Wnt signalling required for expansion of neural crest and CNS progenitors

Ikeya, Makoto; Lee, Scott M. K.
October 1997
Nature;10/30/1997, Vol. 389 Issue 6654, p966
Academic Journal
Presents research demonstrating that in the absence of both Wnt-1 and Wnt-3a genes there is a marked deficiency in neural crest derivatives and a pronounced reduction in dorsolateral neural precursors within the neural tube of a vertebrate central nervous system (CNS). Coexpression of Wnt-1 and Wnt-3a; Cause of phenotypes; Local Wnt signaling regulating the expansion of dorsal neural precursors; Model for Wnt action. INSET: Methods..


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