Primary squamous cell of the thyroid-an abbreviated clinical presentation

Lui, Justin T.; Khalil, Moosa N.; Chandarana, Shamir P.
July 2014
Journal of Otolaryngology -- Head & Neck Surgery;2014, Vol. 43 Issue 1, p51
Academic Journal
Background. Lacking any squamous epithelium, thyroid gland with primary squamous cell carcinoma (PSCC) proves to be an etiopathophysiological quandary. Two major theories do exist, though few cases have been documented to support either. We present a case that supports the “metaplasia” theory, which serves to enhance our understanding of a disease that carries with it a very poor prognosis. Case presentation. We present a case of an extremely advanced, primary squamous cell carcinoma of the thyroid with distant metastases in a thirty-six year-old male. Dying of airway compromise seventeen days following his admission, this is the shortest median survival of all documented cases. Conclusion. In addition to being the most abbreviated time period between presentation and death of all documented thyroid primary squamous cell carcinomas, we share the fifth case of thyroid PSCC in the setting of lymphocytic thyroiditis. This case should build awareness of the aggressivity of the disease and the lack of established diagnostic criteria.


Related Articles

  • Primary squamous cell carcinoma of thyroid: a case report and review of literature.  // Head & Neck Oncology; 

    Background: Thyroid gland lacks squamous epithelium (except in some rare situations like embroyonic remnants or in inflammatory processes); for that reason the primary squamous cell carcinoma (SCC) of thyroid is extremely rare entity, seen only in less than 1% of all thyroid malignancies and is...

  • Palliative Radiation in Primary Squamous Cell Carcinoma of Thyroid: A Rare Case Report. Ghoshal, Sushmita; Bhattacharyya, Tapesh; Sood, Ashwani; Tyagi, Ruchita // Indian Journal of Palliative Care;Sep-Dec2013, Vol. 19 Issue 3, p192 

    Primary squamous cell carcinoma of the thyroid is an extremely rare neoplasm with aggressive behavior. Until date, only around 60 cases have been reported in the literature. Primary treatment of the patient is radical surgery. With optimum treatment survival is not more than 6 months in this...

  • Acantholytic squamous cell carcinoma of the maxilla: Unusual location and aggressive behavior of a rare histologic variant. Ozgursoy, Ozan Bagis; Tulunay, Ozden; Muz, Sami Engin; Aslan, Gaffar; Kucuk, Babur // ENT: Ear, Nose & Throat Journal;Sep2013, Vol. 92 Issue 9, pE22 

    Acantholytic squamous cell carcinoma (ASCC) of the mucosal membranes has been documented sporadically. The highly aggressive behavior of a mucosal ASCC arising in the oral cavity has been recently reported. To the best of our knowledge, only 1 autopsy case of maxillary ASCC previously has been...

  • Acantholytic Variant of Bowen's Disease with Micro‑invasive Squamous Cell Carcinoma: A Case Report of a Unique Variant. Pai, Kanthilatha; Shetty, Shricharith; J., Padmapriya; Pai, Sathish; Rao, Lakshmi // Indian Journal of Dermatology;Nov/Dec2014, Vol. 59 Issue 6, p1 

    Bowen's disease is generally regarded as premalignant dermatoses. The disease affects both skin and the mucosa and has the potential to progress to invasive squamous cell carcinoma. There are descriptions of several histological variants of Bowen's disease like psoriasiform, atrophic, pagetoid,...

  • Biological Behavior of Papillary Carcinoma of the Thyroid Including Squamous Cell Carcinoma Components and Prognosis of Patients Who Underwent Locally Curative Surgery. Ito, Yasuhiro; Hirokawa, Mitsuyoshi; Higashiyama, Takuya; Kihara, Minoru; Tomoda, Chisato; Takamura, Yuuki; Kobayashi, Kaoru; Miya, Akihiro; Miyauchi, Akira // Journal of Thyroid Research;2012, p1 

    Thyroid carcinoma showing squamous differentiation throughout the entire lesion is diagnosed as squamous cell carcinoma of the thyroid (SCCT) in the WHO classification. This entity is a rare disease and shows a dire prognosis; however, squamous differentiation ismore frequently detected in only...

  • Cervix carcinoma and incidental finding of medullary thyroid carcinoma by 18F-FDG PET/CT -- clinical case. Chaushev, Borislav; Bochev, Pavel; Klisarova, Anelia; Yordanov, Kaloyan; Encheva, Elitsa; Dancheva, Jivka; Yordanova, Cvetelina; Hristozov, Kiril; Krasnaliev, Ivan; Radev, Radoslav; Nenkov, Rumen // Nuclear Medicine Review;2014, Vol. 17 Issue 2, p97 

    Thyroid nodules are encountered in clinical practice during the diagnostic procedures or patients' follow-up due to other diseases quite far from the thyroid gland with prevalence 4-50% in general population, depending on age, diagnostic method and race. The prevalence of thyroid nodules...

  • Papillary thyroid carcinoma and laryngeal squamous cell carcinoma manifesting as a collision tumor of the neck: A case report. XIN WANG; XIANG-YAN CUI; NING FANG; WEI-LUN CHEN; HONG YU; WEI ZHU // Oncology Letters;2013, Vol. 6 Issue 6, p1616 

    A 55-year-old male presented with a rapidly expanding mass on the right side of the neck and progressive hoarseness. An electronic laryngoscopy and a computed tomography scan were performed, and the patient was subsequently diagnosed with tumors of the larynx and the thyroid gland. An en bloc...

  • Insight to neoplastic thyroid lesions by fine needle aspiration cytology. Rangaswamy, M; Narendra, Kl; Patel, S; Gururajprasad, C; Manjunath, Gv // Journal of Cytology;Jan-Mar2013, Vol. 30 Issue 1, p23 

    Background: Fine needle aspiration cytology (FNAC) is a valuable adjunct to pre‑operative screening in the diagnosis of thyroid nodules, and in most cases, it can distinguish between benign and malignant lesions. Aim: To study the cytology of neoplastic thyroid lesions to minimize...

  • Thyroid cancer: zealous imaging has increased detection and treatment of low risk tumours. Brito, Juan P; Morris, John C; Montori, Victor M // BMJ: British Medical Journal;9/7/2013, Vol. 347 Issue 7923, p18 

    Clinical context-Thyroid cancer is the most common endocrine malignancy and one of the fastest growing diagnoses Diagnostic change-Introduction of neck ultrasonography into routine endocrinological practice in the 1980s with guided biopsy in the late 1990s, plus increased use of computed...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics