COX-2 dependent inflammation increases spinal Fos expression during rodent postoperative ileus
- Abdominal Cocoon: An Unusual Cause of Subacute Intestinal Obstruction. Shah, Md.; Gedam, B.; Sonarkar, R.; Gopinath, K. // Indian Journal of Surgery;Jun2013 Supplement, Vol. 75, p391
We report an unusual cause of subacute intestinal obstruction in a young adolescent girl, which is a nontubercular abdominal cocoon. Barium meal follow-through revealed 'cauliflower'-like appearance of small bowel. The patient underwent an exploratory laparotomy showing thick fibrous-like...
- LAPAROSCOPY IN THE DIAGNOSIS AND TREATMENT ACUTE INTESTINAL OBSTRUCTION. Abdulayev, Magomed A.; Avdeev, Alexey M.; Abdukhalimov, Karim S.; Artukhov, Sergey V.; Ezzeddin, Ayeb // Vestnik Sankt-Peterburgskogo Universiteta, Seriia 11: Medicina;2015, Issue 1, p10
An analysis of case histories of 67 patients aged 18 to 85 years, operated in the Alexander hospital for acute intestinal obstruction from 2006 to 2013 using laparoscopy, was performed. 40 (59,7%) patients were operated on for adhesive acute intestinal obstruction laparoscopically. 16 (23,8%) of...
- Foreword. Huskisson, Edward C. // Inflammopharmacology;2002, Vol. 10 Issue 3, p157
Explains that the development of COX-2 inhibitors should cause doctors to abandon old drugs. Illustration on the effectiveness of using COX-2 inhibitors together with older drugs to relieve patients of suffering; Information on NSAIDS and COX-1 inhibitors.
- Newly Identified RNA Binding Protein May Assist in Cancer Cell Destruction. Holland-Moritz, Pam // Drug Discovery & Development;May2003, Vol. 6 Issue 5, p22
Reports on Washington University School of Medicine researchers' identification of a protein that can help explain one the peculiarities of COX-2. Description of the RNA-binding protein called CUGBP2; Ability to inhibit the translation of the COX-2 protein which halts prostaglandin synthesis.
- EXPRESSION OF GLUCOCORTICOID RECEPTORS AND CYCLOOXYGENASE-2 IN NASAL POLYPS FROM NONALLERGENIC PATIENTS. Byung-heon Lee; Chang-bae Yun; Jang, Tae-jung // Annals of Otology, Rhinology & Laryngology;Jan2002, Vol. 111 Issue 1, p61
Examines the presence of glucocorticoid receptors (GRs) and cyclooxygenase-2 (COX-2) in the nasal polyps of nonallegic patients. Presence of COX-2 in the cytoplasm of surface mucosa; Association of GR labelling to the cytoplasm and nucleus of surface mucosa; Treatment suggested.
- Gastrointestinal Safety of Selective COX-2 Inhibitors. Hawkey, C.J.; Skelly, M.M. // Current Pharmaceutical Design;Jun2002, Vol. 8 Issue 12, p1077
It appears that selective Cox-2 inhibitors do not affect the gastro duodenal mucosa whilst having antiinflammatory and analgesic efficacy similar to non-selective NSAIDs. Two broad categories of drugs are Cox-2 selective: coxibs and a number of pre-existing NSAIDs retrospectively found to have...
- Comparative Analgesia, Cardiovascular and Renal Effects of Celecoxib, Rofecoxib and Acetaminophen (Paracetamol). Graham, Garry G.; Graham, Robert I.; Day, Richard O. // Current Pharmaceutical Design;Jun2002, Vol. 8 Issue 12, p1063
Comparisons are made between the specific COX-2 inhibitors, celecoxib and rofecoxib, and acetaminophen. The specific COX-2 inhibitors are a significant advance in therapy because their antiinflammatory, analgesic and antipyretic activities are associated with a high degree of gastrointestinal...
- Preface. Brooks, Peter M. // Current Pharmaceutical Design;Jun2002, Vol. 8 Issue 12, p1
Introduces the June 2002 issue of 'Current Pharmaceutical Design,' which reviews some of the issues relating to the area of cyclooxygenase (Cox)-2 specificity and major gastrointestinal outcomes trials that have been published on the Cox specific inhibitors. Role of Cox-1 and Cox-2 in the...
- Recent Advances in Inducible Cyclooxygenase (COX-2) Inhibition. de Leval, Xavier; Delarge, Jacques; Somers, Fabian; de Tullio, Pascal; Henrotin, Yves; Pirotte, Bernard; Dogne, Jean-Michel // Current Medicinal Chemistry;Oct2000, Vol. 7 Issue 10, p1041
Cyclooxygenase is the key enzyme in the biosynthesis of prostanoids, biologically active substances that are involved in several physio- logical processes but also in pathological conditions such as inflammation. Since ten years now, it is well known that this enzyme exists under two forms: a...