TITLE

Insulin Receptor Expression in Clear Cell Renal Cell Carcinoma and Its Relation to Prognosis

AUTHOR(S)
Lkhagvadorj, Sayamaa; Sung Soo Oh; Mi-Ra Lee; Jae Hung Jung; Hyun Chul Chung; Seung-Kuy Cha; Minseob Eom
PUB. DATE
July 2014
SOURCE
Yonsei Medical Journal;Jul2014, Vol. 55 Issue 4, p861
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: Both insulin and insulin-like growth factor (IGF)-1 signaling are key regulators of energy metabolism, cellular growth, proliferation, and survival. The IGF-1 receptor (IGF-1R) is overexpressed in most types of human cancers including renal cell carcinoma (RCC) with poor prognosis. Insulin receptor (IR) shares downstream effectors with IGF-1R; however, the expression and function of IR in the tumorigenesis of renal cancer remains elusive. Therefore, we examined the ex-pression of IR and its prognostic significance in clear cell RCC (CCRCC). Materials and Methods: Immunohistochemical staining for IR was performed on 126 formalin-fixed paraffin-embedded CCRCC tissue samples. Eight of these cases were utilized for western blot analysis. The results were compared with various clinico-pathologic parameters of CCRCC and patient survival. Results: IR was expressed in the nuclei of CCRCC tumor cells in 109 cases (87.9%). Higher IR expression was significantly correlated with the presence of cystic change, lower Fuhrman nuclear grade, lower pathologic T stage, and lower TNM stage, although it wasn't significantly related to diabetes status and patient survival. Western blot analyses supported the results of the immunohistochemistry studies. Conclusion: IR expression in CCRCC may be associated with favorable prognostic factors.
ACCESSION #
96804703

 

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