Gliadin peptide specific intestinal T cells in coeliac disease
- In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope. Anderson, Robert P.; Degano, Pilar; Godkin, Andrew J.; Jewell, Derek P.; Hill, Adrian V.S. // Nature Medicine;Mar2000, Vol. 6 Issue 3, p337
Celiac disease (CD) is an increasingly diagnosed enteropathy (prevalence, 1:200-1:300) that is induced by dietary exposure to wheat gliadins (as well as related proteins in rye and barley) and is strongly associated with HLA-DQ2 (Î±1[sup *]0501, Î²1[sup *]0201), which is present in over 90%...
- ImmusanT Seeks to Restore Gluten Tolerance with Vaccine. Powers, Marie // BioWorld Today;3/23/2011, Vol. 22 Issue 56, p1
The article reports that ImmusanT Inc. has entered the market for the drug treatment of inherited automimmune disorder celiac disease. The company has opened a facility in Cambridge, Massachusetts that will focus on the creation of an immunotherapeutic vaccines, as well as a diagnostic and...
- Novel Perspectives in Celiac Disease Therapy. Sanz, Yolanda // Mini Reviews in Medicinal Chemistry;Mar2009, Vol. 9 Issue 3, p359
Currently the only treatment for celiac disease is adherence to a strict gluten-free diet; however, compliance with this diet is complex and other alternatives are called for. Herein, we review recent developments in the design of novel therapeutic strategies to counteract the pathogenic effects...
- Investigation of QT interval in adult coeliac disease. Corazza, G.R.; Frisoni, M.; Filipponi, C.; Gullo, L.; Poggi, V.M.; Gasbarrini, G. // BMJ: British Medical Journal (International Edition);5/16/92, Vol. 304 Issue 6837, p1285
Examines the association between mortality and adult coeliac disease. Influence of QT interval prolongation on the risk of death; Use of electrocardiography on the prolonged QT interval; Factors affecting the long QT syndrome.
- Antiendomysial antibody detection in fecal supernatants: in vivo proof that small bowel mucosa is the site of antiendomysial antibody production. Picarelli, Antonio; Sabbatella, Luigi; Di Tola, Marco; Di Cello, Teresa; Vetrano, Stefania; Anania, Maria Cristina // American Journal of Gastroenterology;Jan2002, Vol. 97 Issue 1, p95
OBJECTIVES:Serum antiendomysial antibodies (EMAs), highly sensitive and specific serological markers of celiac disease (CD), are detectable in culture media of biopsy samples from CD patients. This finding can be considered an in vitro evidence that intestinal mucosa is a site of EMA production....
- Gastric emptying in coeliac disease. Hamlyn, Adrian N.; McKenna, K.; Douglas, Adrian P. // British Medical Journal;5/14/1977, Vol. 1 Issue 6071, p1257
Investigates the solid-phase emptying with liquid emptying in a group of patients with coeliac disease. Evidence of accelerated emptying in coeliac disease; Augmented blood concentrations seen after ingestion of propranolol by patients with coeliac disease; Gastrointestinal symptoms of the...
- worm cure? // Good Health (Australia Edition);Dec2009, p42
The article presents the study on the use of hookworms for the treatment of coeliac disease in Australia.
- The strange look of a forgotten disease. Warburton, Louise // GP: General Practitioner;2/17/2003, p71
Presents the case study of a patient encountered by the author, who was suffering from coeliac disease. Medical condition of the patient; Test ran on the patient for the diagnosis; Diet given to the patient.
- A Clinical Conversation: Celiac Disease and Gluten-Related Disorders: Integrative Clinical Approaches. Fasano, Alessio // Alternative & Complementary Therapies;Feb2015, Vol. 21 Issue 1, p18
The article presents questions and answers related to treatment celiac disease including the reason behind increased prevalence of celiac disease, how alterations in antigen presentation can predispose individuals to celiac disease and how impaired intestinal permeability affects zonulin.