TITLE

Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review

AUTHOR(S)
McGuire, W.; Anthony, M.Y.
PUB. DATE
January 2003
SOURCE
Archives of Disease in Childhood -- Fetal & Neonatal Edition;Jan2003, Vol. 88 Issue 1, pF11
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: To determine if enteral feeding with donor human milk compared with formula milk reduces the incidence of necrotising enterocolitis (NEC) in preterm or Iow birthweight infants. Methods: Systematic review and meta-analysis of randomised controlled trials. Results: Four small trials, all initiated more than 20 years ago, fulfilled the prespecified inclusion criteria. None of the trials individually found any statistically significant difference in the incidence of NEC. However, meta-analysis found that feeding with donor human milk was associated with a significantly reduced relative risk (RR) of NEC. Infants who received donor human milk were three times less likely to develop NEC (RR 0.34; 95% confidence interval (CI) 0.12 to 0.99), and four times less likely to have confirmed NEC (RR 0.25; 95% CI 0.06 to 0.98) than infants who received formula milk. Conclusions: It may be appropriate to consider further larger trials to compare growth, development, and the incidence of adverse outcomes, including NEC, in preterm infants who receive donor human milk versus formula milk.
ACCESSION #
9694262

 

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