TITLE

Evaluation of Antioxidant and α-Glucosidase Inhibitory Activities of Some Subtropical Plants

AUTHOR(S)
Prihantini, Amalia Indah; Sanro Tachibana; Kazutaka Itoh
PUB. DATE
May 2014
SOURCE
Pakistan Journal of Biological Sciences;2014, Vol. 17 Issue 10, p1106
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The antioxidant and α-glucosidase inhibitoiy activities of the methanolic leaf extracts of some subtropical plants were evaluated in the present study. Antioxidant activity was evaluated based on 1,1-diphenyl-2-piciylhydrazyl radical scavenging activity, reducing power, hydrogen peroxide and β-carotene bleaching assays. α-Glucosidase inhibitoiy activity and enzyme kinetics as well as the total phenolic content of the extracts were also investigated. Elaeocarpus sylvestris extract had the highest activities on all the antioxidant assays performed such as DPPH scavenging activity (IC50 12.7±0.5 μg mL-1), reducing power (491.1±6.3 mg QE g-1 dry extract), hydrogen peroxide (IC50 65.6±0.4 μg mL-1) and β-carotene bleaching assays (IC50 5.1+1.9 μg mL-1). The total phenolic content of the E. sylvestris extract also had the liighest values for gallic acid, quercetin and rutin equivalents (353.8±28.6 mg GAEg-1 dry extract; 294.9±24.5 mg QEg-1 dry extract; 663.0±52.3 mg RE g-1 dry extract, respectively), α - Glueos idas e inhibition assay revealed that Distylium racemosum had the highest activity with an IC50 value of 22.6±1.9 μg mL-1. The results of the present study revealed the potencies of E. sylvestris, D. racemosum, Acer mono Maxim and Liquidambar styraciflua as alternative sources for antioxidants and a-glucosidase inhibitors.
ACCESSION #
97074119

 

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