TITLE

TOXIC EFFECTS OF FLUORIDE ON PRIMARY LYMPHOID ORGANS AND WHITE BLOOD CELLS IN FEMALE MICE

AUTHOR(S)
Jing Zhao; Hongwei Wang; Tian, Erjie; Faming Dong; Bianhua Zhou
PUB. DATE
July 2014
SOURCE
Fluoride;Jul-Sep2014, Vol. 47 Issue 3, p227
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Our previous studies showed that excessive fluoride (F) induced thymus apoptosis in female rats. Here, we investigated the toxic effects of F on lymphocytes and the complete blood count in female mice. The results showed that excessive F reduced weight gain and induced ultrastructural changes and DNA damage in the immunocytes. Compared to the control group, in the F group, in the thymus, bone marrow, and blood lymphocytes, typical comet configurations were present and the ratio of tailing and the tail length of the immunocytes were significantly increased. Decreases occurred in the blood in the total white blood cell (WBC) count (p<0.01), lymphocytes (p<0.05), middle cells (p<0.05), granulocytes (p<0.05) and the thrombocytocrit (p<0.05). In conclusion, in female mice, excessive F reduces weight gain, seriously damages the DNA and ultrastructure of immunocytes, and reduces blood total WBC count, lymphocytes, middle cells, granulocytes, and the thrombocytocrit.
ACCESSION #
97168104

 

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