TITLE

Loss of expression of MHC class I-related chain A (MICA) is a frequent event and predicts poor survival in patients with hepatocellular carcinoma

AUTHOR(S)
Jie Zhang; Zhuding Xu; Xingchun Zhou; Haibin Zhang; Ning Yang; Yousheng Wu; Yibing Chen; Guangshun Yang; Tingting Ren
PUB. DATE
June 2014
SOURCE
International Journal of Clinical & Experimental Pathology;2014, Vol. 7 Issue 6, p3123
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
96961645

 

Related Articles

  • Abnormal expression levels of sMICA and NKG2D are correlated with poor prognosis in pancreatic cancer. Jiong Chen; Hong Xu; Xing-Xing Zhu // Therapeutics & Clinical Risk Management;Jan2016, Vol. 12, p11 

    Soluble major histocompatibility complex class I-related chain A molecules (sMICA) and natural-killer group 2 member D (NKG2D) not only correlate with tumorigenesis and progression, but also with tumor invasion and metastasis. In this study, we used immunohistochem- istry to investigate the...

  • Inhibition of hepatitis B virus replication by small interference RNA induces expression of MICA in HepG2.2.15 cells. Kai-Fu Tang; Min Chen; Jing Xie; Guan-Bin Song; Yi-Song Shi; Qi Liu; Zhe-Chuan Mei; Steinle, Alexander; Hong Ren // Medical Microbiology & Immunology;Feb2009, Vol. 198 Issue 1, p27 

    Hepatitis B virus (HBV) replicates in most tumor tissues of patients with HBV-associated hepatocellular carcinoma (HCC). In the present study, we have shown that the expression of HBV in the HCC cell lines, HepG2 and Huh7, down-regulated the expression of MHC class I-related molecule A (MICA), a...

  • Effects of MICA Expression on the Prognosis of Advanced Non-Small Cell Lung Cancer and the Efficacy of CIK Therapy. Chen, Yu; Lin, Gen; Guo, Zeng-qing; Zhou, Zhi-feng; He, Zhi-yong; Ye, Yun-bin // PLoS ONE;Jul2013, Vol. 8 Issue 7, p1 

    Objective: To investigate the clinical significance of the expression of MHC class I chain-related gene A (MICA) in patients with advanced non-small cell lung cancer and explore the relationship between MICA expression and the efficacy of cytokine-induced killer cell (CIK) therapy for treating...

  • Will MICA Glitter for Recipients of Kidney Transplants? Flegel, Willy Albert // New England Journal of Medicine;9/27/2007, Vol. 357 Issue 13, p1337 

    This editorial comments on a study in this issue which looks at the role of the protein expressing the major-histocompatibility-complex (MHC) class I�related chain A (MICA) antigens in causing rejection in kidney transplants. Despite the huge advances in kidney transplantation and the...

  • Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells. Zhou, Yizhou; Stastny, Peter // Immunogenetics;Dec2002, Vol. 54 Issue 9, p671 

    MICA and MICB genes encode MHC class I chain-related proteins, which are polymorphic, do not appear to present peptides or associate with β2-microglobulin, and are expressed predominantly in epithelial cells, endothelial cells, fibroblasts and several cultured cell lines. Alternatively...

  • Interleukin-1β enhances the production of soluble MICA in human hepatocellular carcinoma. Kohga, Keisuke; Tatsumi, Tomohide; Tsunematsu, Hinako; Aono, Satoshi; Shimizu, Satoshi; Kodama, Takahiro; Hikita, Hayato; Yamamoto, Masashi; Oze, Tsugiko; Aketa, Hiroshi; Hosui, Atsushi; Miyagi, Takuya; Ishida, Hisashi; Hiramatsu, Naoki; Kanto, Tatsuya; Hayashi, Norio; Takehara, Tetsuo // Cancer Immunology, Immunotherapy;Sep2012, Vol. 61 Issue 9, p1425 

    The production of soluble major histocompatibility complex class I-related chain A (MICA) is thought to antagonize NKG2D-mediated immunosurveillance. Interleukin-1β (IL-1β) is elevated in patients with chronic hepatitis C (CH), and this might contribute to the escape of hepatocellular...

  • Antibodies against MICA Antigens and Kidney-Transplant Rejection. Zou, Yizhou; Stastny, Peter; S�sal, Caner; D�hler, Bernd; Opelz, Gerhard // New England Journal of Medicine;9/27/2007, Vol. 357 Issue 13, p1293 

    Background: Good HLA-A, HLA-B, and HLA-DR matches do not guarantee rejection-free renal transplantation. Some kidney transplants fail despite such matches, suggesting that other antigens might be targets for rejection. Major-histocompatibility-complex (MHC) class I�related chain A (MICA)...

  • The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia. Nückel, H.; Switala, M.; Sellmann, L.; Horn, P. A.; Dürig, J.; Dührsen, U.; Küppers, R.; Grosse-Wilde, H.; Rebmann, V. // Leukemia (08876924);Jun2010, Vol. 24 Issue 6, p1152 

    Soluble or membrane-anchored ligands of NKG2D and their receptor have a critical role in the elimination of tumor cells and disease progression. Plasma samples of 98 patients with B-cell chronic lymphocytic leukemia (CLL) were analyzed with specific ELISA systems for soluble major...

  • MHC I-related chain a expression in gastric carcinoma and the efficacy of immunotherapy with cytokine-induced killer cells. Yu Chen; Jing Lin; Zeng-Qing Guo; Wan-Song Lin; Zhi-Feng Zhou; Chuang-Zhong Huang; Qiang Chen; Yun-Bin Ye // American Journal of Cancer Research;2015, Vol. 5 Issue 10, p3221 

    Cytokine-induced killer (CIK) cells have shown promising activity against gastric cancer in vitro and in vivo. Previous studies showed that cell signaling through MHC I-related Chain A (MICA)-Natural killer group 2, member D (NKG2D) results in CIK cell activation leading to cytolytic activities...

  • Soluble MICA and a MICA Variation as Possible Prognostic Biomarkers for HBV-Induced Hepatocellular Carcinoma. Kumar, Vinod; Lo, Paulisally Hau Yi; Sawai, Hiromi; Kato, Naoya; Takahashi, Atsushi; Zhenzhong Deng; Urabe, Yuji; Mbarek, Hamdi; Tokunaga, Katsushi; Tanaka, Yasuhito; Sugiyama, Masaya; Mizokami, Masashi; Muroyama, Ryosuke; Tateishi, Ryosuke; Omata, Masao; Koike, Kazuhiko; Tanikawa, Chizu; Kamatani, Naoyuki; Kubo, Michiaki; Nakamura, Yusuke // PLoS ONE;Sep2012, Vol. 7 Issue 9, Special section p1 

    MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection and various types of stress. We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics