogel. FTIR spectra showed the formation of intermolecular hydrogen bonding. Impedance spectroscopy confirmed the conductive nature of bigels. The iontophoretic release study of metronidazole loaded bigels showed concentration dependent release of the drugs. The bigel containing higher concentrations of oleogel showed lower amount of drug release and followed zero order release kinetics. In conclusion, the results demonstrate that iontophoresis of metronidazole enables local enhanced topical delivery for treating various diseased conditions.
ACCESSION #
97184955

 

Related Articles

  • A high resolution infrared study of HCCCN–HCN and HCCCN–HF. Yang, X.; Kerstel, E. R. Th.; Scoles, G. // Journal of Chemical Physics;7/1/1993, Vol. 99 Issue 1, p760 

    The HCCCN–HCN and HCCCN–HF hydrogen bonded dimers have been investigated using optothermal techniques. Accurate molecular constants for both complexes are reported here and comparisons with similar complexes are made.

  • The NH and ND stretching fundamentals of 14ND[sub 2]H. Snels, Marcel; Hollenstein, Hans; Quack, Martin // Journal of Chemical Physics;10/15/2003, Vol. 119 Issue 15, p7893 

    High resolution (0.004 cm-1 instrumental bandwidth) interferometric Fourier transform infrared spectra of [sup 14]ND[sub 2]H were obtained on a BOMEM DA002 spectrometer under essentially Doppler limited conditions. We report the analysis of the ND and NH stretching fundamentals of [sup 14]ND[sub...

  • Rotational spectrum and structure of the linear CO2–HCN dimer: Dependence of isomer formation on carrier gas. Klots, T. D.; Ruoff, R. S.; Gutowsky, H. S. // Journal of Chemical Physics;4/15/1989, Vol. 90 Issue 8, p4216 

    A linear hydrogen-bonded dimer, OCO–HCN, has been identified and characterized via its microwave rotational spectrum. The study was made using the pulsed nozzle Fourier transform method with the Flygare/Balle Mark II spectrometer. A T-shaped HCN–CO2 dimer was reported earlier by...

  • FTIR spectroscopic studies and AM1 semi-empirical calculations of some hydrogen-bonded complexes of 2,5-dihydroxy-3,6-dichlorobenzoquinone and anilines. Habeeb, Moustafa M.; Gohar, Gamal A. // Spectroscopy: An International Journal;2003, Vol. 17 Issue 1, p65 

    Fourier transform infrared (FTIR) spectra of a series of 1 : 1 hydrogen-bonded complexes between 2,5-dihydroxy-3,6-dichlorobenzoquinone (chloranilic acid, CA) and anilines in the crystalline form were investigated. The correlation between the center of gravity of the protonic vibration bands (ν

  • Proton relay system in the active site of maltodextrinphosphorylase via hydrogen bonds with large proton polarizability: an FT-IR difference spectroscopy study. Bartl, F.; Palm, Dieter; Schinzel, Reinhard; Zundel, Georg // European Biophysics Journal;1999, Vol. 28 Issue 3, p200 

    Abstract Maltodextrinphosphorylase (MDP) was studied in the pH range 5.4-8.4 by Fourier transform infrared (FT-IR) spectroscopy. The pK[sub a] value of the cofactor pyridoxalphosphate (PLP) was found between 6.5 and 7.0, which closely resembles the second pK[sub a] of free PLP. FT-IR difference...

  • Coherent Raman and infrared spectroscopy of HCN complexes in free jet expansions and in equilibrium samples. Maroncelli, M.; Hopkins, G. A.; Nibler, J. W.; Dyke, T. R. // Journal of Chemical Physics;9/1/1985, Vol. 83 Issue 5, p2129 

    Small hydrogen bonded complexes of HCN and DCN have been examined in the gas phase using FTIR and photoacoustic Raman spectroscopy (PARS). Four distinct bands are seen and assigned to CN stretching modes of the HCN dimer (D) and trimer (T). Previous microwave studies have shown the HCN dimer to...

  • Infrared spectra of the very weak H2--HF and O2--HF complexes in solid neon. Hunt, Rodney D.; Andrews, Lester // Journal of Chemical Physics;4/1/1987, Vol. 86 Issue 7, p3781 

    Very weak, hydrogen bonded complexes of molecular hydrogen and oxygen with HF have been prepared by condensing the neon diluted reagents at 4–5 K. Infrared spectra of the H2--HF complex revealed a νs(HF) mode at 3938 cm-1 and νc(H2) mode at 4155 cm-1 which are red shifted from...

  • Artificial versus natural ageing of paper. Water role in degradation mechanisms. Łojewski, Tomasz; Miśkowiec, Paweł; Molenda, Marcin; Lubańska, Anna; Łojewska, Joanna // Applied Physics A: Materials Science & Processing;Aug2010, Vol. 100 Issue 3, p625 

    The cellulose–water system was traced down by the in situ transmission FTIR spectroscopy upon water desorption/sorption cycles at various conditions (dry air, humid air, water vapour) and temperatures. The results provide the information on the changes of the hydrogen bonds network during...

  • The competition between hydrogen bonding and chemical change in carbohydrate nanoparticles. Jetzki, Martin; Signorell, Ruth // Journal of Chemical Physics;11/1/2002, Vol. 117 Issue 17, p8063 

    Broad band Fourier transform infrared spectroscopy was used to study the competition between hydrogen bonding and conformational and chemical changes in molecular nanoparticles. Particles of small carbohydrates (dihydroxyacetone, glyceraldehyde, fructose, and glucose) with sizes between 20 and...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics