Non-motor symptoms in Thai Parkinson's disease patients: Prevalence, manifestation and health related quality of life

Praween Lolekha; Kongkiat Kulkantrakorn
June 2014
Neurology Asia;Jun2014, Vol. 19 Issue 2, p163
Academic Journal
Background & Objective: Non-Motor Symptoms (NMS) are common in Parkinson's disease (PD). While prevalence of each NMS in Thai PD patients is unknown, these NMS might have an impact on patients' wellbeing. The aim of this study is to identify the prevalence, pattern and impact of NMS on the quality of life in Thai PD patients. Methods: A cross-sectional study in 115 PD patients was conducted at Thammasat University hospital. Subtype of PD, Schwab & England activity of daily living (ADL scale), Unified Parkinson's Disease Rating Scale (UPDRS) motor score and the modified Hoehn & Yahr (H&Y scale) were recorded. NMS and quality of life were assessed using Thammasat University Non-Motor Symptoms Questionnaire (TU-NMSQuest) and Parkinson's Disease Questionnaire-8 (PDQ-8). Results: All patients reported at least one NMS. A mean number of 15.94 ± 6.48 NMS was reported by each patient. Nocturia (79.1%), urinary urgency (73%), and fatigue (71.3%) were the most prevalent NMS. Significant correlations were observed between TU-NMSQuest and UPDRS motor score, H&Y scale, ADL scale, subtype of PD, and PDQ-8. Conclusion: NMS are common and have a significant impact on the quality of life in PD patients. Advanced disease stage, poorer motor or ADL function, and non-tremor dominant subtype are associated with a higher number of NMS and lower quality of life in Thai PD patients.


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