Aminoglycoside ear drops and ototoxicity

Helal, Amal
April 1997
CMAJ: Canadian Medical Association Journal;04/01/97, Vol. 156 Issue 7, p1056
Academic Journal
Describes the ototoxic side effects of aminoglycoside ear drops from the cases reported in Canada. Passage of the ear drops into the middle ear through a perforation in the tympanic membrane; Cases reported in the Canadian Adverse Drug Reaction Monitoring Program; Precautionary measures in the treatment of ear infections.


Related Articles

  • Action call to halt antibiotic-induced hearing loss. Abdulla, Sara // BMJ: British Medical Journal (International Edition);9/14/96, Vol. 313 Issue 7058, p648 

    Reports on a proposal for the prevention of drug-induced deafness. Effect of aminoglycoside abuse on hearing; Role of free radicals as toxic agents; Efforts for the prevention of aminoglycoside ototoxicity.

  • Antioxidant defense against anthracycline cardiotoxicity by metallothionein. Kang, Y. James // Cardiovascular Toxicology;2007, Vol. 7 Issue 2, p95 

    Anthracycline cardiotoxicity is related to oxidative stress generated from the metabolism of anthracyclines in the heart. Studies using transgenic mice with high levels of antioxidants such as catalase or metallothionein (MT) specifically in the heart have demonstrated that elevation of cardiac...

  • How to avoid complications with aminoglycoside therapy.  // Geriatrics;Feb99, Vol. 54 Issue 2, p58 

    Presents an abstract of the article `Risk factors for toxicity in elderly patients given aminoglycosides once daily,' by D.L. Paterson, J.M.B. Wagener, et al which appeared in the November 13, 1998 issue of the `Journal of General Internal Medicine.'

  • Single or multiple daily doses of aminoglycosides: A meta-analysis. Barza, Michael; Ioannidis, John P.A. // BMJ: British Medical Journal (International Edition);2/10/96, Vol. 312 Issue 7027, p338 

    Assesses the effectiveness of aminoglycosides given by single daily dose compared with multiple daily doses. Uses of aminoglycosides; Concerns about the toxicity of the drug.

  • Commentary: Single daily dose of aminoglycoside is the preferred mode of administration. Smaill, Fiona // BMJ: British Medical Journal (International Edition);2/10/96, Vol. 312 Issue 7027, p344 

    Opinion. Focuses on the preference for single daily dose of aminoglycoside. Benefits from one single dosing.

  • Mechanism and prevention of aminoglycoside ototoxicity... Priuska, Eric M.; Schacht, Jochen // ENT: Ear, Nose & Throat Journal;Mar1997, Vol. 76 Issue 3, p164 

    Presents the use of isolated hair cells in the study of aminoglycoside ototoxicity and information on the molecular mechanism of ototoxicity. Toxic side effects of aminoglycoside antibiotics; Effectivity of aminoglycoside; First drug to combat tuberculosis; Two approaches in controlling the...

  • Monitoring aminoglycoside level. Banerjee, Suryabrata; Narayanan, Manjusha; Gould, Kate // BMJ: British Medical Journal;10/13/2012, Vol. 345 Issue 7878, p41 

    Aminoglycosides are potent antibiotics, but monitoring of therapy is essential to ensure optimal treatment and prevent toxicity. This article reviews the available evidence for this evolving subject.

  • Other topical agents are safer and just as effective. Rutka, John // ENT: Ear, Nose & Throat Journal;Jan2003 Supplement 1, Vol. 82 Issue 1, p15 

    Presents a study that discussed other topical agents that are safer than topical aminoglycosides. Aminoglycoside persistence; Reasons behind the sensitivity of people living in the Far East and Middle East to the effects of aminoglycosides; Most disconcerting aspect of topical aminoglycoside...

  • New developments in our understanding of ototoxicity. Roland, Peter S. // ENT: Ear, Nose & Throat Journal;Sep2004 Supplement 4, Vol. 83, p15 

    Tackles a variety of issues concerning ototoxicity in relation to aminoglycoside therapy. Mechanism of aminoglycoside ototoxicity; Genetic aspects of aminoglycoside ototoxicity; Ways to prevent aminoglycoside toxicity.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics