TITLE

Yes-associated protein (YAP) is differentially expressed in tumor and stroma according to the molecular subtype of breast cancer

AUTHOR(S)
Sang Kyum Kim; Woo Hee Jung; Ja Seung Koo
PUB. DATE
June 2014
SOURCE
International Journal of Clinical & Experimental Pathology;2014, Vol. 7 Issue 6, p3224
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
96961713

 

Related Articles

  • Metaplastic carcinoma show different expression pattern of YAP compared to triple-negative breast cancer. Kim, Hye; Kim, Sang; Jung, Woo; Koo, Ja // Tumor Biology;Feb2015, Vol. 36 Issue 2, p1207 

    The purpose of this study is to examine the expression of Yes-associated protein (YAP) in metaplastic carcinoma and compare to those of triple-negative breast carcinoma (TNBC) for investigation of its implication. Tissue microarrays containing 34 cases of metaplastic carcinoma and 175 cases of...

  • Yes-associated protein (YAP) functions as a tumor suppressor in breast. Yuan, M.; Tomlinson, V.; Lara, R.; Holliday, D.; Chelala, C.; Harada, T.; Gangeswaran, R.; Manson-Bishop, C.; Smith, P.; Danovi, S. A.; Pardo, O.; Crook, T.; Mein, C. A.; Lemoine, N. R.; Jones, L. J.; Basu, S. // Cell Death & Differentiation;Nov2008, Vol. 15 Issue 11, p1752 

    Yes-associated protein (YAP) has been shown to positively regulate p53 family members and to be negatively regulated by the AKT proto-oncogene product in promoting apoptosis. On the basis of this function and its location at 11q22.2, a site of frequent loss of heterozygosity (LOH) in breast...

  • Expression of Yes-associated protein (YAP) in metastatic breast cancer. Hye Min Kim; Woo Hee Jung; Ja Seung Koo // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 9, p11248 

    The purpose of this study was to investigate the expression of Yes-associated protein (YAP) in different metastatic sites in metastatic breast cancer and to determine the clinical implications of these patterns. Immunohistochemical staining was used to investigate the expression of YAP and...

  • The dual functions of YAP-1 to promote and inhibit cell growth in human malignancy. Wang, Hai; Du, Yu-Chen; Zhou, Xiao-jun; Liu, Hong; Tang, Shou-Ching // Cancer & Metastasis Reviews;Mar2014, Vol. 33 Issue 1, p173 

    The major functions of Hippo (Hpo) signaling pathway are to control cell growth, proliferation, and apoptosis. As its important downstream player, yes-associated protein (YAP)-1 was originally found to promote cell proliferation and transformation. Overexpression of YAP-1 has been linked to...

  • Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer. Jung, Yoon; Lee, Yu; Koo, Ja // Tumor Biology;Nov2015, Vol. 36 Issue 11, p8685 

    Cancer-associated fibroblasts (CAFs) play key roles in tumor microenvironment; they are thought to originate from adipocytes. This study aimed to evaluate CAF-related protein expression and its implications in breast cancer. Of the 939 enrolled breast cancer patients, 642 had fibrous and 297 had...

  • Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer. Vlug, Eva; Ven, Robert; Vermeulen, Jeroen; Bult, Peter; Diest, Paul; Derksen, Patrick // Cellular Oncology (2211-3428);Oct2013, Vol. 36 Issue 5, p375 

    Background: Yes Associated Protein (YAP) has been implicated in the control of organ size by regulating cell proliferation and survival. YAP is a transcriptional coactivator that controls cellular responses through interaction with TEAD transcription factors in the nucleus, while its...

  • Differential expression of cancer-associated fibroblast-related proteins according to molecular subtype and stromal histology in breast cancer. Park, Sung; Kim, Hye; Koo, Ja // Breast Cancer Research & Treatment;Feb2015, Vol. 149 Issue 3, p727 

    The purpose of this study aimed to investigate the clinicopathologic characteristics of breast cancer according to its cancer-associated fibroblast (CAF) phenotype. Immunohistochemistry staining of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER-2), Ki-67,...

  • Loss of Yes-associated protein (YAP) expression is associated with estrogen and progesterone receptors negativity in invasive breast carcinomas. Tufail, Rozina; Jorda, Mercy; Zhao, Wei; Reis, Isildinha; Nawaz, Zafar // Breast Cancer Research & Treatment;Feb2012, Vol. 131 Issue 3, p743 

    Yes-associated protein (YAP) is a well characterized transcriptional coactivator that interacts with various transcription factors and modulates their transcriptional activities. Phosphorylation of YAP by specific kinases regulates its cellular distribution and transcriptional activation...

  • Metabolic phenotypes in triple-negative breast cancer. Kim, Sewha; Kim, Do; Jung, Woo-Hee; Koo, Ja // Tumor Biology;Jun2013, Vol. 34 Issue 3, p1699 

    The aim of study was to investigate the metabolism of tumor and stromal cells necessary to determine differential tumor-stroma metabolic interactions according to the molecular subtypes of triple-negative breast cancer (TNBC). Tissues from 132 patients of TNBC were prepared for use as tissue...

  • YAP-1 Promotes Tregs Differentiation in Hepatocellular Carcinoma by Enhancing TGFBR2 Transcription. Fan, Ye; Gao, Yangjuan; Rao, Jianhua; Wang, Ke; Zhang, Feng; Zhang, Chuanyong // Cellular Physiology & Biochemistry (Karger AG);May2017, Vol. 41 Issue 3, p1189 

    Background/Aims: Immunosuppression is one of the hallmarks of cancer; however, its molecular mechanism remains unknown. In the present study, we sought to investigate the expression and activation of yes-associated protein 1 (YAP-1) and its roles in T cells within hepatocellular carcinoma (HCC)....

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics