Genetic polymorphisms in biotransformation enzymes in Crohn's disease: association with microsomal epoxide hydrolase
- Susceptibility to Crohn's disease may lurk in enzyme mutation. // Journal of Medical Genetics;Nov2003, Vol. 40 Issue 11, p836
Discusses a preliminary study of genetic polymorphisms affecting transforming enzymes in the gut. Characterization of microsomal epoxide hydrolase as a likely candidate for susceptibility to Crohn's disease; Series of genes coding for detoxifying enzymes.
- Polymorphic Drug Metabolism in Anaesthesia. Restrepo, Juan G.; Garcia-Martín, Elena; Martínez, Carmen; Agúndez, José A. G. // Current Drug Metabolism;Mar2009, Vol. 10 Issue 3, p236
A substantial part of the interindividual variability in response to drugs and xenobiotics is related to genetically-determined impairment in drug metabolism. Several drug-metabolising enzymes are polymorphic in humans and often polymorphisms are strongly related to altered drug biodisposition...
- Bioactivation of cyclophosphamide: the role of polymorphic CYP2C enzymes. Griskevicius, Laimonas; Yasar, Ümit; Sandberg, Mia; Hidestrand, Mats; Eliasson, Erik; Tybring, Gunnel; Hassan, Moustapha; Dahl, Marja-Liisa // European Journal of Clinical Pharmacology;Jun2003, Vol. 59 Issue 2, p103
Several-fold differences have been observed among patients in the biotransformation of cyclophosphamide. The aim of this study was to investigate the contribution of CYP2C9 and CYP2C19 and their polymorphisms to the variability of cyclophosphamide activation. The formation of...
- Pharmacogenetics of human cytosolic sulfotransferases. Nowell, S.; Falany, C. N. // Oncogene;3/13/2006, Vol. 25 Issue 11, p1673
Cytosolic sulfotransferases (SULTs) are phase II detoxification enzymes that are involved in the biotransformation of a wide variety of structurally diverse endo- and xenobiotics, including many therapeutic agents and endogenous steroids. Single-nucleotide polymorphisms (SNPs) in SULTs have...
- Investigation of the Association between Genetic Polymorphism of Microsomal Epoxide Hydrolase and Primary Brain Tumor Incidence. Aydin, Ali; Pinarbasi, Hatice; Gurelik, Mustafa // Molecular Biology International;2013, p1
mEH is a critical biotransformation enzyme that catalyzes the conversion of xenobiotic epoxide substrates into more polar diol metabolites: it is also capable of inactivating a large number of structurally different molecules. Two polymorphisms affecting enzyme activity have been described in...
- Polymorphisms of toxifying and detoxifying hepatic enzymes in amyotrophic lateral sclerosis. Bachus R; Neubert K; Roots I; Prudlo J; Brockm''ller J; Ludolph A C; Bachus, R; Neubert, K; Roots, I; Prudlo, J; Brockmöller, J; Ludolph, A C // Journal of Neurology, Neurosurgery & Psychiatry;Aug2003, Vol. 74 Issue 8, p1161
No abstract available.
- Biotransformation of ginsenosides by hydrolyzing the sugar moieties of ginsenosides using microbial glycosidases. Chang-Su Park; Mi-Hyun Yoo; Kyeong-Hwan Noh; Deok-Kun Oh // Applied Microbiology & Biotechnology;Jun2010, Vol. 87 Issue 1, p9
Ginsenosides are the principal components responsible for the pharmaceutical activities of ginseng. The minor ginsenosides, which are also pharmaceutically active, can be produced via the hydrolysis of the sugar moieties in the major ginsenosides using acid hydrolytic, heating, microbial, and...
- Functional Genetic Variants in the 3â€²-Untranslated Region of Sulfotransferase Isoform 1A1 (SULT1A1) and Their Effect on Enzymatic Activity. Yu, Xinfeng; Dhakal, Ishwori B.; Beggs, Marjorie; Edavana, Vineetha Koroth; Williams, Suzanne; Zhang, Xuemei; Mercer, Kelly; Ning, Baitang; Lang, Nicholas P.; Kadlubar, Fred F.; Kadlubar, Susan // Toxicological Sciences;Dec2010, Vol. 118 Issue 2, p391
Sulfotransferase isoform 1A1 (SULT1A1) is the most highly expressed hepatic sulfotransferase and is involved in the biotransformation of a wide variety of endo- and xenobiotics. A common single nucleotide polymorphism (SNP) in the coding region of SULT1A1, several proximal promoter SNPs, and...
- Association of the CYP1A1*2A, GSTT1 null, GSTM1 null, mEPHX*3, and XRCC1-399 genetic polymorphisms with ulcerative colitis. Buyukgoze, Ozgen; Osmanoglu, Necla; Arslan, Sevki; Sen, Alaattin // International Journal of Colorectal Disease;Apr2013, Vol. 28 Issue 4, p593
A letter to the editor is presented regarding the difference of genetic polymorphisms in biotransformation enzymes to ulcerative colitis patients in various healthy controls including cytochrome P450 1A1 (CYP1A1), glutathione S-transferase mu-1 (GSTM1), and microsomal epoxide hydrolase (EPXH).