Intrafamilial transmission of hepatitis C virus in patients with hepatitis C and human immunodeficiency virus coinfection

Keiserman, Daniela R.; Both, Cristiane T.; Mattos, Angelo A.; Remiao, Jose; Alexandre, Claudio O.P.; Sherman, Kenneth E.
April 2003
American Journal of Gastroenterology;Apr2003, Vol. 98 Issue 4, p878
Academic Journal
: ObjectiveThe aim of this study was to determine whether hepatitis C virus (HCV)/HIV coinfection of index cases increases intrafamilial transmission (sexual and nonsexual contacts) of HCV.: MethodsWe prospectively enrolled 347 subjects, including 87 family members of 53 HCV/HIV-coinfected index cases and 134 family members of 73 HCV-monoinfected index cases, which served as a control group. All index cases and family members were interviewed, and a screening for HCV and HIV using enzyme-linked immunosorbent assays was performed. Positive samples were confirmed by polymerase chain reaction and tested for genotype and HCV RNA viral load. A meta-analysis designed to assess the pooled risk of sexual transmission of HCV among HCV/HIV-coinfected patients was performed.: ResultsAnti-HCV was detected in 2.2% of family members of HCV-monoinfected index cases and 2.3% of family members of HCV/HIV-coinfected index cases. Viral load was higher in coinfected index cases (7.2 × 106 mEq/ml) compared with HCV alone (1.9 × 106 mEq/ml), p = 0.01. HCV genotype concordance was observed in three family members of HCV-monoinfected index cases and in two family members of HCV/HIV-coinfected index cases. The pooled OR of the meta-analysis evaluating HIV as a cofactor of sexual transmission of HCV was 1.54 (95% CI = 0.76–3.12).: ConclusionsOur data demonstrate a low prevalence of intrafamilial transmission of HCV, independent of the presence of HCV/HIV coinfection. This finding is supported by meta-analysis, which failed to identify HIV as an important cofactor of sexual transmission in HCV/HIV-coinfected patients.


Related Articles

  • Hepatitis C: Causes.  // Hepatitis C (National Institute of Allergy/Infectious Disease);2009, p1 

    The article offers information on hepatitis C virus which causes hepatitis C or chronic liver disease.

  • Towards a Better Understanding of HCV Transmission and Course of Infection. Berger, A.; Doerr, H. // Infection;Jun2004, Vol. 32 Issue 3, p125 

    Presents an introduction to articles regarding hepatitis C virus transmission and its course of infection that appears in the June 2004 issue of the journal "Infection."

  • Editorial: Acute Hepatitis C: Epidemiology, Pathogenesis and Therapy. Fabris, Paolo // Current Pharmaceutical Design;Jun2008, Vol. 14 Issue 17, p1644 

    The article discusses various reports published within the issue including one on the epidemiology of hepatitis C virus (HCV) around the world and another on the immunological and therapeutic aspect of acute hepatitis C in HIV positive patients.

  • WHAT IS A PANDEMIC? Atkinson, Jim // Esquire;Jan2001, Vol. 135 Issue 1, p104 

    Provides information on Hepatitis C. Causes; Risk factors; Difference from Hepatitis A and B; Clinical manifestations of the disease.

  • Hepatitis C abroad.  // AIDS Patient Care & STDs;Nov98, Vol. 12 Issue 11, p874 

    Presents an update on hepatitis C virus (HCV) infection. Canadian officials' revision of estimates as to the number of individuals who contracted hepatitis C from contaminated blood; Number of Canadians infected with HCV between 1960 and 1992; Irish officials' efforts to identify women who may...

  • Type C-chronic hepatitis patients who had autoimmune phenomenon and developed jaundice during interferon therapy. Sezaki, Hitomi; Arase, Yasuji; Tsubota, Akihito; Suzuki, Yoshiyuki; Kobayashi, Masahiro; Saitoh, Satoshi; Suzuki, Fumitaka; Akuta, Norio; Someya, Takashi; Ikeda, Kenji; Kumada, Hiromitsu // Journal of Gastroenterology;2003, Vol. 38 Issue 5, p493 

    Of a total of 2342 patients with type-C chronic hepatitis treated with interferon (IFN) at this hospital, 3 patients developed jaundice during the course of IFN therapy, but all 3 of them exhibited negative conversion of hepatitis C virus (HCV)-RNA following readministration of IFN. All 3...

  • Hepatitis C Linked to Fat Enzyme.  // BioWorld Today;10/11/2010, Vol. 21 Issue 196, Special section p1 

    The article reports on a study which discovered the role of an enzyme associated with the storage of fat in the liver in the infectious activity of the hepatitis C virus (HCV), conducted by scientists at the Gladstone Institute of Virology and Immunology.

  • Spontaneous remission of chronic hepatitis C in children. Fujisawa, T.; Komatsu, H.; Inui, A.; Miyagawa, Y.; Onoue, M.; Sekine, I.; Yokota, S.; Hanada, R.; Yamamoto, K.; Inui, M. // European Journal of Pediatrics;1997, Vol. 156 Issue 10, p773 

    The clinical course of 48 children with chronic hepatitis C (33 boys, 15 girls; mean age: 12.2 years) was monitored for more than 3 years to clarify its natural course. All patients were positive for the second-generation antibody to hepatitis C virus (anti-HCV) and for serum hepatitis C virus...

  • Persistence Rate and Progression of Vertically Acquired Hepatitis C Infection. Tovo, Pier-Angelo; Pembrey, Lucy Jane; Newell, Marie-Louise // Journal of Infectious Diseases;2/1/2000, Vol. 181 Issue 2, p419 

    Describes the natural history of perinatal hepatitis C virus (HCV) infection. Use of interferon in the standard treatment for adults with chronic hepatitis C; Mother-to-child transmission of HCV; Establishment of the European Pediatric Hepatitis C Virus Infection Network to elucidate issues...

  • Living with hepatitis C, multiple issues to face. Coudray, Mathilde; De Carvalho, Elisabete // Retrovirology;2012 Supplement 1, Vol. 9 Issue Supplment 1, p1 

    An abstract of the article "Living with hepatitis C, multiple issues to face," by Mathilde Coudray and Elisabete de Carvalho is presented.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics