TITLE

Tumor suppressor TSLC1 inhibits growth, proliferation, invasiveness and angiogenesis in nude mice xenografted tumor of Eca109 cells

AUTHOR(S)
Qi-Lian Liang; Guo-Qiang Chen; Qiu-Long Liu; Zhou-Yu Li; Xiang-Ning Zhang; Yuan Zhou; Wen-Ting Ou; Bi-Rong Wang; Li-Ren Hu
PUB. DATE
July 2014
SOURCE
International Journal of Clinical & Experimental Medicine;2014, Vol. 7 Issue 6, p1507
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Tumor suppressor in lung cancer 1 (TSLC1) is a novel tumor suppressor gene whose inactivation is implicated in the occurrence, invasion, metastasis and prognosis of esophageal cancer. TSLC1 was studied by comparing the tumor formation of TSLC1 transfectant and control cells in nude mice. Compared with blank group and mock group, tumor size and infiltrating range of transfected group was less, differentiation of tumor tissue was slightly better, and differences of tumor angiogenesis was worse. There was no obvious difference between blank group and mock group. We have shown TSLC1 gene inhibited the growth proliferation, infiltration and angiogenesis of Eca109 cells.
ACCESSION #
97121001

 

Related Articles

  • Identification and expansion of the tumorigenic lung cancer stem cell population. Eramo, A.; Lotti, F.; Sette, G.; Pilozzi, E.; Biffoni, M.; Di Virgilio, A.; Conticello, C.; Ruco, L.; Peschle, C.; De Maria, R. // Cell Death & Differentiation;Mar2008, Vol. 15 Issue 3, p504 

    Lung carcinoma is often incurable and remains the leading cancer killer in both men and women. Recent evidence indicates that tumors contain a small population of cancer stem cells that are responsible for tumor maintenance and spreading. The identification of the tumorigenic population that...

  • Skin human papillomavirus type 38 alters p53 functions by accumulation of ?Np73. Accardi, Rosita; Wen Dong; Smet, Anouk; Cui, Rutao; Hautefeuille, Agnes; Gabet, Anne-Sophie; Sylla, Bakary S.; Gissmann, Lutz; Hainaut, Pierre; Tommasino, Massimo // EMBO Reports;Mar2006, Vol. 7 Issue 3, p334 

    The E6 and E7 of the cutaneous human papillomavirus (HPV) type 38 immortalize primary human keratinocytes, an event normally associated with the inactivation of pathways controlled by the tumour suppressor p53. Here, we show for the first time that HPV38 alters p53 functions. Expression of HPV38...

  • p53 in polyoma virus transformed REF52 cells. Mor, Orna; Read, Moira; Fried, Mike // Oncogene;12/18/97, Vol. 15 Issue 25, p3113 

    While cellular transformation by small DNA tumour viruses usually involves targeting the product of the p53 tumour suppressor gene by a virally encoded protein, none of the three polyoma virus (Py) specified T antigens have been observed to interact with p53. We show that primary mouse embryo...

  • Unique Expression of Human Papilloma Virus Type 5 and Type 16 in Esophageal Squamous Cell Carcinoma—A Case Report. Saravanan, Ramasamy; Youshya, Silva; Campbell, Fiona; Ran, Handong; Morris, Anthony I.; Proby, Charlotte // American Journal of Gastroenterology;Oct2006, Vol. 101 Issue 10, p2423 

    The role of human papilloma virus (HPV) in esophageal cancers from the low-incidence area (Western population) is unclear. We report a case of esophageal squamous papillomatosis associated with underlying esophageal squamous cell carcinoma (OSCC). The esophagectomy specimen confirmed presence of...

  • Epstein-Barr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2. O'Nions, Jenny; Allday, Martin J // Oncogene;10/16/2003, Vol. 22 Issue 46, p7181 

    Epstein-Barr virus (EBV) is involved in the pathogenesis of several B cell lymphoproliferations, but the precise contribution it makes to the aetiology of each remains unclear. In vitro, the virus has potent growth transforming activity and efficiently induces the continuous proliferation of...

  • Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6. Camus, S.; Menéndez, S.; Cheok, C. F.; Stevenson, L. F.; Laín, S.; Lane, D. P. // Oncogene;6/14/2007, Vol. 26 Issue 28, p4059 

    In vitro, high-risk human papillomavirus E6 proteins have been shown, in conjunction with E6-associated protein (E6AP), to mediate ubiquitination of p53 and its degradation by the 26S proteasome by a pathway that is thought to be analogous to Mdm2-mediated p53 degradation. However, differences...

  • TAp63α indirectly regulates a cutaneous HPV promoter through complex formation with Jun family members. Fei, J.-W.; Angel, P.; Wei, Q.-X.; de Villiers, E.-M. // Oncogene;6/29/2006, Vol. 25 Issue 28, p3914 

    The p63α isoforms of the p53 family have been demonstrated to play a crucial role in the development and differentiation of the skin. We show that expression of the TAp63α isoform leads to an upregulation of the cutaneous papillomavirus HPV 20 promoter, which is increased at least...

  • Differential localization of HPV16 E6 splice products with E6-associated protein. Vaeteewoottacharn, Kulthida; Chamutpong, Siriphatr; Ponglikitmongkol, Mathurose; Angeletti, Peter C. // Virology Journal;2005, Vol. 2, p50 

    High-risk Human Papillomavirus (HPV) is the etiological agent associated with the majority of anogenital cancers. The primary HPV oncogenes, E6 and E7, undergo a complex splicing program resulting in protein products whose purpose is not fully understood. Previous mouse studies have confirmed...

  • PS02.146: LARYNX-PRESERVING SURGERY FOR CERVICAL ESOPHAGEAL CANCER USING INTRAOPERATIVE ENDOSCOPIC SUBMUCOSAL DISSECTION: A CASE REPORT. Taniguchi, Yoshiki; Tanaka, Koji; Miyazaki, Yasuhiro; Makino, Tomoki; Takahashi, Tsuyoshi; Kurokawa, Yukinori; Yamasaki, Makoto; Nakajima, Kiyokazu; Mori, Masaki; Doki, Yuichiro // Diseases of the Esophagus;Sep2018, Vol. 31 Issue 13, p162 

    Background We sometimes experience cases of cervical esophageal cancer which requires laryngectomy due to spread of cancer to larynx. We report a case of esophageal cancer resection with preservation of larynx using intraoperative endoscopic submucosal dissection. Methods The patient was a...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics