TITLE

Dendritic cells and immune regulation in the liver

AUTHOR(S)
Lau, A.H.; Thomson, A.W.
PUB. DATE
February 2003
SOURCE
Gut;Feb2003, Vol. 52 Issue 2, p307
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Hepatic dendritic cells (DC) unquestionably play important roles in the induction and regulation of immune responses. Due to their paucity, functional characterisation of these important antigen presenting cells has been slow but use of DC growth factors (in particular GM-CSF and FIt3L) that markedly enhance their numbers has proved helpful in furnishing adequate study material. While there is growing evidence that DC function is affected in the pathogenesis of liver disease, most work to date has been performed on non-hepatic DC. Increasing knowledge of hepatic DC biology is likely to improve our understanding of disease pathogenesis and resistance to and therapy of liver disease.
ACCESSION #
9704727

 

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