TITLE

Enrichment of MTHFR 677 T in a Chinese long-lived cohort and its association with lipid modulation

AUTHOR(S)
Ning-Yuan Chen; Cheng-Wu Liu; Li-Li Du; Li-Ping Xiao; Lin Ge; Yi-Yuan Wang; Zhen Wei; Hua-Yu Wu; Chen-Yuan Luo; Liang Liang; Jun-Hua Peng; Xiao-Qiu Luo; Rui-Xing Yin; Cuc Phuong Nguyen; Shang-Ling Pan
PUB. DATE
July 2014
SOURCE
Lipids in Health & Disease;2014, Vol. 13 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background Variants in Methylenetetrahydrofolate reductase (MTHFR) gene may result in a lowered catalytic activity and associate with subsequent elevated serum homocysteine (Hcy) concentration, abnormal DNA synthesis and methylation, cardiovascular risk, and unhealthy aging. Several investigations on the relationship of MTHFR C677T polymorphism with serum lipid profile and longevity have been conducted in some populations, but findings remain mixed. Herein, we sought to look at the association between MTHFR C677T and lipid profile in a longevous cohort in Bama, a well-known home of longevity in China. Methods Genotyping of MTHFR C677T was undertaken in 516 long-lived inhabitants (aged 90 and older, long-lived group, LG) and 493 healthy controls (aged 60-75, non long lived group, non-LG) recruited from Bama area. Correlation between MTHFR genotypes and lipids was then evaluated. Results T allele and TT genotype were significantly more prevalent in LG (P = 0.001 and 0.002, respectively), especially in females, than in non-LG. No difference in the tested lipid measures among MTHFR C677T genotypes was observed in LG, non-LG and total population (P > 0.05 for each). However, female but not male T carriers exhibited higher TC and LDL-C levels than did T noncarriers in the total population and in LG after stratification by sex (P < 0.05 for each). These differences did not however remain through further subdivision by hyperlipidemia and normolipidemia. Conclusion The higher prevalence of MTHFR 677 T genotypes and its modest unfavorable impact on lipids in Bama long-lived individuals may imply an existence of other protective genotypes which require further determination.
ACCESSION #
97103458

 

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