TITLE

GSTT1 Polymorphism and the Risk of Developing Prostate Cancer

AUTHOR(S)
Tian-Biao Zhou; Drummen, Gregor P. C.; Zong-Pei Jiang; Yuan-Han Qin
PUB. DATE
July 2014
SOURCE
American Journal of Epidemiology;Jul2014, Vol. 180 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A possible association between glutathione S-transferase theta 1 gene (GSTT1) polymorphism and the risk of developing prostate cancer is currently hotly debated, but evidence from various epidemiologic studies remains unclear. This investigation was performed to assess whether an association between GSTT1 polymorphism and prostate cancer risk exists by using meta-analysis to combine comparable studies, thereby increasing sample size and statistical significance, as well as to identify patterns in various studies. The association reports were identified from the PubMed database and the Cochrane Library on March 1, 2013, and data from eligible studies (from 1999-2012) were synthesized. Thirty-eight reports were included in this meta-analysis on the association of the null genotype of GSTT1 with prostate cancer risk. No solid association between the GSTT1 null genotype and prostate cancer risk could be established for the overall population (odds ratio = 1.11,95% confidence interval: 0.97,1.27; P=0.13). However, the GSTT1 null genotype was distinctly associated with prostate cancer risk in Caucasians (odds ratio = 1.24, 95% confidence interval: 1.03,1.48, P=0.02). In conclusion, the GSTT1 null genotype is associated with prostate cancer risk in Caucasians, but not in the overall population.
ACCESSION #
96993958

 

Related Articles

  • The validity and reliability of mixed-dentition analysis methods A systematic review. Luu, Nighe S.; Mandich, Marie-Alice; Tieu, Long D.; Kaipatur, Meelambar; Flores-Mir, Carlos // Journal of the American Dental Association (JADA);Oct2011, Vol. 142 Issue 10, p1143 

    The article presents a literature review which determines the reliability and validity of mixed-dentition analysis (MDA) methods in predicting permanent tooth size in the mixed dentition. It says that the author selected and analyzed 39 articles in eight online databases for studies of MDA,...

  • APC Polymorphisms and the Risk of Colorectal Neoplasia: A HuGE Review and Meta-Analysis. Liang, Jing; Lin, Chunqing; Hu, Fulan; Wang, Fan; Zhu, Lin; Yao, Xiaoping; Wang, Yibaina; Zhao, Yashuang // American Journal of Epidemiology;Jun2013, Vol. 177 Issue 11, p1169 

    Adenomatous polyposis coli gene (APC) polymorphisms may influence the risk for colorectal neoplasia. However, results thus far have been inconclusive. We performed a systematic literature search of the Medline, Embase, Cochrane Collaboration, and HuGE databases and reviewed the references of...

  • Austrian catalogue of services of physical medicine - empirical basis of the effectiveness of the contents. Wilbacher, Ingrid; Brandst├Ątter, Silvia; Kruzic, Nives; Gerner, Gabriele; Kiesl, Ute // GMS Health Technology Assessment;2013, Vol. 9, p1 

    Background: An existing catalogue of services of physical medicine as a basic guideline for contracts with physicians and institutes in the Austrian Social Health Insurance Setting was checked for the evidence of the services. The main focus for this is the outpatient setting. Method: Based on...

  • Reviewing literature for research: Doing it the right way. Poojary, Shital Amin; Bagadia, Jimish Deepak // Indian Journal of Sexually Transmitted Diseases;Jul-Dec2014, Vol. 35 Issue 2, p85 

    In an era of information overload, it is important to know how to obtain the required information and also to ensure that it is reliable information. Hence, it is essential to understand how to perform a systematic literature search. This article focuses on reliable literature sources and how to...

  • Delirium and the Family Caregiver: The Need for Evidence-based Education Interventions. Carbone, Meredith K.; Gugliucci, Marilyn R. // Gerontologist;Jun2015, Vol. 55 Issue 3, p345 

    Delirium, an acute confusional state, is experienced by many older adults. Although there is substantial research on risk factors and etiology, we hypothesized that there is a dearth of information on educating the family caregivers of delirious older patients. A date-specific (2000-2013)...

  • Complementary feeding: a critical window of opportunity from six months onwards. Du Plessis, L. M.; Kruger, H. S.; Sweet, L. // South African Journal of Clinical Nutrition;2013 Supplement, Vol. 26, pS129 

    This paper aims to propose evidence-based, paediatric food-based dietary guidelines on the complementary feeding period, from six to 24 months, of South Africa. A growing body of evidence supports the World Health Organization recommendation that, following six months of exclusive breastfeeding,...

  • Adverse Events of Massage Therapy in Pain-Related Conditions: A Systematic Review. Ping Yin; Ningyang Gao; Junyi Wu; Litscher, Gerhard; Shifen Xu // Evidence-based Complementary & Alternative Medicine (eCAM);2014, Vol. 2014, p1 

    Pain-related massage, important in traditional Eastern medicine, is increasingly used in the Western world. So the widening acceptance demands continual safety assessment. This review is an evaluation of the frequency and severity of adverse events (AEs) reported mainly for pain-related massage...

  • Lessons Learnt from Evidence-Based Approach of Using Chinese Herbal Medicines in Liver Cancer. Zhan Zheng; Wiliam Chi-Shing Cho; Ling Xu; Juyong Wang; Daniel Man-Yuen Sze // Evidence-based Complementary & Alternative Medicine (eCAM);2013, Vol. 2013, p1 

    This paper is a systematic review of evidence-based studies of the effectiveness of Chinese herbal medicine (CHM) in the treatment of liver cancer. After a detailed analysis of the literature, five animal studies and four human clinical trials met the criteria for inclusion. Analysis revealed...

  • Future Research in Health Information Technology: A Review. Hemmat, Morteza; Ayatollahi, Haleh; Reza Maleki, Mohammad; Saghafi, Fatemeh // Perspectives in Health Information Management;Winter2017, p1 

    Introduction: Currently, information technology is considered an important tool to improve healthcare services. To adopt the right technologies, policy makers should have adequate information about present and future advances. This study aimed to review and compare studies with a focus on the...

Share

Read the Article

Courtesy of

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics